1-(1,3-ベンゾジオキソール-5-イルメチル)-6,7-ジメトキシ-4-[(2S)-1-メチルピロリジン-2-イル]イソキノリン 化学特性,用途語,生産方法
説明
This newly discovered alkaloid has been isolated from Papaver macrostomum.
It crystallizes as colourless rods from C6H6 and is laevorotatory with a specific
rotation of [α]
25D - 51 ° ± 3° (c 0.892, CHCI3). It gives a complex ultraviolet
spectrum in EtOH with absorption maxima at 241,288,317 and 332 nm with
shoulders at 246, 276 and 292 nm. In the presence of dilute acid, these
absorption maxima appear at 259, 290 and 319 nm with a shoulder at 333 nm.
Macrostomine is found in the non-quaternary fraction of the alkaloidal extract.
It gives a negative Cotton effect which leads to the assumption that the
configuration is S. The alkaloid forms a crystalline methiodide with m.p.
220-230°C as slender needles when crystallized from EtOH. The structure given
has been determined from chemical and spectroscopic data.
参考文献
Minatsakanyan et ai., Tetrahedron Lett., 851 (1974)
1-(1,3-ベンゾジオキソール-5-イルメチル)-6,7-ジメトキシ-4-[(2S)-1-メチルピロリジン-2-イル]イソキノリン 上流と下流の製品情報
原材料
準備製品