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マラチオン

マラチオン 化学構造式
121-75-5
CAS番号.
121-75-5
化学名:
マラチオン
别名:
マラマール;シチオン;マラソン;ジチオりん酸O,O-ジメチルS-[1,2-ジ(エトキシカルボニル)エチル];マラトン;カルボホス;メルカプトチオン;ジチオりん酸O,O-ジメチル-S-1,2-ビス(エトキシカルボニル)エチル;マラスプレイ;2-[(ジメトキシホスフィノチオイル)チオ]ブタン二酸ジエチル;プリオデルム;マラチオン;マラチオン標準品;S-1,2-ビス(エトキシカルボニル)エチルO,O-ジメチルホスホロジチオアート;ジチオりん酸O,O-ジメチル-S-1,2-ビス(エトキシカルボニル)エチル (別名 マラソン又はマラチオン);ジエチル=2-[(ジメトキシホスホロチオイル)スルファニル]スクシナート;ジチオりん酸O,O-ジメチル-S-1,2-ビス (エトキシカルボニル) エチル;マラチオン 100ΜG/ML;マラチオン マラソン;マラソン標準物質
英語化学名:
Malathion
英語别名:
tak;4049;fog3;PALD;C-2k;CCNK;CPR4;CTK1;sf60;Etiol
CBNumber:
CB9182444
化学式:
C10H19O6PS2
分子量:
330.36
MOL File:
121-75-5.mol

マラチオン 物理性質

融点 :
2.85°C
沸点 :
156°C
比重(密度) :
1.2076
屈折率 :
nD25 1.4985
闪点 :
-18 °C
貯蔵温度 :
APPROX 4°C
溶解性:
Slightly soluble in water, miscible with acetone, with cyclohexane, with ethanol (96 per cent) and with vegetable oils.
外見 :
liquid
比重:
1.23 (25℃)
水溶解度 :
0.0145 g/100 mL
暴露限界値:
NIOSH REL: TWA 10 mg/m3, IDLH 250 mg/m3; OSHA PEL: TWA 15 mg/m3; ACGIH TLV: TWA 10 mg/m3.
安定性::
Stable. Incompatible with oxidizing agents, metals.
CAS データベース:
121-75-5(CAS DataBase Reference)
NISTの化学物質情報:
Malathion(121-75-5)
EPAの化学物質情報:
Butanedioic acid, [(dimethoxyphosphinothioyl) thio]-, diethyl ester(121-75-5)

安全性情報

主な危険性  Xn;N,N,Xn,F
Rフレーズ  22-50/53-67-65-38-11-43
Sフレーズ  2-24-60-61-62-46-37-16
RIDADR  UN 2783
RTECS 番号 WM8400000
国連危険物分類  6.1(b)
容器等級  III
HSコード  29309090
有毒物質データの 121-75-5(Hazardous Substances Data)
毒性 LD50 in female, male rats (mg/kg): 1000, 1375 orally (Gaines)
消防法 危-4-3-III
安衛法 57,57-2
PRTR法 1-197

マラチオン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

マラチオン 化学特性,用途語,生産方法

外観

無色〜黄褐色, 澄明の液体

溶解性

エタノール及びアセトンに極めて溶けやすく、水に極めて溶けにくい。

用途

マラソン試験用標準品。

用途

農薬(殺虫剤) (NITE CHRIP)

効能

殺シラミ薬, コリンエステラーゼ阻害薬

農薬用途

殺虫剤

説明

Malathion, a clear amber liquid, is sparingly soluble in water but soluble in a majority of organic solvents. The U.S. Environmental Protection Agency (U.S. EPA) grouped malathion under GUP, meaning general use pesticide. It is used as an insecticide as well as an acaricide for the control of pests. Malathion is used for the control of sucking insects and chewing insects on fruits and vegetables. Malathion is an effective insecticide for the control of several household pests such as houseflies, cockroaches, mosquitoes, aphids, animal ectoparasites, and human head and body lice. Malathion is also found in formulations with many other pesticides.

化学的特性

Malathion is a clear amber liquid. It is sparingly soluble in water, but soluble in a majority of organic solvents. The US EPA grouped malathion under GUP. It is used as an insecticide as well as an acaricide for the control of pests. Malathion is used for the control of sucking insects and chewing insects on fruits and vegetables, and is an effective insecticide for the control of several household pests, such as housefl ies, cockroaches, mosquitos, aphids, animal ectoparasites, and human head and body lice. It is also found in formulations with many other pesticides

化学的特性

Malathion is a deep-brown to yellow liquid with a garlic-like odor. Clear and colorless when pure; freezing/melting point5 3C;

使用

Used as an insecticide

使用

anticholinergic

使用

Malation is a pestanal and used primarily as an insecticide.

使用

Organophosphorus insecticide.

使用

Insecticide for control of sucking and chewing insects and spider mites on vegetables, fruits, ornamentals, field crops, greenhouses, gardens and forestry.

定義

ChEBI: A diester that is butanedioate substituted by a (dimethoxyphosphorothioyl)sulfanediyl group at position 2.

一般的な説明

Yellow to dark-brown liquid with a skunk-like odor. Sinks in water. Freezing point is 37°F.

一般的な説明

Malathion, 2-[(dimethoxyphosphinothioyl)thio]butanedioic acid diethyl ester, is a water-insolublephosphodithioate ester that has been used as an agriculturalinsecticide. Malathion is a poor inhibitor of cholinesterases.Its effectiveness as a safe insecticide is a result of the differentrates at which humans and insects metabolize the chemical.Microsomal oxidation, which causes desulfuration,occurs slowly to form the phosphothioate (malaoxon),which is 10,000 times more active than the phosphodithioate(malathion) as a cholinesterase inhibitor. Insects detoxifythe phosphothioate by a phosphatase, forming dimethylphosphorothioate, which is inactive as an inhibitor.Humans, however, can rapidly hydrolyze malathion by acarboxyesterase enzyme, yielding malathion acid, a stillpoorer inhibitor of AChE. Phosphatases and carboxyesterasesfurther metabolize malathion acid to dimethylphosphothioate.

空気と水の反応

Insoluble in water.

反応プロフィール

Malathion is a yellow to brown liquid that solidifies at 2.9° C, moderately toxic. Organic phosphate insecticide, acts as an inhibitor of cholinesterase. When heated to decomposition Malathion emits toxic fumes of oxides of sulfur and phosphorus [Lewis, 3rd ed., 1993, p. 789].

危険性

Absorbed by skin, cholinesterase inhibitor. Questionable carcinogen.

健康ハザード

Acute and prolonged period of exposures to high concentrations of malathion cause poisoning in animals and humans. The symptoms of poisoning include, but are not limited to, numbness, tingling sensations, incoordination, headache, dizziness, tremor, nausea, abdominal cramps, sweating, blurred vision, diffi culty breathing or respiratory depression, and slow heart beat. Very high doses may result in unconsciousness, incontinence, and convulsions, or fatality. Malathion did not indicate any kind of delayed neurotoxicity in experimental studies with hens. Reports have indicated that because of and accidental exposures through severe skin absorption, malathion caused poisoning and fatalities among workers associated with the malaria control operations in Pakistan. In certain cases, development of pulmonary fi brosis following the poisoning has also been observed. Reports have indicated that malathion is neither mutagenic nor teratogenic to animals and humans. In animals, malathion induced liver carcinogenicity at doses that were considered excessive. However, available information is not adequate to confi rm the carcinogenicity of malathion to animals and humans. The IARC has determined that malathion is unclassifi able as to its carcinogenicity to humans. The IARC observed that the available data do not provide evidence that malathion or its metabolite malaoxon is carcinogenic to experimental animals and there is no data on humans and classifi ed as Group 3 meaning, not classifi able as to carcinogenicity for humans.

健康ハザード

Cholinesterase inhibitor; toxic propertiessimilar to those of parathion; however,less toxic than parathion; moderately toxicby ingestion and possibly other routes ofexposure; toxic symptoms include excessivesalivation, lacrimation, blurred vision, con-striction of the pupils, nausea, vomiting,abdominal pain, and difficulty in breathing;also coma and death can result form largeintake; ingestion of 10–25 g could be fatalto adult humans; skin contact can produceallergic sensitization reaction; also absorbedthrough skin, causing systemic poisoning;experimental teratogen; LD50 data reportedin the literature show wide variation.
LD50 oral (rate): 300–2800 mg/kg
LD50 skin (mouse): 2000–3000 mg/kg
Benslama et al. (2004) have reported twounusual cases of malathion poisoning with arare-type of complication from “intermediatesyndrome” arising 2 to 4 days after the onsetof cholinergic effects. The symptoms wererespiratory paresis with difficulties of wean-ing from assisted respiratory, deficit of proximal limbs, neck flexors and cranial nerves.The authors attributed this syndrome to pro-longed inhibition of acetyl-cholinesterasesand not to any muscular fiber’s necrosis.

健康ハザード

Exposure to fumes from a fire or to liquid causes headache, blurred vision, constricted pupils of the eyes, weakness, nausea, cramps, diarrhea, and tightness in the chest. Muscles twitch and convulsions may follow. The symptoms may develop over a period of 8 hours.

农业用途

nsecticide: Not approved for use in EU countries. Malathion is a non-systemic, wide-spectrum organophosphate insecticide. It was one of the earliest organophosphate insecticides developed (introduced in 1950). Malathion is suited for the control of sucking and chewing insects on fruits, vegetables, citrus, cotton, corn, sorghum, ornamentals and stored products, and is also used to control mosquitoes, flies, household insects, farm and livestock parasites (ectoparasites), and head and body lice. Malathion may also be found in formulations with many other pesticides; the U.S. EPA lists 2,283 current and canceled labels of products containing malathion. Malathion is marketed as 99.6% technical grade liquid. Available formulations include wettable powders (25% and 50%), emulsifiable concentrates, dusts and aerosols.

製品名

AI3-17034®; AGRICHEM GREENFLY SPRAY®; ALCO® Malathion; ALL PURPOSE GARDEN INSECTICIDE®; AMERICAN CYANAMID 4,049®; ATRAPA 5E®; BAN-MITE®; CALMATHION®; CARBETOVUR®; CARBETOX®; CELTHION®; CHEMATHION®; CIMEXAN®; COMPOUND 4049®; CROMOCIDE®; CYTHION®; SPRAY CONCENTRATE®; CYTHION®; DETMOL MA®; DETMOL® 96%; DETMOL MALATHION®; DURAMITEX®; EMMATOS EXTRA®; EL 4049®; EMMATON®; EMMATOS®; ETIOL®; EVESHIELD CAPTAN/MALATHION®; EXATHIOS®; EXTERMATHION®; FYAFANON®; FISONS GREENFLY AND BLACKFLY KILLER®; FOG® 3; FORMAL®; FORTHION®; FOSFOTHION®; FOSFOTION®; FYFANON®; ETHIOLACAR®; GREEN DEVIL®; GREENFLY AEROSOL SPRAY®; HILTHION®; KARBOFOS®; KOPTHION ®; KYPFOS®; MALACIDE®; MALAFOR®; MALAGRAN®; MALAKILL®; MALAMAR®; MALASOL®; MALASPRAY®; MALATAF®; MALATHION 60®; MALATHION E50®; MALATOL®; MALTOX®; MOSCARDA®; ORTHO MALATHION®; PBI CROP SAVER®; PRENTOX®; PRIODERM®; PROKIL® Malathion; SADOFOS®; SADOPHOS®; SF® 60; SIPTOX I®; SUMITOX®; TAK®; TM-4049®; VETIOL®; ZITHIOL®

接触アレルゲン

This organophosphorus pesticide is used as an insecticide and an acaricide, particularly against head lice. Sensitization was reported in farmers.

安全性プロファイル

A human poison by ingestion and skin contact. Can penetrate intact skin. An experimental poison by ingesuon, inhalation, intraperitoneal, intravenous, intraarterial, and subcutaneous routes. Human systemic effects by ingestion: coma, blood pressure depression, and dfficulty in breathmg. Questionable carcinogen. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Has caused allerglc sensitization of the skin. An organic phosphate cholinesterase inhibitor. When heated to decomposition it emits toxic fumes of POx and SOx. See also PHOSPHATES and PARATHION.

職業ばく露

Malathion is marketed as 99.6% technical grade liquid. Available formulations include wetable powders (25% and 50%), emulsifiable concentrates, dusts, and aerosols. Malathion is used as a broad spectrum insecticide and acaricide in the control of certain insect pests on fruits, vegetables, and ornamental plants. It has been used in the control of houseflies, mosquitoes, lice; and on farm and livestock animals.

応急処置

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

環境運命予測

Biological. Walker (1976) reported that 97% of malathion added to both sterile and nonsterile estuarine water was degraded after incubation in the dark for 18 days. Complete degradation was obtained after 25 days. Malathion degraded fastest in nonsterile soils and decomposed faster in soils that were sterilized by gamma radiation than in soils that were sterilized by autoclaving. After 1 day of incubation, the amounts of malathion degradation that occurred in autoclaved, irradiated and nonsterile soils were 7, 90 and 97%, respectively (Getzin and Rosefield, 1968). Degradation of malathion in organic-rich soils was 3 to 6 times higher than in soils not containing organic matter. The half-life in an organic-rich soil was about 1 day (Gibson and Burns, 1977). Malathion was degraded by soil microcosms isolated from an agricultural area on Kauai, HI. Degradation half-lives in the laboratory and field experiments were 8.2 and 2 hours, respectively. Dimethyl phosphorodithioic acid and diethyl fumarate were identified as degradation products (Miles and Takashima, 1991). Mostafa et al. (1972) found the soil fungi Penicillium notatum, Aspergillus niger, Rhizoctonia solani, Rhizobium trifolii and Rhizobium leguminosarum converted malathion to the following metabolites: malathion diacid, dimethyl phosphorothioate, dimethyl phosphorodithioate, dimethyl phosphate, monomethyl phosphate and thiophosphates. Malathion also degraded in groundwater and seawater but at a slower rate (halflife 4.7 days). Microorganisms isolated from paper-mill effluents were responsible for the formation of malathion monocarboxylic acid (Singh and Seth, 1989).
Paris et al. (1975) isolated a heterogenous bacterial population that was capable of degrading low concentrations of malathion to b-malathion monoacid. About 1% of the original malathion concentration degraded to malathion dicarboxylic acid, O,O-dimethyl
Matsumura and Bousch (1966) isolated carboxylesterase(s) enzymes from the soil fungus Trichoderma viride and a bacterium Pseudomonas sp. obtained from Ohio soil samples that were capable of degrading malathion. Compounds identified included diethyl maleat
Soil. In soil, malathion was degraded by Arthrobacter sp. to malathion monoacid, malathion dicarboxylic acid, potassium dimethyl phosphorothioate and potassium dimethyl phosphorodithioate. After 10 days, degradation yields in sterile and nonsterile soils were 8, 5, 19% and 92, 94, 81%, respectively (Walker and Stojanovic, 1974). Chen et al. (1969) reported that the microbial conversion of malathion to malathion monoacid was a result of demethylation of the O-methyl group. Malathion was converted by unidentified microorganisms in soil to thiomalic acid, dimethyl thiophosphoric acid and diethylthiomaleate (Konrad et al., 1969).
The half-lives for malathion in soil incubated in the laboratory under aerobic conditions ranged from 0.2 to 2.1 days with an average of 0.8 days (Konrad et al., 1969; Walker and Stojanovic, 1973; Gibson and Burns, 1977).

輸送方法

UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

不和合性

Reacts violently with strong oxidizers, magnesium, alkaline pesticides. Attacks metals including iron, steel, tin plate; lead, copper; and some plastics, coatings, and rubbers

廃棄物の処理

Malathion is reported to be “hydrolyzed almost instantly” at pH 12; 50%; hydrolysis at pH 0 requires 12 hours. Alkaline hydrolysis under controlled conditions (0.5 n NaOH in ethanol) gives quantitative yields of (CH3O)2P(S)SNa, whereas hydrolysis in acidic media yields (CH3O)2P(S)OH. On prolonged contact with iron or iron-containing material, it is reported to break down and completely lose insecticidal activity. Incineration together with a flammable solvent in a furnace equipped with afterburner and scrubber is recommended. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

マラチオン 上流と下流の製品情報

原材料

準備製品


マラチオン 生産企業

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121-75-5(マラチオン)キーワード:


  • 121-75-5
  • S-[1,2-DICARBETHOXYETHYL]-O,O-DIMETHYL-DITHIOPHOSPHATE
  • O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate
  • O,O-DIETHYL S-[1,2-DI(ETHOXYCARBONYL)ETHYL]PHOSPHORODITHIOATE
  • PHOSPHOTHION(R)
  • ((dimethoxyphosphinothioyl)thio)-butanedioicacidiethylester
  • [(dimethoxyphosphinothioyl)thio]-butanedioicacidiethylester
  • 1,2-di(ethoxycarbonyl)ethylo,o-dimethylphosphorodithioate
  • 4049
  • 8059HC
  • AC 26691
  • ai3-17034
  • American Cyanamid 4,049
  • americancyanamid4,049
  • Butanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester
  • Butanedioicacid,[(dimethoxyphosphinothioyl)thio]-,diethylester
  • camathion
  • Carbethoxy malathion
  • carbethoxymalathion
  • carbetovur
  • Carbetox
  • caswellno535
  • Chemathion
  • cimexan
  • Compound 4049
  • compound4049
  • Cythion
  • detmolma
  • detmolma96%
  • Dicarboethoxyethyl O,O-dimethyl phosphorodithioate
  • dicarboethoxyethylo,o-dimethylphosphorodithioate
  • マラマール
  • シチオン
  • マラソン
  • ジチオりん酸O,O-ジメチルS-[1,2-ジ(エトキシカルボニル)エチル]
  • マラトン
  • カルボホス
  • メルカプトチオン
  • ジチオりん酸O,O-ジメチル-S-1,2-ビス(エトキシカルボニル)エチル
  • マラスプレイ
  • 2-[(ジメトキシホスフィノチオイル)チオ]ブタン二酸ジエチル
  • プリオデルム
  • マラチオン
  • マラチオン標準品
  • S-1,2-ビス(エトキシカルボニル)エチルO,O-ジメチルホスホロジチオアート
  • ジチオりん酸O,O-ジメチル-S-1,2-ビス(エトキシカルボニル)エチル (別名 マラソン又はマラチオン)
  • ジエチル=2-[(ジメトキシホスホロチオイル)スルファニル]スクシナート
  • ジチオりん酸O,O-ジメチル-S-1,2-ビス (エトキシカルボニル) エチル
  • マラチオン 100ΜG/ML
  • マラチオン マラソン
  • マラソン標準物質
  • マラソン標準品
  • マラチオン STANDARD
  • マラチオン Standard, 100 µg/mL in Methanol
  • マラチオン Standard, 1000 µg/mL in MeOH
  • マラチオン, 1000 µg/mL in Hexane
  • コリンエステラーゼ阻害剤
  • 防疫用殺虫剤
  • 有機リン系殺虫剤
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