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(S)-(+)-1,2-プロパンジオール

(S)-(+)-1,2-プロパンジオール 化学構造式
4254-15-3
CAS番号.
4254-15-3
化学名:
(S)-(+)-1,2-プロパンジオール
别名:
(S)-(+)-1,2-プロパンジオール;(S)-プロパン-1,2-ジオール;[S,(+)]-1,2-プロパンジオール;(2S)-プロパン-1,2-ジオール;(2S)-1,2-プロパンジオール;[S,(+)]-プロパン-1,2-ジオール;(+)-プロピレングリコール;(S)-1,2-プロパンジオール;(S)-(+)-プロパン-1,2-ジオール;(S)-プロピレングリコール;L-(+)-プロパンジオール;(S)-(+)-1,2-ジヒドロキシプロパン;(S)-(+)-プロピレングリコール;(S)‐プロピレングリコール;(S)-(+)-1,2-プロパンジオール, 99%
英語化学名:
(S)-(+)-1,2-Propanediol
英語别名:
S-1,2-Propancdiol;L-1,2-Propanediol;(S)-(+)-PROPANEDIOL;(S)-1,2-PROPANEDIOL;(2S)-1,2-Propanediol;(S)-Propane-1,2-diol;(2S)-propane-1,2-diol;1,2-Propanediol, (S)-;PROPYELENE GLYCOL pure;L-(+)-PROPYLENE GLYCOL
CBNumber:
CB9145670
化学式:
C3H8O2
分子量:
76.09
MOL File:
4254-15-3.mol

(S)-(+)-1,2-プロパンジオール 物理性質

融点 :
-59 °C
沸点 :
186-188 °C765 mm Hg(lit.)
比旋光度 :
16 º (c=neat)
比重(密度) :
1.036 g/mL at 20 °C(lit.)
屈折率 :
n20/D 1.432(lit.)
闪点 :
225 °F
貯蔵温度 :
2-8°C
溶解性:
Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
酸解離定数(Pka):
14.49±0.20(Predicted)
外見 :
Liquid
色:
Clear colorless
比重:
1.04
光学活性 (optical activity):
[α]20/D +16.5°, neat
爆発限界(explosive limit):
2.6-12.6%(V)
水溶解度 :
soluble
Sensitive :
Hygroscopic
Merck :
14,7855
BRN :
1718871
CAS データベース:
4254-15-3(CAS DataBase Reference)
NISTの化学物質情報:
(S)-(+)-1,2-Propanediol(4254-15-3)

安全性情報

主な危険性  Xn
Rフレーズ  36/37/38-22
Sフレーズ  24/25-36/37/39-26
WGK Germany  1
HSコード  29053200
消防法 危-4-3-III
化審法 (2)-234 優先評価化学物質

(S)-(+)-1,2-プロパンジオール 価格 もっと(20)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBOR-0816 (S)-(+)-1,2-プロパンジオール
(S)-(+)-1,2-Propanediol
4254-15-3 25g ¥7200 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBOR-0816 (S)-(+)-1,2-プロパンジオール
(S)-(+)-1,2-Propanediol
4254-15-3 5g ¥3600 2018-12-26 購入
東京化成工業 P1129 (S)-(+)-1,2-プロパンジオール >98.0%(GC)
(S)-(+)-1,2-Propanediol >98.0%(GC)
4254-15-3 5g ¥8700 2018-12-04 購入
東京化成工業 P1129 (S)-(+)-1,2-プロパンジオール >98.0%(GC)
(S)-(+)-1,2-Propanediol >98.0%(GC)
4254-15-3 25g ¥26900 2018-12-04 購入
関東化学株式会社(KANTO) 34255-35 (S)‐プロピレングリコール >97.0%(GC)
(S)‐Propylene glycol >97.0%(GC)
4254-15-3 25g ¥27000 2018-12-13 購入

(S)-(+)-1,2-プロパンジオール 化学特性,用途語,生産方法

化学的特性

Colorless to light yellow liqui

化学的特性

Propylene glycol is a clear, colorless, viscous, practically odorless liquid, with a sweet, slightly acrid taste resembling that of glycerin.

調製方法

Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.

応用例(製薬)

Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.

安全性

Propylene glycol is used in a wide variety of pharmaceutical formulations and is generally regarded as a relatively nontoxic material. It is also used extensively in foods and cosmetics. Probably as a consequence of its metabolism and excretion, propylene glycol is less toxic than other glycols. Propylene glycol is rapidly absorbed from the gastrointestinal tract; there is also evidence that it is absorbed topically when applied to damaged skin. It is extensively metabolized in the liver, mainly to lactic and pyruvic acids, and is also excreted unchanged in the urine.
In topical preparations, propylene glycol is regarded as minimally irritant,although it is more irritant than glycerin. There have been some reports of contact dermatitis associated with propylene glycol.Some local irritation is produced upon application to mucous membranes or when it is used under occlusive conditions.Parenteral administration may cause pain or irritation when propylene glycol is used in high concentration. Propylene glycol is estimated to be one-third as intoxicating as ethanol, with administration of large volumes being associated with adverse effects most commonly on the central nervous system, especially in neonates and children.Other adverse reactions reported, though generally isolated, include: ototoxicity;cardiovascular effects; seizures; and hyperosmolarity and lactic acidosis, both of which occur most frequently in patients with renal impairment. Adverse effects are more likely to occur following consumption of large quantities of propylene glycol or on adminstration to neonates, children under 4 years of age, pregnant women, and patients with hepatic or renal failure. Adverse events may also occur in patients treated with disulfiram or metronidazole.
On the basis of metabolic and toxicological data, the WHO has set an acceptable daily intake of propylene glycol at up to 25 mg/kg body-weight.Formulations containing 35% propylene glycol can cause hemolysis in humans.
In animal studies, there has been no evidence that propylene glycol is teratogenic or mutagenic. Rats can tolerate a repeated oral daily dose of up to 30 mL/kg body-weight in the diet over 6 months, while the dog is unaffected by a repeated oral daily dose of 2 g/kg in the diet for 2 years.
(mouse, IP): 9.72 g/kg
(mouse, IV): 6.63 g/kg
(mouse, oral): 22.0 g/kg
(mouse, SC): 17.34 g/kg
(rat, IM): 0.01 g/kg
(rat, IP): 6.66 g/kg
(rat, IV): 6.42 g/kg
(rat, oral): 0.02 g/kg
(rat, SC): 22.5 g/kg

貯蔵

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

不和合性

Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

(S)-(+)-1,2-プロパンジオール 上流と下流の製品情報

原材料

準備製品


(S)-(+)-1,2-プロパンジオール 生産企業

Global( 228)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21671 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 12231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8918 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58

4254-15-3((S)-(+)-1,2-プロパンジオール)キーワード:


  • 4254-15-3
  • (S)-(+)-1,2-Dihydroxypropane (S)-(+)-Propylene Glycol
  • (S)-(+)-1,2-Propanediol,97%
  • (S)-(+)-1,2-Propanediol,99%
  • 1,2-Propanediol, (S)-
  • (2S)-propane-1,2-diol
  • S-1,2-Propancdiol
  • (S)-(+)-1,2-PROPANEDIOL FOR SYNTHESIS
  • (S)-(+)-1,2-Propanediol 96%
  • PROPYELENE GLYCOL pure
  • PROPYLENE GLYCOL extrapure AR
  • (2S)-1,2-Propanediol
  • (S)-(+)-1,2-Propanediol,96%
  • (S)-(+)-1,2-Propanediol, 96% 5GR
  • L-1,2-Propanediol
  • (S)-(+)-propylene glycero
  • (S)-(+)-Propane-1,2-diol
  • (S)-Propane-1,2-diol
  • L-(+)-PROPYLENE GLYCOL
  • (S)-(+)-PROPANEDIOL
  • (S)-(+)-PROPYLENE GLYCEROL
  • (S)-(+)-PROPYLENE GLYCOL
  • (S)-(+)-1,2-DIHYDROXYPROPANE
  • (S)-(+)-1,2-PROPANEDIOL
  • (S)-1,2-PROPANEDIOL
  • 1,2-PROPANEDIOL, 1000MG, NEAT
  • ALUMINUM NITRATE NONAHYDRATE 98+% &
  • (S)-(+)-1,2-プロパンジオール
  • (S)-プロパン-1,2-ジオール
  • [S,(+)]-1,2-プロパンジオール
  • (2S)-プロパン-1,2-ジオール
  • (2S)-1,2-プロパンジオール
  • [S,(+)]-プロパン-1,2-ジオール
  • (+)-プロピレングリコール
  • (S)-1,2-プロパンジオール
  • (S)-(+)-プロパン-1,2-ジオール
  • (S)-プロピレングリコール
  • L-(+)-プロパンジオール
  • (S)-(+)-1,2-ジヒドロキシプロパン
  • (S)-(+)-プロピレングリコール
  • (S)‐プロピレングリコール
  • (S)-(+)-1,2-プロパンジオール, 99%
  • アルコール (光学活性)
  • 光学活性化合物
  • 有機合成化学
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