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RESATORVID

化学構造式
243984-11-4
CAS番号.
243984-11-4
化学名:
别名:
英語名:
RESATORVID
英語别名:
CS-1150;TAK 242;Resatorvi;RESATORVID;TAK-242(Resatorvid);Resatorvid(TAK-242);RESATORVID; TAK242; TAK 242;(R)-ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate;Ethyl (R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]-1-cyclohexenecarboxylate;ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
CBNumber:
CB92455670
化学式:
C15H17ClFNO4S
分子量:
361.82
MOL File:
243984-11-4.mol
MSDS File:
SDS

RESATORVID 物理性質

融点 :
68-69℃
沸点 :
462.0±55.0 °C(Predicted)
比重(密度) :
1.39
貯蔵温度 :
Sealed in dry,Room Temperature
溶解性:
insoluble in H2O; ≥100.6 mg/mL in EtOH; ≥18.09 mg/mL in DMSO
外見 :
個体
酸解離定数(Pka):
7.08±0.40(Predicted)

安全性情報

HSコード  2935909099

RESATORVID 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

RESATORVID 化学特性,用途語,生産方法

使用

Resatorvid is a novel selective Toll-like receptor 4 signal transduction inhibitor. Resatorvid inhibits various kinds of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF)-α , interleukin (IL)-1, IL-6, IL-10, macrophage inhibitory protein (MIP)-2 and prostaglandin E2 from lipopolysaccharide (LPS)-stimulated macrophages.

一般的な説明

A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9 nM, respectively, against LPS-induced NO, IL-6, and TNF-α production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7 mg/kg, i.p.) induced death in mice (3 mg/kg; i.v.) in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508336).

Biochem/physiol Actions

Cell permeable: yes

RESATORVID 上流と下流の製品情報

原材料

準備製品

RESATORVID 生産企業

Global( 117)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 967 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196
 sale04@alfachem.cn China 12439 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9571 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9923 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
CR Corporation Lomited
fred.wen@crcorporation.cn CHINA 12069 58

  スペクトルデータ(1HNMR)

RESATORVID(243984-11-4)1HNMR

243984-11-4()キーワード:

バリポデクト 4-({9-シクロペンチル-7,7-ジフルオロ-5-メチル-6-オキソ-5H,6H,7H,8H,9H-ピリミド[4,5-b][1,4]ジアゼピン-2-イル}アミノ)-2-フルオロ-5-メトキシ-N-(1-メチルピペリジン-4-イル)ベンズアミド 3-[(R)-2,3-ジヒドロキシプロピル]-6-フルオロ-5-[(2-フルオロ-4-ヨードフェニル)アミノ]-8-メチルピリド[2,3-d]ピリミジン-4,7(3H,8H)-ジオン 2-シクロヘキサノンカルボン酸エチル 酢酸アビラテロン 1-[2-(2-アジドエトキシ)エトキシ]エチル 2,3,4,6-テトラ-O-アセチル-D-ガラクトピラノシド (-)-ラパマイシン 2-オキソ-3-ヒドロキシ-24-ノルフリーデラ-1(10),3,5,7-テトラエン-29-酸 アビラテロン
  • 243984-11-4
  • TAK-242(Resatorvid)
  • 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester, (6R)-
  • Resatorvid(TAK-242)
  • Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-, ethyl ester, (6R)-
  • (R)-ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate
  • RESATORVID
  • TAK 242
  • (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester
  • RESATORVID; TAK242; TAK 242
  • CS-1150
  • ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
  • (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate[Resatorvid
  • Resatorvi
  • Ethyl (R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]-1-cyclohexenecarboxylate
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