酒石酸 エルゴタミン

酒石酸 エルゴタミン 化学構造式
379-79-3
CAS番号.
379-79-3
化学名:
酒石酸 エルゴタミン
别名:
酒石酸 エルゴタミン;酒石酸エルゴタミン;エルゴタミン·0.5(L-酒石酸);エルゴタミン·0.5[L-酒石酸];エルゴタミン酒石酸塩;エルゴタミン酒石酸塩n-水和物;エルゴタミン D-酒石酸;エルゴタミン酒石酸塩 (JP17)
英語化学名:
ERGOTAMINE TARTRATE
英語别名:
ergomar;ergostat;etin;ergam;ergate;exmigra;lingran;secagyn;secupan;femergin
CBNumber:
CB9279489
化学式:
C70H76N10O16
分子量:
1313.41
MOL File:
379-79-3.mol

酒石酸 エルゴタミン 物理性質

融点 :
~195 °C (dec.)(lit.)
比旋光度 :
D25 -125 to -155° (c = 0.4 in chloroform)
貯蔵温度 :
2-8°C
Merck :
13,3696
BRN :
6173437
CAS データベース:
379-79-3(CAS DataBase Reference)
EPAの化学物質情報:
Ergotamine tartrate (379-79-3)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  23/24/25-62-63
Sフレーズ  36/37-45
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS 番号 KE8225000
3-8-10
国連危険物分類  6.1(b)
容器等級  III
HSコード  29396200
絵表示(GHS) GHS hazard pictogramsGHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H361 生殖能または胎児への悪影響のおそれの疑い 生殖毒性 2 警告 P201, P202, P281, P308+P313, P405,P501
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。

酒石酸 エルゴタミン 価格 もっと(7)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 E0019 酒石酸エルゴタミン >98.0%(HPLC)(T)
Ergotamine Tartrate >98.0%(HPLC)(T)
379-79-3 100mg ¥6800 2022-04-26 購入
東京化成工業 E0019 酒石酸エルゴタミン >98.0%(HPLC)(T)
Ergotamine Tartrate >98.0%(HPLC)(T)
379-79-3 1g ¥23900 2022-04-26 購入
Sigma-Aldrich Japan 45510 ≥97.0% (calc. based on dry substance, NT)
Ergotamine D-tartrate ≥97.0% (calc. based on dry substance, NT)
379-79-3 250mg ¥4990 2021-03-23 購入
Sigma-Aldrich Japan 45510 ≥97.0% (calc. based on dry substance, NT)
Ergotamine D-tartrate ≥97.0% (calc. based on dry substance, NT)
379-79-3 1g ¥15700 2021-03-23 購入
Sigma-Aldrich Japan 1241506
Ergotamine tartrate
United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 1313.41 ((C33H35N5O5)2 · C4H6O6)
379-79-3 150mg ¥74200 2021-03-23 購入

酒石酸 エルゴタミン 化学特性,用途語,生産方法

解説

平滑筋収縮剤。麦角(ばっかく)から抽出されたアルカロイドで、子宮や血管の平滑筋を興奮させる。自律神経のα(アルファ)受容体を遮断して抗アドレナリン作用を示す。頭部血管に対して収縮効果が大きく、片頭痛の治療薬として用いられ、子宮収縮の目的では使用されなくなった。[幸保文治][参照項目] | アルカロイド
小学館 日本大百科全書(ニッポニカ) )

効能

抗片頭痛薬, 血管収縮薬, α1アドレナリン受容体拮抗薬, セロトニン受容体拮抗薬

説明

Ergotamine and ergometrine belong to two kinds of ergot alkaloids. Ergot (Claviceps purpurea, 麦角) is the sclerotium of ergot fungus that grows in the rye and related cereal and forage plants. The ergot is grown in the northeast and north China and Xinjiang, Jiangsu, Zhejiang, Sichuan, and other places. At present, the method of growth of ergot is inoculation cultivation.
Traditional Chinese medicine believes that ergot is tasteless, tepid, toxic, liver meridian, and kidney meridian. The traditional usage of ergot is oral administration of extractum, 2–4 ml each time, daily amount of 6–8 ml. Its dosage forms also contain infusion, pills, injection, etc. Pharmacology of Chinese Medicine records ergot can be used for uterine contraction, uterine bleeding, and postpartum hemorrhage after delivery, incomplete recovery of uterus, retrogression, etc. The Plateau Chinese herbal medicine treatment manual records that ergot can cure migraine.

化学的特性

Ergotamine tartrate is a crystalline solid.

物理的性質

Appearance: White or slightly yellow fine crystalline powder with slight hygroscopicity. Solubility: Slightly soluble in water and ethanol, insoluble in ether and chloroform.

使用

Antimigraine.

適応症

Ergometrine maleate is used in the form of extract tumor injection. As a uterotonic, ergometrine maleate is mainly used for the prevention and treatment of uterine bleeding caused by weak or poor uterine contraction after delivery or abortion, as well as the incomplete recovery of postpartum uterus to accelerate the recovery of uterus.
Ergotamine tartrate is used for the treatment of migraine in the form of tablet and parenteral solution. It also can be used for other neurogenic headache as well.

一般的な説明

Powder or liquid forms available as drugs. Used in obstetrics and in the treatment of migraine headaches.

空気と水の反応

Insoluble in water.

反応プロフィール

ERGOTAMINE TARTRATE is sensitive to prolonged exposure to heat and light. . When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat [EPA, 1998].

健康ハザード

High oral toxicity and a convulsant in humans.People with liver damage are at a greater risk.

火災危険

When heated to decomposition, ERGOTAMINE TARTRATE emits toxic fumes of nitrogen oxides. Protect from light and heat

臨床応用

Ergonovine maleate is mainly used for the prevention and treatment of the weak uterine contraction or poor contraction caused by uterine bleeding after delivery or abortion. It is also used for incomplete recovery of postpartum uterus to accelerate the recovery of the uterus.
Ergotamine tartrate is mainly used for the treatment of migraine by relieving the symptoms. However, it is only suitable for short-term usage of headache attacks, normally does not prevent migraine. The combination of ergotamine tartrate and caffeine is better than single oral administration with the mild side effects. It also can be used for other neurogenic headaches.

安全性プロファイル

Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: hallucinations, dstorted perceptions, convulsions, nausea or vomiting, blood pressure elevation. Experimental reproductive effects. Human mutation data reported. Used in production of drugs of abuse. When heated to decomposition it emits toxic fumes of NOx. See also ERGOT.

職業ばく露

(Toxicity evaluation); Suspected reprotoxic hazard, Suspected of causing genetic defects. The major uses of the ergot alkaloids fall into two categories: applications in obstetrics and treatment of migraine headaches. May be used in the production of “street” drugs

輸送方法

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

純化方法

It crystallises from MeOH. [Beilstein 25 III/IV 964.]

不和合性

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, light, and heat

酒石酸 エルゴタミン 上流と下流の製品情報

原材料

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酒石酸 エルゴタミン 生産企業

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379-79-3(酒石酸 エルゴタミン)キーワード:


  • 379-79-3
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  • ergotartrate
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  • gotaminetartrate
  • gynergen
  • lingraine
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  • neo-ergotin
  • rigetamin
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  • secupan
  • ERGOTAMINE TARTRATE
  • ERGOTAMINE D-TARTRATE, PH EUR
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  • 酒石酸 エルゴタミン
  • 酒石酸エルゴタミン
  • エルゴタミン·0.5(L-酒石酸)
  • エルゴタミン·0.5[L-酒石酸]
  • エルゴタミン酒石酸塩
  • エルゴタミン酒石酸塩n-水和物
  • エルゴタミン D-酒石酸
  • エルゴタミン酒石酸塩 (JP17)
  • 生化学
  • アルカロイド
  • インドールアルカロイド
  • αアドレナリン遮断薬
  • αアドレナリン作動薬
  • 血管拡張薬
  • 血管収縮薬
  • 鎮痛薬
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