ヒドロキシメタンスルフィン酸ナトリウム二水和物 化学特性,用途語,生産方法
外観
白色, 粉末又は塊
定義
本品は、次の化学式で表される有機化合物である。
溶解性
水に易溶。水に溶ける。
用途
還元剤、捺染剤。
化粧品の成分用途
還元剤
効能
保存剤
化学的特性
white solid; used as stripping and discharge agent for textiles [HAW93]
使用
Pharmaceutic aid (preservative).
調製方法
Sodium formaldehyde sulfoxylate is manufactured from sodium
dithionate and formaldehyde in water.
応用例（製薬）
Sodium formaldehyde sulfoxylate is a water-soluble antioxidant
and is generally used as the dihydrate. It is used in the formulation
of injection products at a level of up to 0.1% w/v in the final
preparation administered to the patient.
安全性
The toxicological properties of sodium formaldehyde sulfoxylate
have not been fully investigated. However, it is used in the
formulation of injection products at a level to 0.1% w/v in the
final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by
ingestion, and when heated to decomposition it emits toxic fumes
of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg
貯蔵
Store in well-closed, light-resistant containers at controlled room
temperature (15–30℃).
純化方法
It crystallises from H2O as the dihydrate and decomposes at higher temperatures. Store it in a closed container in a cool place. It is insoluble in EtOH and Et2O and is a good reducing agent. [X-ray structure: Tuter J Chem Soc 3064 1955.] Note that this compound {HOCH2SO2Na} should not be confused with formaldehyde sodium bisulfite adduct {HOCH2SO3Na} from which it is prepared by reduction with Zn. [Beilstein 1 IV 3052.]
不和合性
Sodium formaldehyde sulfoxylate is incompatible with strong
oxidizing agents; it is decomposed by dilute acid.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (parenteral
products up to 0.1% via the IM, IV, and SC routes). Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
ヒドロキシメタンスルフィン酸ナトリウム二水和物 上流と下流の製品情報
原材料
準備製品
トリフルオロアセトアルデヒドアセタール
1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-ヘプタデカフルオロオクタン