E 3330
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- CAS番号.
- 136164-66-4
- 化学名:
- 别名:
- 英語名:
- E 3330
- 英語别名:
- E 3330;CS-1756;APX3330;APX 3330;E 3330;E-3330;E3330 (APX-3330);(2E)-3-(5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl))-2-nonyl-2-propenoic acid;(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid;Undecanoic acid, 2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-, (2E)-;(2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid E3330
- CBNumber:
- CB91355838
- 化学式:
- C21H30O6
- 分子量:
- 378.46
- MOL File:
- 136164-66-4.mol
- MSDS File:
- SDS
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E 3330 物理性質
- 融点 :
- 56-57 °C
- 沸点 :
- 542.2±50.0 °C(Predicted)
- 比重(密度) :
- 1.13±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：>20mg/mL
- 外見 :
- 粉
- 酸解離定数(Pka):
- 4.29±0.19(Predicted)
- 色:
- 赤からオレンジ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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Sigma-Aldrich Japan
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E8534 |
≥98% (HPLC)
E3330 ≥98% (HPLC) |
136164-66-4 |
5mg |
￥68300 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
|
E8534 |
≥98% (HPLC)
E3330 ≥98% (HPLC) |
136164-66-4 |
25mg |
￥165000 |
2024-03-01 |
購入 |
E 3330 化学特性,用途語,生産方法
使用
E 3330 is a potent and selective APE1 inhibitor used in the treatment for age related macular degeneration.
Biochem/physiol Actions
E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.
E 3330 上流と下流の製品情報
原材料
準備製品
E 3330 生産企業
Global( 57)Suppliers
- 136164-66-4
- (2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid E3330
- (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
- E 3330
- CS-1756
- E 3330;E-3330
- APX 3330
- APX3330
- Undecanoic acid, 2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-, (2E)-
- E3330 (APX-3330)
- pancreatic cancer,TNF-α,E3330,REF-1,NF-κB,HIFs,Inhibitor,HIF-PH,Nuclear factor-kappaB,APX-3330,APE1,APX 3330,NSCLC cells,neuroprotective,E 3330,APX3330,endonuclease,VEGFR,EPCs,AP-1,HUVECs,Nuclear factor-κB,Reactive Oxygen Species,DNA-binding,Activator Protein 1,DNA/RNA Synthesis,Hypoxia-inducible factors,orally,PANC1,HIF/HIF Prolyl-Hydroxylase,E-3330,anticancer,H1975,PCECs,inhibit,IL-8,Vascular endothelial growth factor receptor
- (2E)-3-(5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl))-2-nonyl-2-propenoic acid