バフェチニブ

バフェチニブ 価格 もっと(6)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TRCB109050	バフェチニブ Bafetinib	859212-16-1	5mg	￥33900	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCB109050	バフェチニブ Bafetinib	859212-16-1	1mg	￥21300	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01TRCB109050	バフェチニブ Bafetinib	859212-16-1	10mg	￥57000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCB109050	バフェチニブ Bafetinib	859212-16-1	25mg	￥98800	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01TRCB109050	バフェチニブ Bafetinib	859212-16-1	50mg	￥182500	2018-12-26	購入

バフェチニブ 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, チロシンキナーゼ阻害薬

説明

Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC₅₀ = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC₅₀ = 19 nM), which has been associated with resistance to imatinib in CML.

化学的特性

Pale Yellow Solid

使用

A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.

バフェチニブ 上流と下流の製品情報

原材料

準備製品

バフェチニブ 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

859212-16-1(バフェチニブ)キーワード:

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• 859212-16-1
• Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)-
• Inno 406
• Inno-406
• 4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide
• Ns 187
• Unii-nvw4Z03I9b
• Bafetinib (INNO-406)
• N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide
• Bafetinib(INNO 406,NS 187)
• (S)-N-(3-([4,5'-bipyriMidin]-2-ylaMino)-4-Methylphenyl)-4-((3-(diMethylaMino)pyrrolidin-1-yl)Methyl)-3-(trifluoroMethyl)benzaMide
• (S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide
• Bafetinib N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide
• NS-187; BAFETINIB; INNO406
• CS-239
• INNO 406 - Bafetinib
• Benil
• Rhinon
• Rinazina
• (S)-N-(3-([4,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)benzamide
• バフェチニブ
• N-[3-([4,5′-ビピリミジン]-2-イルアミノ)-4-メチルフェニル]-4-[[(3S)-3-(ジメチルアミノ)ピロリジノ]メチル]-3-(トリフルオロメチル)ベンズアミド
• NS-187
• N-[3-({[4,5'-ビピリミジン]-2-イル}アミノ)-4-メチルフェニル]-4-{[(3S)-3-(ジメチルアミノ)ピロリジン-1-イル]メチル}-3-(トリフルオロメチル)ベンズアミド