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酢酸フタル酸セルロース

酢酸フタル酸セルロース 化学構造式
9004-38-0
CAS番号.
9004-38-0
化学名:
酢酸フタル酸セルロース
别名:
酢酸フタル酸セルロ-ス;フタル酸水素酢酸セルロース;酢酸フタル酸セルロース;セラセファート;セラセフェート (フタル酸酢酸セルロース);フタル酸酢酸セルロース;セラセフェート;セラセフェート (JP17)
英語化学名:
Cellulose acetate phthalate
英語别名:
cap-wako;CELLACEFATE;cellacetate;CELLACEFATE,NF;celluloseacetophthalate;acetylphthalylcellulose;celluloseacetylphthalate;ELLULOSE ACETATE PHTHALATE;CELLULOSE ACETATE PHTHALATE;celluloseacetatemonophthalate
CBNumber:
CB9396579
化学式:
C116H116O64
分子量:
2534.12
MOL File:
Mol file

酢酸フタル酸セルロース 物理性質

溶解性:
Practically insoluble in water, freely soluble in acetone, soluble in diethylene glycol, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
外見 :
neat
EPAの化学物質情報:
Cellulose, acetate hydrogen 1,2-benzenedicarboxylate(9004-38-0)

安全性情報

主な危険性  Xn
Rフレーズ  20/21/22-36/37/38
Sフレーズ  24/25-36-26
WGK Germany  3
RTECS 番号 FJ5692000
HSコード  39129010

酢酸フタル酸セルロース 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01USP1098355 セラセフェート (フタル酸酢酸セルロース)
Cellacefate (Cellulose Acetate Phthalate)
9004-38-0 125mg ¥64500 2018-12-26 購入
Sigma-Aldrich Japan 1098355 United States Pharmacopeia (USP) Reference Standard
Cellacefate United States Pharmacopeia (USP) Reference Standard
9004-38-0 125mg ¥57200 2018-12-25 購入
Sigma-Aldrich Japan 22192 フタル酸酢酸セルロース
Cellulose acetate phthalate
9004-38-0 100g-f ¥10600 2018-12-25 購入
Sigma-Aldrich Japan Y0001054 European Pharmacopoeia (EP) Reference Standard
Cellulose acetate phthalate European Pharmacopoeia (EP) Reference Standard
9004-38-0 y0001054 ¥33600 2018-12-25 購入
Sigma-Aldrich Japan 22192 フタル酸酢酸セルロース
Cellulose acetate phthalate
9004-38-0 500g-f ¥43500 2018-12-25 購入

酢酸フタル酸セルロース MSDS


Cellulose acetate hydrogen 1,2-benzenedicarboxylate

酢酸フタル酸セルロース 化学特性,用途語,生産方法

定義

本品は、酢酸セルロース(*)と無水フタル酸の反応生成物である。参照表示名称:酢酸セルロース

化粧品の成分用途

皮膜形成剤

効能

錠コーティング剤

化学的特性

white granular powder

化学的特性

Cellulose acetate phthalate is a hygroscopic, white to off-white, freeflowing powder, granule, or flake. It is tasteless and odorless, or might have a slight odor of acetic acid.

使用

Enteric coating in pharmaceutical products.

調製方法

Cellulose acetate phthalate is produced by reacting the partial acetate ester of cellulose with phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid.

応用例(製薬)

Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules. Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment.
Cellulose acetate phthalate is commonly applied to solid-dosage forms either by coating from organic or aqueous solvent systems, or by direct compression. Concentrations generally used are 0.5–9.0% of the core weight. The addition of plasticizers improves the water resistance of this coating material, and formulations using such plasticizers are more effective than when cellulose acetate phthalate is used alone.
Cellulose acetate phthalate is compatible with many plasticizers, including acetylated monoglyceride; butyl phthalybutyl glycolate; dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin citrate; and tripropionin. It is also used in combination with other coating agents such as ethyl cellulose, in drug controlledrelease preparations.
Therapeutically, cellulose acetate phthalate has recently been reported to exhibit experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.

安全性プロファイル

An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

安全性

Cellulose acetate phthalate is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material, free of adverse effects. Results of long-term feeding in rats and dogs have indicated a low oral toxicity. Rats survived daily feedings of up to 30% in the diet for up to 1 year without showing a depression in growth. Dogs fed 16 g daily in the diet for 1 year remained normal.

貯蔵

Slow hydrolysis of cellulose acetate phthalate will occur under prolonged adverse conditions such as high temperatures and high humidity, with a resultant increase in free acid content, viscosity, and odor of acetic acid. However, cellulose acetate phthalate is stable if stored in a well-closed container in a cool, dry place.

不和合性

Cellulose acetate phthalate is incompatible with ferrous sulfate, ferric chloride, silver nitrate, sodium citrate, aluminum sulfate, calcium chloride, mercuric chloride, barium nitrate, basic lead acetate, and strong oxidizing agents such as strong alkalis and acids.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

酢酸フタル酸セルロース 上流と下流の製品情報

原材料

準備製品


酢酸フタル酸セルロース 生産企業

Global( 67)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21956 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23959 58
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3579 66
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9851 79
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 info@yuhaochemical.com China 9406 52
Beijing Taiya Jie Technology Development Co., Ltd. 13552411790、021-37288178 QQ:1904959239 / 2938065042
021-37288178 E-mail:postmaster@tyjchem.cn China 1496 55
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email
manager@chinaskyrun.com sales@chinaskyrun.com China 12126 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 24991 65

9004-38-0(酢酸フタル酸セルロース)キーワード:


  • 9004-38-0
  • ELLULOSE ACETATE PHTHALATE
  • Cellulose Acetate Phthalate (CAP)
  • celluloseacetophthalate
  • celluloseacetylphthalate
  • Cellulose Acetate Phthalate API
  • Cellulose acetate phthalate NF
  • CELLACEFATE
  • Cellulose acetate hydrogen 1,2-benzenedicarboxylate
  • CELLULOSE ACETATE HYDROGEN PHTHALATE
  • CELLULOSE ACETATE PHTHALATE
  • CelluloseAcetatePhthalate(Cellacefate)
  • Cellulose acetate hydrogen phthalate, acetyl content 17.0-22.0%
  • CELLACEFATE,NF
  • CELLULOSE ACETATE PHTHALATE extrapure
  • Cellacefate (125 mg) (Cellulose Acetate Phthalate)
  • acetylphthalylcellulose
  • cap-wako
  • cellacetate
  • celluloseacetatemonophthalate
  • 酢酸フタル酸セルロ-ス
  • フタル酸水素酢酸セルロース
  • 酢酸フタル酸セルロース
  • セラセファート
  • セラセフェート (フタル酸酢酸セルロース)
  • フタル酸酢酸セルロース
  • セラセフェート
  • セラセフェート (JP17)
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