AMD3100 八塩酸塩 水和物

AMD3100 八塩酸塩 水和物 価格 もっと(3)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC3299	AMD 3100 octahydrochloride	155148-31-5	10mg	￥59000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC3299	AMD 3100 octahydrochloride	155148-31-5	50mg	￥248000	2024-03-01	購入
Sigma-Aldrich Japan	A5602	AMD3100 八塩酸塩 水和物 ≥97% (NMR), solid AMD3100 octahydrochloride hydrate ≥97% (NMR), solid	155148-31-5	5mg	￥29500	2024-03-01	購入

AMD3100 八塩酸塩 水和物 化学特性,用途語,生産方法

使用

Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively - See more at: http://www.selleckchem.com/products/plerixafor-8hcl-db06

一般的な説明

A symmetrical bicyclam compound that antagonizes CXCL12 (SDF1) binding to CXCR4 (IC₅₀ = 108 and 245 nM using rat and human CXCR4, respectively) and inhibits SDF1-induced Ca²⁺ flux (by 100% at 100 ng/ml in SUP-T1 and THP-1 cultures) as well as CXCR4-, but not CCR5-, mediated HIV infection (IC₅₀ ≤200 nM), while enhancing the binding of SDF1 to CXCR7 (by ~60% at 1 mM with CXCR7-expressing HEK293T cells) and SDF1-induced β-arrestin recruitment to CXCR7 (EC₅₀ = 6.48 and 11.8 nM, in the presence and absence of 10 μM AMD3100, respectively). Administration AMD3100 via intravenous infusion is also reported to result in hematopoietic stem cell mobilization in humans, dogs, and mice in vivo. Exhibits no inhibitory effects against chemokine-induced signaling via CXCR1/2/3 or CCR1/2/3/4/5/6/7/8/9.

生物活性

Highly selective CXCR4 chemokine receptor antagonist (IC 50 values are 0.02 - 0.13 and > 25 μ M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC 50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo .

臨床応用

Plerixafor hydrochloride, a chemokine CXCR4 (SDF-1) antagonist, was launched by Genzyme for the treatment of enhancing mobilization of hematopoietic stem cells for autologous transplantation in patients with lymphoma and enhancing mobilization of hematopoietic stem cells for transplantation in patients with multiple myeloma. Being a CXCR4 antagonist, a specific cellular chemokine receptor, plerixafor triggers the rapid movement of stem cells out of the bone marrow and into circulating blood where the stem cells can be collected for use in stem cell transplants. Regarding its use for cardiac applications, some clinical data suggests that the presence of stem cells circulating in the bloodstream or directly injected into the hearts of patients who have suffered a heart attack may result in improved cardiac function.

AMD3100 八塩酸塩 水和物 上流と下流の製品情報

原材料

準備製品

AMD3100 八塩酸塩 水和物 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2259	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	+8615065888978	admin@hsnordpharma.com	China	92	58

155148-31-5(AMD3100 八塩酸塩 水和物)キーワード:

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• 155148-31-5
• SID791
• AMD3100
• BISCYCLAM
• JM3100
• AMD3100 OCTAHYDROCHLORIDE HYDRATE ANHYDROUS
• amd3100 octahydrochloride hydrate
• 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride, min. 95 % (NMR)
• AMD3100 hydrate octahydrochloride
• JM3100, SID791, 1,1μ-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride
• 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]
• 1,1'-[1,4-PHENYLENEBIS(METHYLENE)]BIS-1,4,8,11-TETRAAZACYCLOTETRADECANE OCTAHYDROCHLORIDE
• 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-, octahydrochloride
• Bicyclam
• Plerixafor hydrochloride
• Plerixafor hcl
• Plerixafor (hydrochloride hydrate)
• Plerixafor HCL(JM 3100)
• Plerixafor 8HCl (DB06809)
• Plerixafor (octahydrochloride)
• Plerixafor 8HCl (AMD3100 8HCl)
• Plerixafor(SynonyM: AMD3100 octahydrochloride hydrate)
• 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8)
• JM 3100 8HCl
• AMD 3100 octahydrochloride(8HCl)
• AMD 3100 octahydrochloride, >=98%
• Plerixafor 8HCl
• 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride hydrate
• AMD3100 HCl
• JM3100 octahydrochloride
• SID791 octahydrochloride
• AMD3100 八塩酸塩 水和物
• 塩酸プレリキサフォル
• AMD-3100
• 1,1′-(1,4-フェニレンビスメチレン)ビス(1,4,8,11-テトラアザシクロテトラデカン)・8塩酸塩
• 6,6′-ビ(1,4,8,11-テトラアザシクロテトラデカン)
• 3,3',6,6',10,10',13,13'-オクタアザ-1,1'-ビ(シクロテトラデカン)
• ビスシクラム
• 6,6′-ビ[1,4,8,11-テトラアザシクロテトラデカン]
• 13,13′-ビ[1,4,8,11-テトラアザシクロテトラデカン]