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ゼラチン,板状

ゼラチン,板状 化学構造式
9000-70-8
CAS番号.
9000-70-8
化学名:
ゼラチン,板状
别名:
ゼラチン;ゼルフォーム;ゲラチン;ゼルフィルム;スポンゼル;ゼラチン末;ゼラチン,板状;ゼラチン,粉末;ゼラチン(粉末);ゼラチン, ブタ皮膚由来;メドジェル® シート II (PI9);ゼラチン, ウシ骨由来;ゼラチン, LIQUID;メドジェル® 粒子 II (PI5);メドジェル® シート II (PI5);日本薬局方 精製ゼラチン「製造専用」 ビーマトリックス® ゼラチン HG;日本薬局方ゼラチン「製造専用」 ビーマトリックス® ゼラチン LS-250;日本薬局方 ゼラチン(製造専用);PRIONEX® 高純度 TYPE A;ゼラチン FROM COLD WATER FISH SKIN
英語化学名:
Gelatin
英語别名:
gt;Galfoam;gelfoam;GELATIN;Gelfilm;Spongel;puragel;GELATINA;GELATINE;gelatins
CBNumber:
CB9680379
化学式:
C6H12O6
分子量:
0
MOL File:
Mol file

ゼラチン,板状 物理性質

貯蔵温度 :
2-8°C
溶解性:
H2O: 67 mg/mL at 50 °C, slightly hazy, slightly yellow
外見 :
powder
酸解離定数(Pka):
pKa 3.7to4.5(H2O t=25 I=0.00 N2atmosphere) (Uncertain)
色:
Pale yellow to beige
PH:
4.0-6.0 (25℃, 67mg/mL in H2O)
水溶解度 :
SOLUBLE IN HOT WATER
Merck :
13,4393
安定性::
Stable. Hygroscopic. Incompatible with strong oxidizing agents.
EPAの化学物質情報:
Gelatins(9000-70-8)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  24/25-36/37/39-27-26
WGK Germany  3
RTECS 番号 LX8580000
3
TSCA  Yes
HSコード  35030010
有毒物質データの 9000-70-8(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: > 5000 mg/kg

ゼラチン,板状 価格 もっと(60)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MPB02901771 ゼラチン, ブタ皮膚由来
Gelatin, from Porcine Skin
9000-70-8 100g ¥7300 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01MPB02901771 ゼラチン, ブタ皮膚由来
Gelatin, from Porcine Skin
9000-70-8 500g ¥10100 2018-12-26 購入
関東化学株式会社(KANTO) 17009-31 ゼラチン末
Gelatin, powder
9000-70-8 25g ¥1800 2018-12-13 購入
関東化学株式会社(KANTO) 17009-01 ゼラチン末
Gelatin, powder
9000-70-8 500g ¥3100 2018-12-13 購入
Sigma-Aldrich Japan 39465 ゼラチン from porcine skin for microbiology, ultrahigh gel strength
Gelatin from porcine skin for microbiology, ultrahigh gel strength
9000-70-8 500g ¥13900 2018-12-25 購入

ゼラチン,板状 MSDS


Gelatin

ゼラチン,板状 化学特性,用途語,生産方法

外観

粉末状 白色から淡黄褐色

定義

本品は、動物の皮膚、白色結合組織及び骨から得られるコラーゲン(*)を部分加水分解して得られる生成物である。参照表示名称:コラーゲン

溶解性

水に溶解

用途

微生物培養の固定化剤。ゼラチン-ベロナール緩衝液、ゼラチンディスクによる菌株の保存、ゼラチンスライドの作成(病理組織標本)、錠剤、トローチ,坐剤の基礎剤、人工臓器など。

用途

立体臓器、幹細胞 /1PS細胞、再生医療、ドラッグデリバリー、バイオマテリアル

用途

・ 医薬品の安定化・ 再生医療、ティッシュエンジニアリング

用途

食品用、止血剤、培地

化粧品の成分用途

ヘアコンディショニング剤、酵素剤、結合剤、口腔衛生剤、皮膚コンディショニング剤、親水性増粘剤

説明

Gelatin does not occur in nature as such, but is derived by hydrolysis of collagen, the chief protein component in connective tissues of the animal body. Extraction of gelatin for use as a glue by cooking hides dates back to the earliest recorded history of man and appears in the literature of the items up to the present day. During the early years of the Napoleonic era it was manufactured on a large scale in an attempt to alleviate the food shortages resulting from the English naval blockade of Europe. Gelatin was first manufactured in the U.S. in 1809. In 1845 a U.S. patent was granted for a gelatin which contained all the ingredients fitting it for table use, and required only the addition of hot water and subsequent cooling to prepare it for serving.
Quantitatively, collagen is concentrated in the skin, the bone of the skeletal system and the tendons attaching muscles to the skeleton, although it occurs throughout all of the tissues and organs to a lesser degree. Chemically, collagen and gelatin are virtually indistinguishable, but the process of collagen extraction results in converting the fibrous, water-insoluble, highly organized macromolecules (tropocollagens) irreversibly into gelatin which has dissimilar physical characteristics. Variations in gelatin properties due to source and treatment make it a highly diverse, heterogeneous substance, particularly with regard to molecular weight.
The major sources of collagen are cattle hides, pig skins and bones. The resulting gelatin is of two types commonly designated A and B, depending upon which of two processes are used to convert the collagen into gelatin. Type A gelatin is derived primarily from pig skin by acid processing; it has an isoelectric point between pH 7 and pH 9. Type B is from cattle hides and bones by alkaline or lime processing and has an isoelectric point between pH 4.7 and pH 5.1. Gelatin from different sources and as prepared by the different processes exhibits small differences in amino acid composition as shown in the following table. The nutritionally essential amino acid, tryptophan, is absent in gelatin. Gelatin also is unusual in that it contains large proportions of glycine, proline and hydroxyproline, and a small percentage of hydroxylysine, an amino acid rare in proteins. (SCOGS, 1975).
The major use of gelatin in the U.S. is in food products, principally in gelatin desserts, meat products, consommes, marshmallows, candies, bakery and dairy products and ice cream. A substantial portion of each year’s production (imported and domestic) is also used in the pharmaceutical, photographic and paper industries. (SCOGS, 1975).
Gelatin is colorless or slightly yellow, transparent, brittle, practically odorless, tasteless, presenting as sheets, flakes or a coarse powder. On being warmed, gelatin disperses into the water resulting in a stable suspension. Water solutions of gelatin will form a reversible gel if cooled below the specific gel point of gelatin. The gel point is dependent on the source of the raw material. Gelatin extracted from the tissues of warm-blooded animals will have a gel point in the range of 30°C - 35°C. Gelatin extracted from the skin of cold-water ocean fish will have a gel point in the range of 5°C - 10°C. Gelatin is soluble in aqueous solutions of polyhydric alcohols such as glycerin and propylene glycol.

化学的特性

white to slightly yellow powder, also knownas glutin,is a protein found in many animal tissues including skin, cartilage, horn, and bone. Gelatin is used in leather dressings, in photography, in metallurgy, in the plastics industry, and in pharmaceuticals.

化学的特性

Gelatin occurs as a light-amber to faintly yellow-colored, vitreous, brittle solid. It is practically odorless and tasteless, and is available as translucent sheets, flakes, and granules, or as a coarse powder.

使用

Gelatin is a protein that functions as a gelling agent. it is obtained from collagen derived from beef bones and calf skin (type b) or pork skin (type a). type b is derived from alkali-treated tissue and has an isoelectric point between ph 4.7 and 5.0. type a is derived from acid-treated tissue and has an isoelectric point between ph 7.0 and 9.0. it forms thermally reversible gels which set at 20°c and melt at 30°c. the gel strength is measured by means of a bloom gellometer and ranges from 50 to 300 with a 250 bloom being the most common. it is used in desserts at 8–10% of the dry weight, in yogurt at 0.3–0.5%, in ham coatings at 2–3%, and in confectionery and capsules at 1.5–2.5%.

使用

gelatin is used as a natural sealant against moisture loss and as a formulation thickener. The films produced by gelatin are tacky when moist and hard, and brittle when dry. It is obtained by the partial hydrolysis of mature collagen derived from the skin, connective tissue, and bones of animals. It does not have the waterbinding ability of soluble collagen.

使用

As stabilizer, thickener and texturizer in food; manufacture of rubber substitutes, adhesives, cements, lithographic and printing inks, plastic Compounds, artificial silk, photographic plates and films, matches, light filters for mercury lamps; clarifying agent; in hectographic masters; sizing paper and textiles; for inhibiting crystallization in bacteriology, for preparing cultures. Pharmaceutic aid (suspending agent; encapsulating agent; tablet binder; tablet and coating agent).

定義

Amixture of proteins obtained by hydrolysis of collagen by boiling skin, ligaments, tendons, etc. Its production differs from that of animal glue in that the raw materials are selected, cleaned, and treated with special care so that the product is cleaner

調製方法

Gelatin is extracted from animal tissues rich in collagen such as skin, sinews, and bone. Although it is possible to extract gelatin from these materials using boiling water, it is more practical to first pretreat the animal tissues with either acid or alkali. Gelatin obtained from the acid process is called type A, whereas gelatin obtained from the alkali process is called type B.
The acid-conditioning process (manufacture of type A gelatin) is restricted to soft bone ossein (demineralized bones), sinew, pigskin, calfskin and fish skins for reasons of gaining sufficient yield. The material is cut in pieces and washed in cold water for a few hours to remove superficial fat. It is then treated with mineral acid solutions, mainly HCl or H2SO4, at pH 1–3 and 15–20°C until maximum swelling has occurred. This process takes approximately 24 hours. The swollen stock is then washed with water to remove excess acid, and the pH is adjusted to pH 3.5–4.0 (pigskin, fish skin) or 2.0–3.5 (all other tissues) for the conversion to gelatin by hot-water extraction.
The hydrolytic extraction is carried out in a batch-type operation using successive portions of hot water at progressively higher temperatures (50–75°C) until the maximum yield of gelatin is obtained. The gelatin solution is then filtered through previously sterilized cellulose pads, deionized, concentrated to about 20–25% w/v and sterilized by flashing it to 138°C for 4 seconds. The dry gelatin is then formed by chilling the solution to form a gel, which is air-dried in temperature-controlled ovens. The dried gelatin is ground to the desired particle size.
In the alkali process (liming), demineralized bones (ossein) or cattle skins are usually used. The animal tissue is held in a calcium hydroxide (2–5% lime) slurry for a period of 2–4 months at 14–18°C. At the end of the liming, the stock is washed with cold water for about 24 hours to remove as much of the lime as possible. The stock solution is then neutralized with acid (HCl, H2SO4, H3PO4) and the gelatin is extracted with water in an identical manner to that in the acid process, except that the pH is kept at values between 5.0–6.5 (neutral extraction).
During the preparation of the bovine bones used in the production of gelatin, specified risk materials that could contain transmissible spongiform encephalopathies (TSEs) vectors are removed. TSE infectivity is not present in pharmaceutical grade gelatin.

定義

A pale yellow protein obtained from the bones, hides, and skins of animals, which forms a colloidal jelly when dissolved in hot water. It is used in jellies and other foods, to make capsules for various medicinal drugs, as an adhesive and sizing medium, and in photographic emulsions.

一般的な説明

Gelatin, NF, is a protein obtained by the partial hydrolysis of collagen, an albuminoid found in bones, skin, tendons, cartilage, hoofs, and other animal tissues. Gelatin is used in the preparation of capsules, in the coating of tablets, and, with glycerin, as a vehicle for suppositories. It has also been used as a vehicle when slow absorption is desired for drugs.

农业用途

Gelatin is a colorless or pale yellow water-soluble protein obtained by boiling collagen with water and evaporating the water. It is an ingredient in jellies and baked goods. It is also used to make medicinal capsules, and coat photographic films.

応用例(製薬)

Gelatin is widely used in a variety of pharmaceutical formulations, including its use as a biodegradable matrix material in an implantable delivery system, although it is most frequently used to form either hard or soft gelatin capsules.
Gelatin capsules are unit-dosage forms designed mainly for oral administration. Soft capsules on the market also include those for rectal and vaginal administration. Hard capsules can be filled with solid (powders, granules, pellets, tablets, and mixtures thereof), semisolid and liquid fillings, whereas soft capsules are mainly filled with semisolid or liquid fillings. In hard capsules, the active drug is always incorporated into the filling, while in soft capsules the drug substance can also be incorporated into the thick soft capsule shell. Gelatin is soluble in warm water (>30°C), and a gelatin capsule will initially swell and finally dissolve in gastric fluid to release its contents rapidly.
Hard capsules are manufactured in two pieces by dipping lubricated stainless steel mold pins into a 45–55°C gelatin solution of defined viscosity, which depends on the size of the capsules and whether cap or body are to be formed. The gelatin is taken up by the pins as a result of gelation, and the resulting film thickness is governed by the viscosity of the solution. The capsule shells are passed through a stream of cool air to aid setting of the gelatin, and afterwards they are slowly dried with large volumes of humidity controlled air heated to a few degrees above ambient temperature and blown directly over the pins. The capsule halves are removed from their pins, trimmed and fitted together. Gelatin that is used to produce hard capsules may contain various coloring agents and antimicrobial preservatives. Surfactants may be present in small quantities in the shells being a residue of the pin lubricant. However, the use of preservatives is no longer encouraged in line with current GMP principles. Capsule shells may be treated with formaldehyde to make them insoluble in gastric fluid. Standard capsules vary in volume from 0.13 to 1.37 mL. For veterinary use, capsules with a volume between 3 and 28mL are available, and capsules with a capacity of 0.025mL are available for toxicity studies in rats. In contrast to two-piece hard capsules, soft gelatin capsules are manufactured, filled and sealed in one process. The gelatin used to form the soft shells has a lower gel strength than that used for hard capsules, and the viscosity of the solutions is also lower, which results in more flexible shells. Additives to soft shell formulations are plasticizers such as polyalcohols (glycerin, propylene glycol, polyethylene glycol). Sorbitol can be added as moisturizing agent, whereby the larger amount of water will act as plasticizer. Coloring and opacifying agents are also added. The filling can interact with the gelatin and the plasticizer chemically. There may be migration of filling components into the shell and plasticizer from the shell into the filler. These interactions have to be taken into account during the formulation of the gelatin shell and the filling. The main method to produce soft gelatin capsules is the rotary die method (RP Scherer), and an alternative method for small volumes of round capsules is the Globex system (Industrial Techno-logic Solutions Ltd). Soflet Gelcaps (Banner Pharmacaps) are tablets that have been coated with a gelatin film.
Gelatin is also used for the microencapsulation of drugs, where the active drug is sealed inside a microsized capsule or beadlet, which may then be handled as a powder. The first microencapsulated drugs (beadlets) were fish oils and oily vitamins in gelatin beadlets prepared by coacervation.
Low-molecular-weight gelatin has been investigated for its ability to enhance the dissolution of orally ingested drugs. Ibuprofen–gelatin micropellets have been prepared for the controlled release of the drug. Other uses of gelatin include the preparation of pastes, pastilles, pessaries, and suppositories. In addition, it is used as a tablet binder and coating agent, and as a viscosity-increasing agent for solutions and semisolids.
Therapeutically, gelatin has been used in the preparation of wound dressings and has been used as a plasma substitute, although anaphylactoid reactions have been reported in the latter application. Absorbable gelatin is available as sterile film, ophthalmic film, sterile sponge, sterile compressed sponge, and sterile powder from sponge. Gelatin sponge has hemostatic properties.
Gelatin is also widely used in food products and photographic emulsions. 8

安全性プロファイル

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

安全性

Gelatin is widely used in a variety of pharmaceutical formulations, including oral and parenteral products.
In general, when used in oral formulations gelatin may be regarded as a nontoxic and nonirritant material. However, there have been rare reports of gelatin capsules adhering to the esophageal lining, which may cause local irritation. Hypersensitivity reactions, including serious anaphylactoid reactions, have been reported following the use of gelatin in parenteral products.
There have been concerns over the potential spread of BSE/TSE infections through bovine derived products. However, the risk of such contamination of medicines is extremely low.
LD50 (rat, oral): 5 g/kg
TDLo (mouse, IP): 700 mg/kg

貯蔵

Dry gelatin is stable in air. Aqueous gelatin solutions are also stable for long periods if stored under cool conditions but they are subject to bacterial degradation. At temperatures above about 50°C, aqueous gelatin solutions may undergo slow depolymerization and a reduction in gel strength may occur on resetting. Depolymerization becomes more rapid at temperatures above 65°C, and gel strength may be reduced by half when a solution is heated at 80°C for 1 hour. The rate and extent of depolymerization depends on the molecular weight of the gelatin, with a lower-molecular-weight material decomposing more rapidly.Dry gelatin is stable in air. Aqueous gelatin solutions are also stable for long periods if stored under cool conditions but they are subject to bacterial degradation.(4) At temperatures above about 50°C, aqueous gelatin solutions may undergo slow depolymerization and a reduction in gel strength may occur on resetting. Depolymerization becomes more rapid at temperatures above 65°C, and gel strength may be reduced by half when a solution is heated at 80°C for 1 hour. The rate and extent of depolymerization depends on the molecular weight of the gelatin, with a lower-molecular-weight material decomposing more rapidly.
Gelatin may be sterilized by dry heat.
The bulk material should be stored in an airtight container in a cool, well-ventilated and dry place.

不和合性

Gelatin is an amphoteric material and will react with both acids and bases. It is also a protein and thus exhibits chemical properties characteristic of such materials; for example, gelatin may be hydrolyzed by most proteolytic systems to yield its amino acid components.
Gelatin will also react with aldehydes and aldehydic sugars, anionic and cationic polymers, electrolytes, metal ions, plasticizers, preservatives, strong oxidizers, and surfactants. It is precipitated by alcohols, chloroform, ether, mercury salts, and tannic acid. Gels can be liquefied by bacteria unless preserved.
Some of these interactions are exploited to favorably alter the physical properties of gelatin: for example, gelatin is mixed with a plasticizer, such as glycerin, to produce soft gelatin capsules and suppositories; gelatin is treated with formaldehyde to produce gastroresistance.

規制状況(Regulatory Status)

GRAS listed. Included in the FDA Inactive Ingredients Database (dental preparations; inhalations; injections; oral capsules, pastilles, solutions, syrups and tablets; topical and vaginal preparations). Included in medicines licensed in the UK, Europe, and Japan. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

ゼラチン,板状 上流と下流の製品情報

原材料

準備製品


ゼラチン,板状 生産企業

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9000-70-8(ゼラチン,板状)キーワード:


  • 9000-70-8
  • -Phosphoguanylyl-(3'
  • TELEOSTEAN GELATIN
  • PRIONEX(R) GELATIN
  • absorbablegelatinsponge
  • Galfoam
  • gelatinfoam
  • gelfoam
  • BLOOM 300
  • FREALAGIN(TM) AD GELATIN
  • FREALAGIN(TM) M GELATIN
  • FREALAGIN(TM) R GELATIN
  • GELATIN
  • GELATINA
  • GELATIN, FISH
  • GELATIN BOVINE TYPE A
  • GELATINE
  • gelatins
  • GELATIN TYPE A
  • GELATIN TYPE B
  • FISH GELATIN
  • Edible gelatin
  • Gelatin, granular
  • HSA Minispheres
  • PORCINEGELATIN
  • BOVINEGELATIN
  • L-γ-Glutamyl-3-carboxy-4-nitranilide
  • GELATIN POWDERED, PURE, FROM BOVINE SKIN, PH.EUR,USP
  • GELATIN POWDERED, FROM PORCINE SKIN
  • GELATINE POWDER
  • Recombinant Human Gelatin
  • ゼラチン
  • ゼルフォーム
  • ゲラチン
  • ゼルフィルム
  • スポンゼル
  • ゼラチン末
  • ゼラチン,板状
  • ゼラチン,粉末
  • ゼラチン(粉末)
  • ゼラチン, ブタ皮膚由来
  • メドジェル® シート II (PI9)
  • ゼラチン, ウシ骨由来
  • ゼラチン, LIQUID
  • メドジェル® 粒子 II (PI5)
  • メドジェル® シート II (PI5)
  • 日本薬局方 精製ゼラチン「製造専用」 ビーマトリックス® ゼラチン HG
  • 日本薬局方ゼラチン「製造専用」 ビーマトリックス® ゼラチン LS-250
  • 日本薬局方 ゼラチン(製造専用)
  • PRIONEX® 高純度 TYPE A
  • ゼラチン FROM COLD WATER FISH SKIN
  • ゼラチン FROM PORCINE SKIN
  • ゼラチン ウシ皮膚由来
  • ゼラチン 溶液
  • ゼラチン , 粉末
  • ゼラチン, liquid, Ph. Eur.
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