チザニジン
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- CAS番号.
- 51322-75-9
- 化学名:
- チザニジン
- 别名:
- 5-クロロ-4-[(4,5-ジヒドロ-1H-イミダゾール)-2-イルアミノ]-2,1,3-ベンゾチアジアゾール;5-クロロ-N-[(4,5-ジヒドロ-1H-イミダゾール)-2-イル]2,1,3-ベンゾチアジアゾール-4-アミン;5-クロロ-N-(4,5-ジヒドロ-1H-イミダゾール-2-イル)-2,1,3-ベンゾチアジアゾール-4-アミン;5-クロロ-4-(2-イミダゾリン-2-イルアミノ)-2,1,3-ベンゾチアジアゾール;チザニジン
- 英語名:
- Tizanidine
- 英語别名:
- AB-021;C07452;TERNELIN;SIRDALUD;ZANAFLEX;DS-103-282;TIZANIDINE;TIZANIDINE HCL;Tizanidine USP/EP/BP;TIZANIDINE HCL 2% GRANULES
- CBNumber:
- CB9670538
- 化学式:
- C9H8ClN5S
- 分子量:
- 253.71
- MOL File:
- 51322-75-9.mol
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安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
Xn |
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| Rフレーズ |
22-36/37/38 |
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| Sフレーズ |
26-36 |
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| WGK Germany |
3 |
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| RTECS 番号 |
DK9910000 |
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| 毒性 |
LD50 orally in mice: 235 mg/kg (Sayers) |
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| 絵表示（GHS） |
 
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| 注意喚起語 |
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| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H361 |
生殖能または胎児への悪影響のおそれの疑い |
生殖毒性 |
2 |
警告 |
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P201, P202, P281, P308+P313, P405,P501 |
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| 注意書き |
| P201 |
使用前に取扱説明書を入手すること。 |
| P202 |
全ての安全注意を読み理解するまで取り扱わないこ と。 |
| P281 |
指定された個人用保護具を使用すること。 |
| P308+P313 |
暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。 |
| P405 |
施錠して保管すること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
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チザニジン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
チザニジン 化学特性,用途語,生産方法
効能
筋弛緩薬, α2アドレナリン受容体作動薬
説明
Tizanidine is a centrally-acting muscle relaxant useful in the treatment of muscle
spasms and a variety of spastic conditions.
使用
Labeled Tizanidine, intended for use as an internal standard for the quantification of Tizanidine by GC- or LC-mass spectrometry.
定義
ChEBI: 2,1,3-Benzothiadiazole substituted at C-4 by a Delta1-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
作用機序
Tizanidine is a centrally active muscle relaxant analogue of clonidine that is approved for use in reducing spasticity associated with cerebral or spinal cord
injury. Its mechanism of action for reducing spasticity suggests presynaptic inhibition of motor neurons at the α2-adrenergic receptor sites, reducing the release of
excitatory amino acids and inhibiting facilitatory ceruleospinal pathways, thus resulting in a reduction in spasticity. Tizanidine only has a small fraction of the
antihypertensive action of clonidine, presumably because of action at a selective subgroup of α2C-adrenoceptors, which appear to be responsible for the analgesic and
antispasmodic activity of imidazoline α2-agonists(20).
臨床応用
Tizanidine is a centrally acting adrenergic α2 receptor agonist used to treat chronic muscle
spasticity conditions, such as multiple sclerosis.
副作用
Postulated mechanisms include α2 receptor-mediated decreased release of norepinephrine and
serotonin from spinal interneurons. Tizanidine is structurally related to the α2 agonist
clonidine that is used to treat hypertension; however, the blood pressure–lowering potency of
tizanidine is approximately 10 to 20% that of clonidine. Nevertheless, patients may experience
hypotension with tizanidine, together with muscle weakness, that may result in dizziness and falls
in mobile patients. Tizanidine is rapidly and almost completely absorbed from the gastrointestinal
tract; however, the estimated bioavailability is only 10 to 15% because of extensive first-pass
metabolism, mainly by CYP1A2, which results in oxidative degradation of the imidazoline ring
and hydroxylation of the aromatic system. Elevated liver enzyme values are not frequent
with tizanidine use. Hepatic injury and death because of liver failure have been reported,
however, and this complication should be considered in view of its marginal antispasmodic
efficacy. Other frequently reported side effects of tizanidine are drowsiness and dry
mouth. Clonidine also has been used to treat spasticity; however, even less high-quality clinical
study data are available for this agent.
チザニジン 上流と下流の製品情報
原材料
準備製品
チザニジン 生産企業
Global( 132)Suppliers
51322-75-9(チザニジン)キーワード:
- 51322-75-9
- 3-benzothiadiazole,5-chloro-4-(2-imidazolin-2-ylamino)-1
- 3-benzothiadiazole-4-amine,5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-1
- 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
- 5-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOLE-4-AMINE HYDROCHLORIDE
- 5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-2,1,3-benzothiadiazole-4-amine
- (5-CHLORO-BENZO[1,2,5]THIADIAZOL-4-YL)-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-AMINE
- AB-021
- DS-103-282
- SIRDALUD
- TERNELIN
- TIZANIDINE
- TIZANIDINE HCL
- 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-8-thia-7,9-diazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine
- ZANAFLEX
- 5-Chloro-4-(2-imidazolin-2-ylamino)benzo-2,1,3-thiadiazole
- 5-CHLORO-N-(4,5-DIHYDR-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOLE-4-AMINE
- 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
- 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-
- 2,1,3-Benzothiadiazole-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-
- C07452
- 2,1,3-Benzothiadiazol-4-aMine, 5-chloro-N-(4,5-dihydro-1H-iMidazol-2-yl)-
- 5-chloro-N-(4,5-dihydro-1H-iMidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-aMine hydrochloride
- Tizanidine USP/EP/BP
- TizanidineQ: What is
Tizanidine Q: What is the CAS Number of
Tizanidine Q: What is the storage condition of
Tizanidine Q: What are the applications of
Tizanidine
- TIZANIDINE HCL 2% GRANULES
- 5-クロロ-4-[(4,5-ジヒドロ-1H-イミダゾール)-2-イルアミノ]-2,1,3-ベンゾチアジアゾール
- 5-クロロ-N-[(4,5-ジヒドロ-1H-イミダゾール)-2-イル]2,1,3-ベンゾチアジアゾール-4-アミン
- 5-クロロ-N-(4,5-ジヒドロ-1H-イミダゾール-2-イル)-2,1,3-ベンゾチアジアゾール-4-アミン
- 5-クロロ-4-(2-イミダゾリン-2-イルアミノ)-2,1,3-ベンゾチアジアゾール
- チザニジン
- αアドレナリン作動薬
- 筋弛緩薬
- 鎮痙薬