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バシトラシン標準品

バシトラシン標準品 化学構造式
1405-87-4
CAS番号.
1405-87-4
化学名:
バシトラシン標準品
别名:
バシ-ジェル;シロトラシン;ズトラシン;フォルトラシン;アイフィビン;バシトラシン;トピトラシン;ペニトラシン;ギネバチン;パレントラシン;バシトラシン標準品;バシトラシン (>80%);バシトラシン A
英語化学名:
Bacitracin
英語别名:
septa;ayfivin;Agfivin;baci-jel;usafcb-7;BACIDRIN;ALTRACIN;Zutracin;Baciguen;baciguent
CBNumber:
CB9165863
化学式:
C66H102N17O16S
分子量:
1421.68538
MOL File:
1405-87-4.mol

バシトラシン標準品 物理性質

融点 :
221-225°C
比重(密度) :
1.0166 (rough estimate)
屈折率 :
1.6700 (estimate)
貯蔵温度 :
2-8°C
溶解性:
H2O: 50 mg/mL, clear to very slightly hazy, deep yellow
外見 :
Powder
色:
white to faintly beige
水溶解度 :
soluble
Merck :
13,936
EPAの化学物質情報:
Bacitracin(1405-87-4)

安全性情報

主な危険性  Xn
Rフレーズ  20/21/22
Sフレーズ  22-24/25-45-36
WGK Germany  2
RTECS 番号 CP0175000
21
TSCA  Yes
HSコード  29419090
有毒物質データの 1405-87-4(Hazardous Substances Data)

バシトラシン標準品 価格 もっと(15)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCB106500 バシトラシン (>80%)
Bacitracin (>80%)
1405-87-4 10g ¥15000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCB106500 バシトラシン (>80%)
Bacitracin (>80%)
1405-87-4 100g ¥67500 2018-12-26 購入
関東化学株式会社(KANTO) 22610-1A バシトラシン
Bacitracin
1405-87-4 5g ¥11800 2018-12-13 購入
関東化学株式会社(KANTO) 22610-2A バシトラシン
Bacitracin
1405-87-4 25g ¥46700 2018-12-13 購入
Sigma-Aldrich Japan 11702 バシトラシン from Bacillus licheniformis, ≥60000?U/g (Potency)
Bacitracin from Bacillus licheniformis, ≥60000?U/g (Potency)
1405-87-4 25g ¥68900 2018-12-25 購入

バシトラシン標準品 MSDS


Bacitracin

バシトラシン標準品 化学特性,用途語,生産方法

外観

白色~うすい褐色, 粉末

溶解性

水に易溶、エタノールに可溶、エーテルにほとんど不溶。

用途

細胞同定用ディスク及び培地添加用。

用途

ペプチド系抗生物質です。細 菌の細胞壁ペプチドグリカン生合成系を阻害 することで、抗菌作用を示します。ほとん どはバシトラシン A ですが、バシトラシン A,B,C,D,E など少なくとも 9 種以上の混合物 です。

化学的特性

White to pale buff powder

化学的特性

Bacitracin is a white to light tan powder which is odorless or having a slight odor and very bitter taste.

使用

Polypeptide antibacterial.

使用

Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting depho sphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.

定義

A complex of cyclic peptide antibiotic of known chemical structure isolated from the Tracy-I strain of Bacillus subtilis.

brand name

Ziba (X Gen).

一般的な説明

The organism from which Johnson et al. produced bacitracinin 1945 is a strain of B. subtilis. The organism hadbeen isolated from debrided tissue from a compound fracturein 7-year-old Margaret Tracy, hence the name “bacitracin.”Bacitracin is now produced from the licheniformisgroup (B. subtilis). Like tyrothricin, the first useful antibioticobtained from bacterial cultures, bacitracin is a complex mixture of polypeptides. So far, at least 10 polypeptideshave been isolated by countercurrent distribution techniques:A, A1, B, C, D, E, F1, F2, F3, and G. The commercialproduct known as bacitracin is a mixture of principallyA, with smaller amounts of B, D, E, and F1–3.The official product is a white to pale buff powder that isodorless or nearly so.
The activity of bacitracin is measured in units per milligram.The potency per milligram is not less than40 units/mg except for material prepared for parenteral use,which has a potency of not less than 50 units/mg. It is a bactericidalantibiotic that is active against a wide variety ofGram-positive organisms, very few Gram-negative organisms,and some others. It is believed to exert its bactericidaleffect through inhibition of mucopeptide cell wall synthesis.Its action is enhanced by zinc. Although bacitracin hasfound its widest use in topical preparations for local infections,it is quite effective in several systemic and local infectionswhen administered parenterally. It is not absorbedfrom the GI tract; accordingly, oral administration is withouteffect, except for the treatment of amebic infectionswithin the alimentary canal.

危険性

Poison; moderately toxic; mutagen.

応用例(製薬)

A mixture of peptides produced by Bacillus licheniformis. Bacitracin A is the major constituent of commercial preparations. The more stable zinc salt is used in topical formulations. It has been widely used as a growth promoter in animals, but has been banned for that purpose in the European Union.
It is highly active against many Gram-positive bacteria and is mainly used as a component of topical preparations. Although strains of Staph. aureus are usually susceptible, they are rather less so than most other Gram-positive bacteria. Streptococcus pyogenes is so much more susceptible than other hemolytic streptococci that bacitracin susceptibility is used as a screening test for identification. Clostridium difficile and Actinomyces spp. are susceptible, but enterobacteria and Pseudomonas spp. are resistant. Entamoeba histolytica is inhibited by 0.6–10 mg/L.
Resistance is uncommon, but has been detected in Staph. aureus following topical treatment.
It is nephrotoxic and unsuitable for parenteral use. Systemic toxicity from application to skin or ulcerated areas is rare, but it may cause allergic reactions and occasional anaphylaxis has been described. It is found in many ointments and ophthalmic preparations, usually together with other components, including polymyxins, neomycin and corticosteroids.
Bacitracin is not absorbed by mouth but oral preparations have been used for suppression of gut flora, including C. difficile.

安全性プロファイル

A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported.

職業ばく露

Bacitracin is used as an ingredient in antibiotic ointments to treat or prevent topical or eye infections. Commercial Bacitracin is a mixture of at least 9 bacitracins. Also used as a feed and drinking water additive for animals; as a food additive for human consumption.

輸送方法

UN 3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials.

純化方法

Bacitracin has been purified by carrier displacement using n-heptanol, n-octanol and n-nonanol as carriers and 50% EtOH in 0.1 N HCl. The pure material gives one spot with RF ~0.5 on paper chromatography using AcOH:n-BuOH:H2O (4:1:5). [Porath Acta Chem Scand 6 1237 1952.] It has also been purified by ion-exchange chromatography. It is a white powder soluble in H2O and EtOH but insoluble in Et2O, CHCl3 and Me2CO. It is stable in acidic solution but unstable in base. It is a strong antibacterial. [Abraham & Bewton Biochem J 47 257 1950, Synthesis: Munekata et al. Bull Chem Soc Jpn 46 3187, 3835 1973, Beilstein 27 III/IV 5746.]

不和合性

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

廃棄物の処理

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

バシトラシン標準品 上流と下流の製品情報

原材料

準備製品


バシトラシン標準品 生産企業

Global( 197)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21668 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 488 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2997 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58

1405-87-4(バシトラシン標準品)キーワード:


  • 1405-87-4
  • ai3-50147-x
  • ak-tracin
  • ayfivin
  • baciguent
  • baci-jel
  • baciliquin
  • bacitekointment
  • bacitracine(french)
  • bacitracin-neomycin-polymyxinointment
  • bacitracinum(latin)
  • bactinetripleantibiotic
  • campho-pheniquetriplepluspainreliever
  • caswellno065
  • epapesticidechemicalcode006302
  • fortracin
  • mycitracinpluspainreliever
  • mycitracintripleantibioticfirstaidointmentmaximumstrength
  • parentracin
  • penitracin
  • septa
  • spectrocinplus
  • topitracin
  • topitrasin
  • usafcb-7
  • BACIDRIN
  • BACITRACIN
  • BACITRACIN A
  • BACITRACIN BACILLUS LICHENIFORMIS
  • GINEBATINE
  • ALTRACIN
  • バシ-ジェル
  • シロトラシン
  • ズトラシン
  • フォルトラシン
  • アイフィビン
  • バシトラシン
  • トピトラシン
  • ペニトラシン
  • ギネバチン
  • パレントラシン
  • バシトラシン標準品
  • バシトラシン (>80%)
  • バシトラシン A
  • ペプチド系抗生物質
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