サリラシブ
サリラシブ 物理性質
- 融点 :
- 64-66°C
- 沸点 :
- 486.0±45.0 °C(Predicted)
- 比重(密度) :
- 1.05
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO：可溶20mg/mL、透明
- 酸解離定数(Pka):
- 3.50±0.36(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
- 安定性：:
- DMSO溶液またはエタノール溶液で-20°Cで最大3か月保存できます。
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-1858 |
サリラシブ
Salirasib |
162520-00-5 |
100mg |
￥28000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-1858 |
Salirasib
Salirasib |
162520-00-5 |
1g |
￥150000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCF102500 |
trans,trans Farnesyl Thiosalicylic Acid |
162520-00-5 |
250mg |
￥355300 |
2023-06-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1166 |
≥98% (HPLC)
Salirasib ≥98% (HPLC) |
162520-00-5 |
10mg |
￥17800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1166 |
≥98% (HPLC)
Salirasib ≥98% (HPLC) |
162520-00-5 |
50mg |
￥57200 |
2024-03-01 |
購入 |
サリラシブ 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
抗悪性腫瘍薬
説明
Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-
mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-
ras-
transformed Rat1 fibroblasts with an IC
50 value of 7.5 μM. It does not inhibit Ras farnesylation
in vitro and although FTS does inhibit prenylated protein methyltransferase (PPMTase) in cell-
free systems with a K
i value of 2.6 μM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-
fed ApoE-
deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.
化学的特性
Pale Yellow Solid
使用
Salirasib is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.
サリラシブ 上流と下流の製品情報
原材料
準備製品
サリラシブ 生産企業
Global( 119)Suppliers
162520-00-5(サリラシブ)キーワード:
- 162520-00-5
- FARNESYLTHIOSALICYLIC ACID
- FTS
- Unii-mzh0om550m
- (3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL)-2-THIOBENZOIC ACID
- 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid
- Farnesylthiosalicylate
- Salirasib
- S-Farnesylthiosalicylic acid
- (E,E)-2-[(3,7,11-TriMethyl-2,6,10-dodecatrienyl)thio]benzoic Acid
- S-trans,trans-Farnesylthiosalicylic acid
- 2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoic acid
- 2-(((2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl)thio)benzoicacid
- CS-1744
- Salirasib(S-Farnesylthiosalicylic aci)
- irasib
- Benzoic acid, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-
- Salirasib USP/EP/BP
- Salirasib (Farnesyl Thiosalicylic Acid)
- サリラシブ
- S-ファルネシルチオサリチル酸
- 2-[(3,7,11-トリメチルドデカ-2,6,10-トリエノイル)スルファニル]安息香酸
- 2-[(3,7,11-トリメチル-1-オキソ-2,6,10-ドデカトリエニル)チオ]安息香酸