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N,N-ジメチルアセトアミド

N,N-ジメチルアセトアミド 化学構造式
127-19-5
CAS番号.
127-19-5
化学名:
N,N-ジメチルアセトアミド
别名:
N,N-ジメチルアセトアミド;ジメチルアセトアミド;酢酸ジメチルアミド;N-メチル-N-メチルアセトアミド;N-アセチルジメチルアミン;アセトジメチルアミド;DNAC;N,N-ジメチルアセトアミド(脱水);N,Nジメチルアセトアミド;N,N-ジメチルアセトアミド(DMA);N,N‐ジメチルアセトアミド;N,N‐ジメチルアセトアミド(脱水);N,N-ジメチルアセトアミド PURISS. P.A.,≥99.5% (GC);N,N-ジメチルアセトアミド REAGENTPLUS,99%;N,N-ジメチルアセトアミド クロマソルブ GC-HEADSPACE TESTED,≥99.9%;N,N-ジメチルアセトアミド クロマソルブ PLUS,FOR HPLC,≥99.9%;N,N-ジメチルアセトアミド(DMAC);N.N-ジメチルアセトアミド;N,N-ジメチルアセトアミド (超脱水);N,N-ジメチルアセトアミド 溶液
英語化学名:
N,N-Dimethylacetamide
英語别名:
DMAC;U-5954;SK 7176;nsc3138;NSC 3138;OmniPure?;CBC 510337;CH3CON(CH3)2;Acetic acid-di;dimethylacetamid
CBNumber:
CB8853004
化学式:
C4H9NO
分子量:
87.12
MOL File:
127-19-5.mol

N,N-ジメチルアセトアミド 物理性質

融点 :
-20 °C
沸点 :
164.5-166 °C(lit.)
比重(密度) :
0.937 g/mL at 25 °C(lit.)
蒸気密度:
3.89 (vs air)
蒸気圧:
40 mm Hg ( 19.4 °C)
屈折率 :
n20/D 1.439(lit.)
闪点 :
158 °F
貯蔵温度 :
0-6°C
溶解性:
>1000g/l soluble
外見 :
Liquid
色:
Colorless to yellowish
PH:
4 (200g/l, H2O, 20℃)
Relative polarity:
6.3
爆発限界(explosive limit):
1.7-11.5%(V)
水溶解度 :
miscible
極大吸収波長 (λmax):
λ: 270 nm Amax: 1.00
λ: 280 nm Amax: 0.30
λ: 290 nm Amax: 0.15
λ: 310 nm Amax: 0.05
λ: 320 nm Amax: 0.03
λ: 360-400 nm Amax: 0.01
Merck :
14,3227
BRN :
1737614
安定性::
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey:
FXHOOIRPVKKKFG-UHFFFAOYSA-N
CAS データベース:
127-19-5(CAS DataBase Reference)
NISTの化学物質情報:
Acetamide, N,N-dimethyl-(127-19-5)
EPAの化学物質情報:
Acetamide, N,N-dimethyl-(127-19-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,Xn,T
Rフレーズ  11-20/22-61-20/21-36
Sフレーズ  16-24-53-45-36-28-26
RIDADR  UN 1279 3/PG 2
WGK Germany  3
RTECS 番号 TX9625000
3-10
自然発火温度 914 °F
TSCA  Yes
HSコード  29241900
有毒物質データの 127-19-5(Hazardous Substances Data)
毒性 LD50 orally in rats: 5.4 ml/kg (Bartsch)
消防法 危険物第4類第二石油類(水溶性)
化審法 (2)-723
安衛法 57,57-2
PRTR法 第一種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H227 引火性液体 引火性液体 4 警告 P210, P280, P370+P378, P403+P235,P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H320 眼刺激 眼に対する重篤な損傷性/眼刺激 性 2B 警告 P264, P305+P351+P338,P337+P313
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H336 眠気やめまいのおそれ 特定標的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H360 生殖能または胎児への悪影響のおそれ 生殖毒性 1A, 1B 危険
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P271 屋外または換気の良い場所でのみ使用すること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

N,N-ジメチルアセトアミド 価格 もっと(68)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MPB02150928 N,N-ジメチルアセトアミド
N,N-Dimethylacetamide
127-19-5 250mL ¥7500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01MPB02150928 N,N-ジメチルアセトアミド
N,N-Dimethylacetamide
127-19-5 500mL ¥12400 2018-12-26 購入
東京化成工業 D0641 N,N-ジメチルアセトアミド >99.0%(GC)
N,N-Dimethylacetamide >99.0%(GC)
127-19-5 500mL ¥2900 2018-12-04 購入
東京化成工業 D0641 N,N-ジメチルアセトアミド >99.0%(GC)
N,N-Dimethylacetamide >99.0%(GC)
127-19-5 25mL ¥1600 2018-12-04 購入
関東化学株式会社(KANTO) 10306-01 N,N‐ジメチルアセトアミド >98.5%(GC)
N,N‐Dimethylacetamide >98.5%(GC)
127-19-5 500mL ¥2100 2018-12-13 購入

N,N-ジメチルアセトアミド MSDS


Acetdimethylamide

N,N-ジメチルアセトアミド 化学特性,用途語,生産方法

外観

無色〜ほとんど無色, 澄明の液体

溶解性

水、エタノール及びアセトンに極めて溶けやすい。

用途

繊維製造段階に溶剤として使用

用途

溶剤、樹脂剥離剤、医薬原料

用途

反応溶媒、精製溶剤、樹脂溶剤

使用上の注意

不活性ガス封入

化学的特性

colourless liquid with a faint ammonia odour

化学的特性

Dimethylacetamide occurs as a clear, colorless, slightly hygroscopic liquid. It has a weak ammonia-like or fish-like odor.

使用

Solvent for many organic reactions and in industrial applications.

定義

ChEBI: A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.

調製方法

Dimethylacetamide has been produced by the reaction of acetic acid with dimethylamine (Siegle, 1980).

調製方法

Dimethylacetamide is manufactured from acetic acid and dimethylamine in a closed system.

一般的な説明

A clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145°F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin.

空気と水の反応

Water soluble.

反応プロフィール

N,N-Dimethylacetamide is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. N,N-Dimethylacetamide can react violently in the presence of iron. Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.

健康ハザード

Liquid causes mild irritation of eyes and skin. Ingestion causes depression, lethargy, confusion and disorientation, visual and auditory hallucinations, perceptual distortions, delusions, emotional detachment, and affective blunting.

健康ハザード

A study of 41 workers who had been exposed to dimethylacetamide from 2 to 10 years revealed the occurrence of disorders reflecting liver damage (Corsi, 1971). Retention of bromosulfophthalein was increased in 9 of 10 workers who had been exposed to dimethylacetamide for 7 to 10 years, and in 10 of 20 workers who had been exposed to dimethylacetamide for 2 to 7 years. Other parameters of hepatic function which were altered in the exposed individuals include proteinemia, cholesterolemia, activities of hepatic transaminases and alkaline phosphatase in serum, and bilirubinemia. Hepatomegaly was diagnosed in 14 workers.
In a clinical trial, dimethylacetamide was administered to patients with advanced malignancies and caused abnormal mental states (Weiss et al 1962a, b). This effect was observed at a dose of 400 mg/kg given daily for 3 or more days.
The symptoms were not seen at 300 mg/kg or lower. The second or third dose caused depression, lethargy, occasional confusion or disorientation. The fourth or fifth dose produced striking hallucinations, perceptual distortions and delusions in all nine patients. All patients reverted to normal several days after discontinuation of treatment with dimethylacetamide.

火災危険

N,N-Dimethylacetamide is combustible.

応用例(製薬)

Dimethylacetamide is used as a solvent in oral and injectable pharmaceutical formulations. It has been used as a cosolvent to solubilize poorly soluble drugs. The use of dimethylacetamide has also been investigated as a vehicle for the parenteral delivery of relatively small peptides.
The use of solvents such as dimethylacetamide has been shown to influence the size and rate of release of norfloxacin from nanoparticles.
Dimethylacetamide has also been used in topical formulations and has been evaluated as a permeation enhancer for transdermal drug delivery.

工業用途

Dimethylacetamide is a powerful industrial solvent, the uses of which are very similar to those of dimethylformamide (Siegle, 1980). Its strong solvent action renders it particularly useful in the manufacture of films and fibers and as a solvent for polyacrylonitrile, polyvinyl chloride, polyamides, cellulose derivatives and polystyrenes and in coatings and adhesive formulations. Dimethylacetamide dissolves many inorganic salts.

安全性プロファイル

Moderately toxic by skin contact, inhalation, intravenous, and intraperitoneal routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. A skin and eye irritant. Less toxic than dimethylformamide. Mutation data reported. Combustible when exposed to heat and flame. A moderate explosion hazard. Violent reaction with halogenated compounds (e.g., carbon tetrachloride, hexachlorocyclohexane) when heated above 9OOC. Iron powder catalyzes the reaction so that it initiates at 71OC. When heated to decomposition it emits toxic fumes of NOx

安全性

Dimethylacetamide is used in pharmaceutical preparations as a solvent in parenteral formulations and is generally regarded as a nontoxic material when used as an excipient. Animal toxicity studies indicate that dimethylacetamide is readily absorbed into the bloodstream following inhalation or topical application. Repeated exposure to dimethylacetamide may be harmful and can result in liver damage. High intravenous doses (>400mg/kg/day for 3 days) may be hallucinogenic.
LD50 (rabbit, SC): 9.6g/kg(11) LD50 (rat, IP): 2.75g/kg LD50 (rat, IV): 2.64g/kg LD50 (rat, oral): 4.93g/kg LD50 (mouse, inhalation): 7.2g/kg LD50 (mouse, IP): 2.8g/kg

代謝

Gas Chromatographie analysis of the urine of rats which had received dimethylacetamide by the subcutaneous route indicated the presence of N-methyl-acetamide and acetamide (Barnes and Ranta, 1972). Both metabolites were also found by the same authors in incubation mixtures of dimethylacetamide with rat liver homogenate. N-Methylacetamide was detected in the urine of human volunteers who had inhaled dimethylacetamide or absorbed dimethylacetamide vapor through the skin (Maxfield et al 1975). Measurement of the amount of the metabolite N-methylacetamide excreted by individuals exposed to dimethylacetamide vapors with or without face masks which allowed the inhalation of air free of dimethylacetamide indicated that more dimethylacetamide was absorbed through the lungs than through the skin. Interestingly, in this study, only 2-10% of the amount of dimethylacetamide inhaled was recovered in the urine in the form of N-methylacetamide. It has been suggested that the major urinary metabolite of the analogous dimethylformamide is N-(hydroxymethyl)-N-methylformamide and not N-methylformamide, since the carbinolamide decomposes on the gas chroma-tography column (to N-methylformamide) but is relatively stable in aqueous solution (Kestell et al 1986). In analogy, it would be logical to assume that the N-methylacetamide found in the urine after exposure to dimethylacetamide really arose from chemical breakdown of N-(hydroxymethyl)-N-methylacetamide during the analytical process. This contention, however, remains to be proven.

貯蔵

Dimethylacetamide should be stored in an airtight container, protected from light, in a cool, dry place. Dimethylacetamide has an almost unlimited shelf-life when kept in closed containers and under nitrogen. It is combustible.

純化方法

Shake the amide with BaO for several days, reflux it with BaO for 1hour, then fractionally distil it under reduced pressure. Store it over molecular sieves. [Beilstein 4 IV 180.]

不和合性

Dimethylacetamide is incompatible with carbon tetrachloride, oxidizing agents, halogenated compounds, and iron. It attacks plastic and rubber. Contact with strong oxidizers may cause fire.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (IM injections, IV injections and infusions). Included in parenteral medicines licensed in the UK.

N,N-ジメチルアセトアミド 上流と下流の製品情報

原材料

準備製品


N,N-ジメチルアセトアミド 生産企業

Global( 382)Suppliers
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86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1750 55
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127-19-5(N,N-ジメチルアセトアミド)キーワード:


  • 127-19-5
  • dimethylacetoneamide
  • Dimethylamid kyseliny octove
  • Dimethylamide acetate
  • dimethylamideacetate
  • dimethylamidkyselinyoctove
  • n,n-dimethyl-acetamid
  • n,n-dimethylacetamidesolution(40%orless)
  • N,N-Dimethylethanamide
  • NSC 3138
  • nsc3138
  • SK 7176
  • N N-DIMETHYLACETAMIDE DIST. 1 L
  • N,N-DIMETHYLACETAMIDE, ABS., O. MOLEC.-S IEVE (H2O <0.01%)
  • N N-DIMETHYLACETAMIDE ALDRASORB 99.8%
  • N,N-DIMETHYLACETAMIDE 'B&J BRAND'
  • N,N-DIMETHYLACETAMIDE, 99+%, SPECTROPHOT O-METRIC GRADE
  • N,N-DIMETHYLACETAMIDE, REAGENTPLUS, >=99%
  • N,N-DIMETHYLACETAMIDE, STANDARD FOR GC
  • N,N-DIMETHYLACETAMIDE, 99.9+%, HPLC GRAD E
  • N,N-DIMETHYLACETAMIDE GC STANDARD
  • N,N-DimethylacetamideC4H9NO>99%
  • N,N-DimethylacetamideCertified
  • DimethylAcetamideGr
  • N,N-Dimethylacetamide, extra pure, 99.5%
  • N,N-Dimethylacetamide, extra pure, 99+%
  • N,N-Dimethylacetamide, for analysis
  • N,N-Dimethylacetamide, for spectroscopy, 99+%
  • N,N-Dimethylacetamide, pure, 99%
  • N,N-Dimethylacetamide, water <100ppm, extra dry over mol. sieve
  • N,N-DIMETHYLACETAMIDE DISTILLED IN QUARTZ SOLVENT
  • N,N-ジメチルアセトアミド
  • ジメチルアセトアミド
  • 酢酸ジメチルアミド
  • N-メチル-N-メチルアセトアミド
  • N-アセチルジメチルアミン
  • アセトジメチルアミド
  • DNAC
  • N,N-ジメチルアセトアミド(脱水)
  • N,Nジメチルアセトアミド
  • N,N-ジメチルアセトアミド(DMA)
  • N,N‐ジメチルアセトアミド
  • N,N‐ジメチルアセトアミド(脱水)
  • N,N-ジメチルアセトアミド PURISS. P.A.,≥99.5% (GC)
  • N,N-ジメチルアセトアミド REAGENTPLUS,99%
  • N,N-ジメチルアセトアミド クロマソルブ GC-HEADSPACE TESTED,≥99.9%
  • N,N-ジメチルアセトアミド クロマソルブ PLUS,FOR HPLC,≥99.9%
  • N,N-ジメチルアセトアミド(DMAC)
  • N.N-ジメチルアセトアミド
  • N,N-ジメチルアセトアミド (超脱水)
  • N,N-ジメチルアセトアミド 溶液
  • N,N- ジメチルアセトアミド
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