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ビノレルビン二酒石酸塩

ビノレルビン二酒石酸塩 化学構造式
125317-39-7
CAS番号.
125317-39-7
化学名:
ビノレルビン二酒石酸塩
别名:
ビノレルビン二酒石酸塩;二酒石酸ビノルエルビン;酒石酸ビノレルビン;ビノレルビン 二酒石酸塩 水和物;ビノレルビン酒石酸塩;ビノレルビン酒石酸塩 (JAN)
英語化学名:
Vinorelbine tartrate
英語别名:
NVB;KW-2307;Eunades;NAVELBINE;Pacilitaxel;VINORELBINE(RG);lbine Ditartrate;butanedioate(1:2);NAVELBINE TARTRATE;Vinorelbin artrate
CBNumber:
CB8761554
化学式:
C53H66N4O20
分子量:
1079.11
MOL File:
125317-39-7.mol

ビノレルビン二酒石酸塩 物理性質

融点 :
181-183°C
貯蔵温度 :
2-8°C
溶解性:
H2O: 10 mg/mL
外見 :
powder
色:
off-white
InChIKey:
PMDHUNWDGZSEMN-WTUOTUPFSA-N
CAS データベース:
125317-39-7(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  43
Sフレーズ  26-36
RIDADR  UN 1544PSN1 6.1 / PGII
WGK Germany  3
HSコード  29339900
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H300 飲み込むと生命に危険 急性毒性、経口 1, 2 危険 P264, P270, P301+P310, P321, P330,P405, P501
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
注意書き
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

ビノレルビン二酒石酸塩 価格 もっと(14)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01BVI1957-5
Vinorelbine Tartrate
125317-39-7 5mg ¥20800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01BVI1957-25
Vinorelbine Tartrate
125317-39-7 25mg ¥71500 2018-12-26 購入
Sigma-Aldrich Japan 1714506 United States Pharmacopeia (USP) Reference Standard
Vinorelbine tartrate United States Pharmacopeia (USP) Reference Standard
125317-39-7 200mg ¥676500 2018-12-25 購入
富士フイルム和光純薬株式会社(wako) W01TRCV315000 ビノレルビン二酒石酸塩
Vinorelbine Ditartrate
125317-39-7 25mg ¥43800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01W0122-0164 ビノレルビン二酒石酸塩 98.0+% (HPLC)
Vinorelbine Ditartrate 98.0+% (HPLC)
125317-39-7 50mg ¥48000 2018-12-26 購入

ビノレルビン二酒石酸塩 化学特性,用途語,生産方法

外観

白色〜わずかにうすい褐色, 結晶性粉末〜粉末

溶解性

水、メタノール、エタノール(99.5)に極めて溶けやすく、アセトンに溶けやすく、ヘキサンにほとんど溶けない。

用途

がん研究用試薬

用途

有糸分裂時に微小管の構成タ ンパク質チューブリンに選択的に作用するこ とにより、重合阻害作用を示します。

効能

抗悪性腫瘍薬, 微小管重合阻害薬

商品名

ナベルビン (協和発酵キリン)

使用上の注意

不活性ガス封入

化学的特性

Pale Yellow Powder

使用

An antineoplastic

定義

ChEBI: The L-(+)-tartrate salt of vinorelbine.

brand name

Navelbine (Pierre).

一般的な説明

Vinorelbine ditartrate is available in 1- and 5-mL vials at aconcentration of 10 mg/mL for IV use. It is FDA approvedfor the treatment of NSCLC. The agent has also been usedin treating metastatic breast cancer, cervical cancer, uterinecancer, and lung cancer especially in older patients or thosewith physical difficulties. Vinorelbine is the most lipophilicof the vinca alkaloids because of modifications of thecatharanthine ring system and dehydration of the piperidinering. This allows the agent to be quickly taken up into cellsincluding lung tissue where concentrations are 300-foldhigher than plasma concentrations. This is 3 to 13 timeshigher than the lung concentrations seen with vincristine.The agent is highly protein bound (80%–91%) and metabolizedby CYP3A. The major metabolite seen is the 4-Odesacetylderivative, which is equally active with the parentbut only formed in small quantities. The agent is eliminatedprimarily (33%–88%) in the bile with some appearing inthe urine (16%–30%). The elimination half-life is 27 to43 hours. The toxicities seen for vinorelbine includemyelosuppression, which is dose limiting but ceases upondiscontinuation of drug. This is most commonly seen as aneutropenia, and patient’s neutrophil count should be monitoredprior to and during therapy to decrease the chanceof infection. Additional toxicities include nausea/vomiting,elevation of liver function tests, alopecia, generalized fatigue,and inappropriate secretion of antidiuretic hormone.Neurotoxicity is seen with vinorelbine but occurs to a lesserdegree compared with other vinca alkaloids because of itsdecreased affinity for axonal microtubules.

生物活性

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC 50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC 50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

ビノレルビン二酒石酸塩 上流と下流の製品情報

原材料

準備製品


ビノレルビン二酒石酸塩 生産企業

Global( 322)Suppliers
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Hainan Xiyuan Chemical Technology Co., Ltd.
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15008981366@163.com CHINA 9 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Nanjing Finetech Chemical Co., Ltd.
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025-85710122 sales@fine-chemtech.com CHINA 890 55
Hebei Chisure Biotechnology Co., Ltd.
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Shanghai Zheyan Biotech Co., Ltd.
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career henan chemical co
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Biochempartner
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Shenzhen Nexconn Pharmatechs Ltd
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admin@nexconn.com CHINA 3035 58

125317-39-7(ビノレルビン二酒石酸塩)キーワード:


  • 125317-39-7
  • KW-2307
  • 5μ-Noranhydrovinoblastine tartrate, KW-2307, Navelbine tartrate, NVB, 3μ,4μ-Didehydro-4μ-deoxy-Cμ-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt]
  • Vinorelbine hydrate ditartrate salt
  • Vinorelbine Bitartarate
  • (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylicacidmethylester
  • Vinorelbine ditartrate salt hydrate,3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartr
  • Vinorelbine Tartrate (200 mg)
  • Methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(1R,12S,14R)-16-ethyl-12-(Methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^{3,11}.0^{4,9}]octadeca-3(11),4(9),5,7,15-pentaen-12-yl]-10-hydroxy-5-Methoxy-8-Methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0
  • Vinorelbine ditartate
  • lbine Ditartrate
  • Vinoreline Tartrate
  • Vinorelbine Tartrate USP/EP
  • NVB
  • NAVELBINE
  • NAVELBINE TARTRATE
  • VINORELBINE BITARTRATE
  • VINORELBINE DITARTARIC ACID
  • VINORELBINE DITARTRATE
  • VINORELBINE DITARTRATE SALT
  • VINORELBINE TARTRATE
  • butanedioate(1:2)
  • c’-norvincaleukoblastine,3’,4’-didehydro-4’-dioxy-,(r-(r*,r*))-2,3-dihydroxy
  • 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate
  • 5'-NORANHYDROVINOBLASTINE TARTRATE
  • 3',4'-DIDEHYDRO-4'-DEOXY-C'-NORVINCALEUKOBLASTINE [R-(R*,R*)-2-3-DIHYDROXYBUTANEDIOATE (1:2) SALT]
  • Pacilitaxel
  • VINORELBINEDITARTRATE SALT HYDRATE
  • VINORELBINE TARTRATE USP STANDARD
  • VINORELBINE TARTRATE, NAVELBINE
  • VINORELBINE RELATED COMPOUND A4-O-DEACETYLVINORELBINE TARTRATE USP STANDARD
  • ビノレルビン二酒石酸塩
  • 二酒石酸ビノルエルビン
  • 酒石酸ビノレルビン
  • ビノレルビン 二酒石酸塩 水和物
  • ビノレルビン酒石酸塩
  • ビノレルビン酒石酸塩 (JAN)
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