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モルホリン

モルホリン 化学構造式
110-91-8
CAS番号.
110-91-8
化学名:
モルホリン
别名:
テトラヒドロパラオキサジン;テトラヒドロ-2H-1,4-オキサジン;テトラヒドロ-2H-1,4-オキザジン;モルホリン-RASTAレジン;モルホリン, 99%;モルホリン, ACS, 99.0% min;モルフォリン
英語化学名:
Morpholine
英語别名:
basf238;NA 2054;BASF 238;MORPHOLIN;Drewamine;Morphorin;Morpholine;1,4-Oxazinan;Morpholine>Morpholine (B)
CBNumber:
CB9241419
化学式:
C4H9NO
分子量:
87.12
MOL File:
110-91-8.mol

モルホリン 物理性質

融点 :
-7--5 °C (lit.)
沸点 :
126.0-130.0 °C 129 °C (lit.)
比重(密度) :
0.996 g/mL at 25 °C (lit.)
蒸気密度:
3 (vs air)
蒸気圧:
31 mm Hg ( 38 °C)
屈折率 :
n20/D 1.454(lit.)
闪点 :
96 °F
貯蔵温度 :
Store below +30°C.
溶解性:
water: miscible
外見 :
Liquid
酸解離定数(Pka):
8.33(at 25℃)
色:
APHA: ≤15
比重:
0.996
PH:
11.2 (H2O)(undiluted)
爆発限界(explosive limit):
1.4-15.2%(V)
水溶解度 :
MISCIBLE
凝固点 :
-4.9℃
Sensitive :
Hygroscopic
Merck :
14,6277
BRN :
102549
暴露限界値:
TLV-TWA 20 ppm (~70 mg/m3) (ACGIH, MSHA, and OSHA); STEL skin 30 ppm (ACGIH); IDLH 8000 ppm.
安定性::
Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Hygroscopic.
InChIKey:
YNAVUWVOSKDBBP-UHFFFAOYSA-N
CAS データベース:
110-91-8(CAS DataBase Reference)
NISTの化学物質情報:
Morpholine(110-91-8)
IARC:
3 (Vol. 47, 71) 1999
EPAの化学物質情報:
Morpholine (110-91-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  C
Rフレーズ  10-20/21/22-34
Sフレーズ  23-36-45
RIDADR  UN 2054 8/PG 1
WGK Germany  3
RTECS 番号 QD6475000
自然発火温度 590 °F
TSCA  Yes
HSコード  2934 99 90
国連危険物分類  8
容器等級  I
有毒物質データの 110-91-8(Hazardous Substances Data)
毒性 LD50 orally in female rats: 1.05 g/kg (Smyth)
消防法 危険物第4類第二石油類(水溶性)
化審法 (5)-859 優先評価化学物質
安衛法 57,57-2
PRTR法 第一種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H226 引火性の液体および蒸気 引火性液体 3 警告
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P370+P378 火災の場合:消火に...を使用すること。
P405 施錠して保管すること。

モルホリン 価格 もっと(32)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0113-0705 モルホリン 98.0+% (Capillary GC)
Morpholine 98.0+% (Capillary GC)
110-91-8 25mL ¥1500 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0113-0705 モルホリン 98.0+% (Capillary GC)
Morpholine 98.0+% (Capillary GC)
110-91-8 500mL ¥3150 2021-03-23 購入
東京化成工業 M0465 モルホリン >99.0%(GC)(T)
Morpholine >99.0%(GC)(T)
110-91-8 500mL ¥3000 2021-03-23 購入
東京化成工業 M0465 モルホリン >99.0%(GC)(T)
Morpholine >99.0%(GC)(T)
110-91-8 25mL ¥1700 2021-03-23 購入
関東化学株式会社(KANTO) 25376-01 モルホリン
Morpholine
110-91-8 500mL ¥3000 2021-03-23 購入

モルホリン 化学特性,用途語,生産方法

外観

無色~わずかにうすい黄色, 澄明の液体

定義

本品は、次の化学式で表される複素環式化合物である。

溶解性

水, アルコール, アセトン, その他ほとんどの有機溶剤と混和。水、エタノール及びアセトンに極めて溶けやすい。

解説

tetrahydro-1,4-oxazine.C4H9NO(87.12).ジエタノールアミンを70% 硫酸と加熱してつくる."アンモニア臭のある吸湿性液体.融点-4.9 ℃,沸点128~130 ℃."0.9994."1.4545.有機溶剤に易溶.水蒸気蒸留できる.ワックス,色素などの溶剤として用いられる.[CAS 110-91-8]
森北出版「化学辞典(第2版)

用途

ワックス、塗料

用途

溶剤、乳化剤原料、防錆剤

化粧品の成分用途

pH調整剤

化学的特性

Yellow liquid

化学的特性

Morpholine is a colorless liquid with a weak ammonia or fish-like odor. The odor threshold is 0.01 ppm.

化学的特性

The chemical reactivity of morpholine is attributed to the secondary amine function of the molecule; organic condensations, alkylations, and arylations readily occur, with the formation of N-substituted morpholine products of wide diversity. Ethers are relatively chemically inert, hence the oxygen is of relatively little consequence except as a member of the heterocyclic ring (Texaco Chemical Co. 1982).

物理的性質

Colorless, mobile, oily, hygroscopic, flammable liquid with a weak ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 40 μg/m3 (11 ppbv) and 25 μg/m3 (70 ppbv), respectively (Hellman and Small, 1974). Forms explosive vapors at temperatures >35 °C.

使用

Morpholine is made by dehydrating ethanolamines. Its main use is as a rubber accelerator in manufacturing tires. This process requires high temperature (300°F) and pressure, which increase the hazards. Morpholine is also used as a boiler water additive, brightener for detergents, and corrosion inhibitor, in the preservation of book paper, in waxes and polishes, and in organic synthesis.

使用

Solvent for resins, waxes, casein, dyes; morpholine compounds used as corrosion inhibitors, insecticides, antiseptics, intermediate for rubber-processing chemicals; corrosion inhibitors; waxes and polishes; optical brighteners

使用

Rubber accelerator, solvent, additive to boilerwater, waxes and polishes, optical brightener fordetergents, corrosion inhibitor, preservation of bookpaper, organic intermediate (catalyst, antioxidants,pharmaceuticals, bactericides, etc.).

調製方法

Morpholine is produced by reacting diethylene glycol, ammonia, and a small amount of hydrogen over a hydrogenation catalyst at 150-400°C and 30-400 atmospheres with the morpholine being recovered by fractional distillation. Various byproducts include 2-(2-aminoethoxy)ethanol and Af-alkylmorpholines (NRC 1981).

一般的な説明

An aqueous solution with a fishlike odor. Corrosive to tissue and moderately toxic by ingestion and inhalation.

空気と水の反応

Highly flammable. Water soluble.

反応プロフィール

MORPHOLINE dissolved in water neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

危険性

Flammable, moderate fire risk. Toxic byingestion and inhalation, irritant to skin, absorbedby skin. Eye damage and upper respiratory tractirritant. Questionable carcinogen.

健康ハザード

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

健康ハザード

Morpholine is extremely irritating, causing severe damage to the eyes, mucous membranes, and skin upon contact. Eye irritation, with transient corneal edema and temporary foggy vision are common symptoms of overexposure to vapors in the workplace. Morpholine is readily absorbed through the skin; it causes nasal irritation when inhaled, with coughing, bronchial irritation, and pulmonary edema at increasingly higher concentrations. Upon ingestion, it causes hemorrhage in the gastrointestinal tract, with possible diarrhea; liver and kidney damage may occur if sufficient amounts are ingested or inhaled. Morpholine itself is not a carcinogen on the basis of available data.

健康ハザード

Morpholine is an irritant to the eyes, skin,and mucous membranes. The irritant actionsin rabbit eyes and skin were severe. In humans the inhalation of its vapors cancause visual disturbance, nasal irritation, andcoughing. High concentrations can producerespiratory distress.

火災危険

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

工業用途

The total industrial consumption of morpholine is 11,000 metric tons/year. The largest usage for morpholine (33%) is in the rubber industry as an intermediate in the production of delayed-action accelerators for the polymerization of rubber, as stabilizers against heat-aging effects, and as bloom inhibitors in butyl rubber vulcanization. A second large proportion (25%) of morpholine production is used as an inhibitor to combat carbonic acid corrosion in condensate return lines of steam boiler systems. Morpholine is an intermediate in the manufacture of optical brighteners utilized by the soap and detergent industry. Morpholine reacts readily with fatty acids, forming soaps used in the formulation of self-polishing waxes and polishes and in coatings for the food industry. N-methyl morpholine and TV-ethyl morpholine are used as catalysts in the manufacture of polyurethane foams. Morpholine derivatives are utilized in pharmaceutical applications, as bactericides, fungicides, and herbicides, and as separating agents for oils. Other derivatives are utilized in the textile and printing industry as adjuvants, whitening agents, stabilizers, ink eradicators, and paper conditioners (Mjos 1978; NRC 1981; Texaco Chemical Co. 1982).

安全性プロファイル

Moderately toxic by ingestion, inhalation, skin contact, and intraperitoneal routes. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Can cause kidney damage. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid. A very dangerous fire hazard when exposed to flame, heat, or oxidizers; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. Mixtures with nitromethane are explosive. May ignite spontaneously in contact with cellulose nitrate of high surface area. When heated to decomposition it emits highly toxic fumes of NOx.

職業ばく露

Morpholine is used as a separating agent for volatile amines; an intermediate for textile lubricants; in the synthesis of rubber accelerators and pharmaceuticals. It is also used as a solvent; as a boiler water additive; and in the formulation of waxes, polishers and cleaners.

Carcinogenicity

Morpholine did not produce an increase in tumors in rats that inhaled from 10 to 150 ppm for 2 years. No tumors were seen in rats fed 5000 ppm morpholine for 8 weeks and observed for their lifetime. Morpholine fed concurrently with sodium nitrate increased the numbers of hepatocellular carcinomas and sarcomas of the liver and lungs of rats and mice, probably mediated through the formation of N-nitrosomorpholine. The authors concluded that morpholine itself was either weakly carcinogenic or that a nitrate from an unknown source was present. No cancers were produced when 6330 ppm morpholine was added to the drinking water of mice for their lifetimes. Concurrent exposure of morpholine plus nitrite or nitrogen dioxide increased the tumor incidence in a variety of species. In a feeding study where morpholine (0.5% in diet) and sodium nitrate were given concurrently for 23 weeks, rats showed no evidence of cancer.

環境運命予測

Biological. Heukelekian and Rand (1955) reported a 5-d BOD value of 0.0 g/g which is 0.0% of the ThOD value of 1.84 g/g.
Poupin et al. (1998) isolated a Mycobacterium strain RP1 from a contaminated activated sludge that utilized morpholine as the sole source of carbon, nitrogen, and energy. The investigators proposed the following degradation pathway: 2-hydroxymorpholine → (2-(2-aminoethoxy)acetaldehyde → 2-(2-aminoethoxy)acetate → glycolate and ethanolamine.
Chemical/Physical. In an aqueous solution, chloramine reacted with morpholine to form Nchloromorpholine (Isaac and Morris, 1983). The aqueous reaction of nitrogen dioxide (1–99 ppm) and morpholine yielded N-nitromorpholine (Cooney et al., 1987).
Slowly decomposes in the absence of oxygen.

代謝

Early reports indicated that morpholine was excreted unchanged after administration to rats (Tanaka et al 1978), dogs (Rhodes and Case 1977), and rabbits (Van Stee et al 1981). Sohn et al (1982b, 1982c) reported that approximately 80% of a radioactive dose was excreted in the urine within 24 h when administered intraperitoneally to rats, hamsters, and guinea pigs. Although 99% of the excreted dose was unmetabolized in the rat and hamster, 20% of the dose appeared in the urine of guinea pigs as N-methylmorpholine-N-oxide. N-Hydroxymorpholine and N-methylmorpholine were also detected in extracts of guinea pig tissues. Studies of the metabolism of morpholine-containing pharmaceutical agents in humans and animals indicate that the morpholine moiety may be hydroxylated or oxidized at C2 and C3, with subsequent ring cleavage (Oelschlager and Al Shaik 1985).

輸送方法

UN2054 Morpholine, Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.

純化方法

Dry morpholine with KOH, fractionally distil it, then reflux it with Na, and again fractionally distil it. Dermer & Dermer [J Am Chem Soc 59 1148 1937] precipitated it as the oxalate by adding slowly to slightly more than 1 molar equivalent of oxalic acid in EtOH. The precipitate is filtered off and recrystallised twice from 60% EtOH [1:1 salt has m 190-195o(dec)]. Addition of the oxalate to concentrated aqueous NaOH regenerated the base, which is separated and dried with solid KOH, then sodium, before being fractionally distilled. The hydrochloride has m 178-179o (from MeOH/Et2O), and the picrate has m 151.6o (from aqueous EtOH). [Beilstein 27 II 3, 27 III/IV 15.]

不和合性

Strong acids, strong oxidizers; metals, nitro compounds. Corrosive to metals; attacks copper and its compounds.

廃棄物の処理

Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

モルホリン 上流と下流の製品情報

原材料

準備製品


モルホリン 生産企業

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110-91-8(モルホリン)キーワード:


  • 110-91-8
  • 1,4-Oxazinan
  • 1,4-oxazine,tetrahydro-
  • 2H-1,4-Oxazine, tetrahydro-
  • 4H-1,4-Oxazine, tetrahydro-
  • BASF 238
  • basf238
  • Diethylenimide oxide
  • diethylenimideoxide
  • tetrahydro-4h-4-oxazine
  • tetrahydro-p-isoxazin
  • Tetryhydro-2H-1,4-oxazine
  • AKOS BBS-00003660
  • LABOTEST-BB LTBB000400
  • DIETHYLENEIMIDE OXIDE
  • DIETHYLENE OXIMIDE
  • DIETHYLENE IMIDOXIDE
  • MORPHOLINE ON RASTA RESIN
  • MORPHOLIN
  • TETRAHYDRO-P-OXAZINE
  • TETRAHYDRO-1,4-OXAZINE
  • TETRAHYDRO-2H-1,4-OXAZINE
  • Morpholine, for analysis ACS
  • Tetrahydroparaoxazine
  • Morpholine,99+%,for analysis ACS
  • Morpholine ,98% [for analysis ACS]
  • Morpholine,Tetrahydro-1,4-oxazine
  • MORPHOLINE, REAG
  • MORPHOLINE, PRACT
  • Morpholine (B)
  • Morpholine, extra pure, 99+% 1LT
  • テトラヒドロパラオキサジン
  • テトラヒドロ-2H-1,4-オキサジン
  • テトラヒドロ-2H-1,4-オキザジン
  • モルホリン-RASTAレジン
  • モルホリン, 99%
  • モルホリン, ACS, 99.0% min
  • モルフォリン
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