AG1478 化学特性,用途語,生産方法
使用
Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.
一般的な説明
Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC
50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (
neu/erb-B2) receptor (IC
50 >100 μM), the platelet-derived growth factor (PDGF) receptor (IC
50 >100 μM), and p210
Bcr-Abl (IC
50 >50 μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
Biochem/physiol Actions
Primary TargetEpidermal growth factor receptor kinase
AG1478 上流と下流の製品情報
原材料
準備製品