CID-49830258 化学特性,用途語,生産方法
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ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.
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ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.
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