PMPA(NAALADaseinhibitor)
PMPA(NAALADaseinhibitor) 物理性質
- 沸点 :
- 538.8±60.0 °C(Predicted)
- 比重(密度) :
- 1.658±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- room temp
- 溶解性:
- Soluble to 100 mM in sterile
- 酸解離定数(Pka):
- 2.06±0.10(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
- 水溶解度 :
- Soluble to 100 mM in water
PMPA(NAALADaseinhibitor) 価格
もっと(4)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC1380 |
PMPA (NAALADase inhibitor) |
173039-10-6 |
10mg |
￥57000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC1380 |
PMPA (NAALADase inhibitor) |
173039-10-6 |
50mg |
￥235000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1612 |
≥98% (HPLC)
2-PMPA ≥98% (HPLC) |
173039-10-6 |
5mg |
￥24600 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1612 |
≥98% (HPLC)
2-PMPA ≥98% (HPLC) |
173039-10-6 |
25mg |
￥78800 |
2024-03-01 |
購入 |
PMPA(NAALADaseinhibitor) 化学特性,用途語,生産方法
使用
2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.
生物活性
Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
Biochem/physiol Actions
2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).
PMPA(NAALADaseinhibitor) 上流と下流の製品情報
原材料
準備製品
PMPA(NAALADaseinhibitor) 生産企業
Global( 72)Suppliers
173039-10-6()キーワード:
- 173039-10-6
- PMPA(NAALADaseinhibitor)
- 2-(Phosphonomethyl)pentane-1,5-dioicacid
- 2-PMPA
- CS-2454
- 2-PMPA(NAALADaseinhibitor)
- NAALADASEINHIBITOR
- Pentanedioic acid, 2-(phosphonomethyl)-
- 2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA)
- inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA