RUBOXISTAURIN HYDROCHLORIDE

 化学構造式
169939-93-9
CAS番号.
169939-93-9
化学名:
别名:
英語名:
RUBOXISTAURIN HYDROCHLORIDE
英語别名:
LY333531 HCl;Ruboxistaurin HCl;Ruboxistaurin(LY333531HCl);Ruboxistaurin Hydrochloride;Ruboxistaurin HCl(LY333531 );Ruboxistaurin hydrochloride (LY333531);LY 333531 hydrochloride - Ruboxistaurin;LY333531 Hydrochloride(Ruboxistaurin HCl);(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione hydrochloride;(9S)-9-[(DiMethylaMino)Methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-DiMethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride
CBNumber:
CB9206452
化学式:
C28H29ClN4O3
分子量:
505.02
MOL File:
169939-93-9.mol

RUBOXISTAURIN HYDROCHLORIDE 物理性質

比旋光度 :
D25 -28.7° (c = 1.0 in ethanol)
貯蔵温度 :
Inert atmosphere,Store in freezer, under -20°C
溶解性:
DMSO:可溶10mg/mL、透明
外見 :
色:
オレンジレッド

安全性情報

WGK Germany  3

RUBOXISTAURIN HYDROCHLORIDE 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC4738
LY 333531 hydrochloride
169939-93-9 1mg ¥46000 2021-03-23 購入
Sigma-Aldrich Japan SML0693 ≥98% (HPLC)
LY-333531 hydrochloride ≥98% (HPLC)
169939-93-9 1mg ¥37900 2024-03-01 購入

RUBOXISTAURIN HYDROCHLORIDE 化学特性,用途語,生産方法

説明

LY333531 is an inhibitor of PKCβ (IC50s = 4.7 and 5.9 nM for PKCβ1 and PKCβ2, respectively). It is selective for PKCβ1 and PKCβ2 over PKCα, -γ, -δ, -ε, -ζ, and -η (IC50s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3β (GSK3β; IC50 = 39.4 nM). It inhibits neutrophil extracellular trap (NET) formation induced by phorbol 12-myristate 13-acetate (PMA; ) in primary human neutrophils when used at a concentration of 1 μM. LY333531 increases the mechanical nociceptive threshold in a rat model of diabetic hyperalgesia induced by streptozotocin (STZ; ).

使用

A protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). It is used in treatment of diabetic microvascular comp

RUBOXISTAURIN HYDROCHLORIDE 上流と下流の製品情報

原材料

準備製品


RUBOXISTAURIN HYDROCHLORIDE 生産企業

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  スペクトルデータ(1HNMR)


169939-93-9()キーワード:


  • 169939-93-9
  • Ruboxistaurin Hydrochloride
  • (9S)-9-[(DiMethylaMino)Methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-DiMethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride
  • (S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione monohydrochloride
  • Ruboxistaurin HCl
  • Ruboxistaurin(LY333531HCl)
  • LY 333531 hydrochloride - Ruboxistaurin
  • Ruboxistaurin hydrochloride (LY333531)
  • Ruboxistaurin HCl(LY333531 )
  • LY333531 HCl
  • (7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione hydrochloride
  • LY333531 Hydrochloride(Ruboxistaurin HCl)
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