ノボビオシンナトリウム

ノボビオシンナトリウム 価格 もっと(26)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01MPB02155957	ノボビオシンナトリウム Novobiocin, Sodium Salt, Potency: - 900 ug/mg, Crystalline	1476-53-5	1g	￥11100	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCN888500	ノボビオシンナトリウム塩 Novobiocin Sodium Salt	1476-53-5	1g	￥25800	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01MPB02155957	ノボビオシンナトリウム Novobiocin, Sodium Salt, Potency: - 900 ug/mg, Crystalline	1476-53-5	5g	￥38900	2024-03-01	購入
関東化学株式会社(KANTO)	49834-03	ノボビオシンナトリウム標準品 Novobiocin sodium standard	1476-53-5	250mg	￥18000	2024-03-01	購入
関東化学株式会社(KANTO)	28562-62	ノボビオシン一ナトリウム Novobiocin monosodium salt	1476-53-5	1g	￥10000	2024-03-01	購入

ノボビオシンナトリウム 化学特性,用途語,生産方法

外観

白色〜うすい黄褐色, 結晶性粉末〜粉末

溶解性

水(二酸化炭素を除いた水)に溶ける

効能

抗生物質

化学的特性

crystalline

使用

Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.

臨床応用

The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.
Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.

安全性プロファイル

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.

純化方法

The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]

ノボビオシンナトリウム 上流と下流の製品情報

原材料

準備製品

ノボビオシンナトリウム 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3635	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58

1476-53-5(ノボビオシンナトリウム)キーワード:

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• 1476-53-5
• albamycin(capsule)
• Albamycinsodium
• Cathomycinsodium
• Cathomycinsodiumlyovac
• Monosodiumnovobiocin
• Novobiocin,sodiumderiv.
• Novobiocinmonosodium
• N-[7-[(3-O-Carbamoyl-4-O,5-C-dimethyl-6-deoxy-β-L-lyxo-hexopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-sodiooxy-3-(3-methyl-2-butenyl)benzamide
• Benzamide, N-7-3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.alpha.-L-lyxo-hexopyranosyloxy-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
• 7-[4-(Carbamoyloxy)-tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yl]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-, sodium salt
• Albadry
• Albycin sodium
• Antibiotic from streptomyces spheroides
• Benzamide, N-[7-[[3-o-(aminocarbonyl)-6-deoxy-5-C-methyl-4-o-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
• Novobiocin sodiuM(AlbaMycin)
• N-[7-[[3-O-(AMinocarbonyl)-6-deoxy-5-C-Methyl-4-O-Methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-Methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-Methyl-2-butenyl)benzaMide MonosodiuM salt
• NSC 2382
• Crystallinic acid MonosodiuM salt
• Robicina
• Novobiocin-Na-salt research grade
• N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-benzamide, sodium salt (1:1)
• Novobiocin Sodium (U-6591)
• Sodiumalbamycin
• Sodiumnovobiocin
• Vulcamycin
• MSRV SELECTIVE SUPPLEMENT
• NOVOBIOCIN MONOSODIUM SALT
• NOVOBIOCIN NA-SALT
• NOVOBIOCIN SODIUM SALT
• STREPTONIVICIN
• N-[7-[(3-O-カルバモイル-4-O,5-C-ジメチル-6-デオキシ-β-L-lyxo-ヘキソピラノシル)オキシ]-4-ヒドロキシ-8-メチル-2-オキソ-2H-1-ベンゾピラン-3-イル]-4-ソジオオキシ-3-(3-メチル-2-ブテニル)ベンズアミド
• ノボビオシンナトリウム
• ノボビオシンナトリウム標準品
• ノボビオシン一ナトリウム
• ノボビオシンナトリウム塩
• NOVOBIOCIN ナトリウム
• ノボビオシン ナトリウム塩
• ノボビオシンナトリウム (JAN)
• (3S,4S,5R,6S)-5-ヒドロキシ-6-({4-ヒドロキシ-8-メチル-3-[3-(3-メチルブタ-2-エン-1-イル)-4-(ソジオオキシ)ベンズアミド]-2-オキソ-2H-クロメン-7-イル}オキシ)-3-メトキシ-2,2-ジメチルオキサン-4-イル カルバマート
• 生活関係標準物質
• 食料品