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ピトレッシン

ピトレッシン 化学構造式
113-79-1
CAS番号.
113-79-1
化学名:
ピトレッシン
别名:
[Arg8]バソプレッシン;ピトレシン;アルギニンバソプレシン;アルギニンバソプレッシン;8-アルギニン-バソプレッシン;ピトレッシン;VASOPRESSIN (アルギニン型バソプレシン);[ARG8]-バソプレッシン;(ARG8)-バソプレッシン;[ARG8]-バソプレッシン 酢酸塩;[ARG8]-バソプレッシン 溶液;アルギプレッシン;タンニン酸バソプレシン
英語化学名:
Argipressine
英語别名:
AVP;argipressin;argipressine;β-Hypophamine;Arg-Vasopressin;BETA-HYPOPHAMINE;[ARG8]-VASOPRESSIN;VASOPRESSIN (ARG8);vasopressin tannate;(ARG-8) Vasapressin
CBNumber:
CB9205622
化学式:
C46H65N15O12S2
分子量:
1084.24
MOL File:
113-79-1.mol

ピトレッシン 物理性質

比重(密度) :
1.59±0.1 g/cm3(Predicted)
闪点 :
113℃
貯蔵温度 :
2-8°C
酸解離定数(Pka):
9.90±0.15(Predicted)
PH:
~3.5
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  20
Sフレーズ  36
WGK Germany  3
HSコード  2937190000
毒性 TDLo ivn-pig: 40 ng/kg JPETAB 293,852,2000
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

ピトレッシン 価格 もっと(14)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01BCS4012215
(Arg8)-Vasopressin, H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2, Trifluoroacetate, (Disulfide bond)
113-79-1 1mg ¥23000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01USP1711100 Vasopressin (アルギニン型バソプレシン)
Vasopressin (8-L-arginine vasopressin)
113-79-1 1.68mg ¥93000 2021-03-23 購入
Sigma-Aldrich Japan V0377 [Arg8]-バソプレッシン 溶液 Grade VI (synthetic), ~100?I.U./mL in 0.9% NaCl
[Arg8]-Vasopressin solution Grade VI (synthetic), ~100?I.U./mL in 0.9% NaCl
113-79-1 50iu ¥22000 2021-03-23 購入
Sigma-Aldrich Japan V0377 [Arg8]-バソプレッシン 溶液 Grade VI (synthetic), ~100?I.U./mL in 0.9% NaCl
[Arg8]-Vasopressin solution Grade VI (synthetic), ~100?I.U./mL in 0.9% NaCl
113-79-1 100iu ¥37200 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01MPB02152962 [Arg8]-バソプレッシン
[Arg 8 ]-VASOPRESSIN
113-79-1 5mg ¥47300 2021-03-23 購入

ピトレッシン 化学特性,用途語,生産方法

外観

白色の粉末

溶解性

水に溶ける。

用途

薬理・生理研究試薬。

使用

Hormone (antidiuretic).

定義

ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.

適応症

ADH (vasopressin) is released primarily in response to increases in plasma osmolarity or decreases in blood volume. It produces its antidiuretic activity in the kidney, causing the cortical and medullary parts of the collecting duct to become more permeable to water, thereby increasing water reabsorption, reducing serum osmolarity, and increasing its volume. It produces this effect by binding to a subset of vasopressin receptors called V2 that have relatively high affinity for the hormone. ADH also has actions at sites other than the kidney. V2 receptors also mediate an increase in circulating levels of two proteins involved in blood coagulation: factor VIII and von Willebrand’s factor.At higher concentrations, ADH interacts with V1 receptors to cause a general constriction of most blood vessels. It also interacts with V3 (or V1b) receptors to increase ACTH release, although the major control of ACTH release occurs through corticotropin-releasing hormone.

brand name

Pitressin (Parke-Davis).

一般的な説明

Vasopressin tannate (PitressinTannate) is a water-insoluble tannate of vasopressin administeredintramuscularly (1.5–5.0 pressor units daily)for its prolonged duration of action by the slow release ofvasopressin. It is particularly useful for patients who havediabetes insipidus, but it should never be used intravenously.

危険性

A poison.

作用機序

ADH itself is available for injections (Pitressin) but has a half-life of about 15 minutes. Desmopressin (DDAVP) is an analogue without an amino group at the first amino acid and with D-arginine instead of Larginine. This analogue is more stable and has very little pressor activity. Desmopressin can be given subcutaneously or nasally, and the effects last for 12 hours.

臨床応用

Because it is stable, desmopressin is preferred for treatments especially if pressor effects are not desired. The primary indication for therapy is central diabetes insipidus, a disorder that results when ADH secretion is reduced and that is characterized by polydipsia, polyuria, and dehydration. Desmopressin is also used to reduce primary nocturnal enuresis, or bedwetting, in children. It is useful in people with mild hemophilia A or with some types of von Willebrand’s disease, in which von Willebrand’s factor is present at low levels. In these cases, desmopressin is given when excessive bleeding occurs or before surgery to help reduce bleeding indirectly by increasing the amounts of coagulation factors. A possible adverse effect of desmopressin is water intoxication if too much is taken.
ADH antagonists, including nonpeptide analogues that may be taken orally, have been developed with specificity for each of the receptor types. In the future, those that block V1 receptors may be useful in treating hypertension, and those that block V2 receptors may be useful in any condition of excessive water retention or hyponatremia, for which so far there is no satisfactory therapeutic treatment.

安全性プロファイル

A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

ピトレッシン 上流と下流の製品情報

原材料

準備製品


ピトレッシン 生産企業

Global( 238)Suppliers
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113-79-1(ピトレッシン)キーワード:


  • 113-79-1
  • [ARG8]-VASOPRESSIN (HUMAN, BOVINE, OVINE, RAT, MOUSE)
  • [ARG8]-VASOPRESSIN
  • [ARG8]-VASOPRESSIN (AVP)
  • ANTIDIURETIC HORMONE
  • AVP
  • BETA-HYPOPHAMINE
  • β-Hypophamine
  • (ARG8)-VASOPRESSIN GRADE VI SOLUTION*APP ROX. 100 I.
  • 8-Argininevasopressin
  • Vasopressin-8-arginine
  • vasopressin tannate
  • [Arg8]-Vasopressin solution
  • β-Hypophamine, Antidiuretic hormone, Arginine vasopressin, AVP
  • [Arg8]Vasopressin (human, mouse, ovine, rat)
  • M.W. 1084.25 C46H65N15O12S2
  • Arg-Vasopressin
  • CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 (DISULFIDE BRIDGE:CYS1-CYS6)
  • 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide, 19-amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hyd
  • 3-(Phenylalanine)-8-arginineoxytocin
  • 8-L-Arginine-vasopressin
  • (ARG-8) Vasapressin
  • VASOPRESSIN, 8-L-ARGININE-
  • Vasopressin (1.71 mg) (8-L-arginine vasopressin) (COLD SHIPMENT REQUIRED)
  • ARGIPRESSINA acetate
  • Argipressin,Vasopressin,AVP,Arg8-vasopressin, >99%
  • 19-AMino-13-benzyl-7-(carbaMoylMethyl)-4-[2-[[1-[(carbaMoylMethyl)carbaMoyl]-4-guanidinobutyl]carbaMoyl]-1-pyrrolidinylcarbonyl]-16-p-hydroxybenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionaMide
  • AVP, Argipressin, LeiorMone, Pitressin, (Phe3,Arg8)-Oxytocin, Arginine Antidiuretic HorMone
  • Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bond 1-6)
  • argipressin
  • CYFQNCPRG-NH2 (DISULFIDE BRIDGE: 1-6)
  • [Arg8]バソプレッシン
  • ピトレシン
  • アルギニンバソプレシン
  • アルギニンバソプレッシン
  • 8-アルギニン-バソプレッシン
  • ピトレッシン
  • VASOPRESSIN (アルギニン型バソプレシン)
  • [ARG8]-バソプレッシン
  • (ARG8)-バソプレッシン
  • [ARG8]-バソプレッシン 酢酸塩
  • [ARG8]-バソプレッシン 溶液
  • アルギプレッシン
  • タンニン酸バソプレシン
  • 抗利尿薬
  • 血管収縮薬
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