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γ-シクロデキストリン

γ-シクロデキストリン 化学構造式
17465-86-0
CAS番号.
17465-86-0
化学名:
γ-シクロデキストリン
别名:
γ-シクロデキストリン;γシクロデキストリン;Schardinger γ-デキストリン;シクロオクタアミロース;Γ‐シクロデキストリン;Γ-シクロデキストリン、定量用;GAMMA シクロデキストリン
英語化学名:
Cyclooctapentylose
英語别名:
schardinger;Cavasol? W8;Cavamax? W8;CYCLOOCTAOSE;Cavamax(R) W8;CYCLOFLO(TM) 42;CYCLOOCTAAMYLOSE;CYCLOMALTOOCTAOSE;Resistant Dextrin;cyclooctapentylose
CBNumber:
CB9750405
化学式:
C48H80O40
分子量:
1297.12
MOL File:
17465-86-0.mol

γ-シクロデキストリン 物理性質

融点 :
≥300 °C
沸点 :
845.2°C (rough estimate)
比旋光度 :
[α]D25 +174~+179° (c=1, H2O) (After Drying)
比重(密度) :
1.2064 (rough estimate)
屈折率 :
1.7500 (estimate)
闪点 :
450℃
溶解性:
1 M NaOH: 25 mg/mL, may be clear to slightly hazy
外見 :
powder
色:
white
光学活性 (optical activity):
[α]/D 174.0 to 180.0°
極大吸収波長 (λmax):
λ: 420 nm Amax: ≤0.20
Merck :
14,2718
BRN :
5725162
EPAの化学物質情報:
.gamma.-Cyclodextrin(17465-86-0)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36-24/25-22
WGK Germany  2
RTECS 番号 GU2293080
3
HSコード  29400000
化審法 (8)-101 届出不要化学物質

γ-シクロデキストリン 価格 もっと(40)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQB-6145 γ-シクロデキストリン
Gamma-cyclodextrin
17465-86-0 5g ¥3600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQB-6145 γ-シクロデキストリン
Gamma-cyclodextrin
17465-86-0 25g ¥7200 2018-12-26 購入
東京化成工業 C0869 γ-シクロデキストリン >99.0%(HPLC)
γ-Cyclodextrin >99.0%(HPLC)
17465-86-0 25g ¥11700 2018-12-04 購入
東京化成工業 C0869 γ-シクロデキストリン >99.0%(HPLC)
γ-Cyclodextrin >99.0%(HPLC)
17465-86-0 5g ¥4500 2018-12-04 購入
関東化学株式会社(KANTO) 08136-50 γ‐シクロデキストリン
γ‐Cyclodextrin
17465-86-0 5g ¥3300 2018-12-13 購入

γ-シクロデキストリン MSDS


gamma-Cyclodextrin

γ-シクロデキストリン 化学特性,用途語,生産方法

外観

白色~ほとんど白色, 結晶性粉末~粉末

定義

本品は、6~8のグルコピラノースからなる環状多糖類であり、次の化学式で表される。
環状構造:6~8

溶解性

水に溶けやすく、エタノールおよびアセトンにほとんど溶けない。

用途

酵素研究用、有機物物性改良研究用、有機合成用。

化粧品の成分用途

キレート剤、吸着剤

化学的特性

White powder or crystal

化学的特性

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.

調製方法

Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.

応用例(製薬)

Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.

安全性

Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
γ-Cyclodextrin
LD50 (rat, IP): 4.6 g/kg
LD50 (rat ,IV): 4.0 g/kg
LD50 (rat, oral): 8.0 g/kg

貯蔵

Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

γ-シクロデキストリン 上流と下流の製品情報

原材料

準備製品


γ-シクロデキストリン 生産企業

Global( 220)Suppliers
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Shenzhen Sendi Biotechnology Co.Ltd.
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ATK CHEMICAL COMPANY LIMITED
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17465-86-0(γ-シクロデキストリン)キーワード:


  • 17465-86-0
  • SCHARDINGER GAMMA-DEXTRIN
  • CYCLOFLO(TM) 42
  • CYCLOOCTAOSE
  • CYCLOOCTAAMYLOSE
  • CYCLOMALTOOCTAOSE
  • GAMMA-CYCLODEXTRIN
  • Resistant Dextrin
  • cyclooctapentylose
  • gamma-Cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis
  • Sugammadex Impurity 17
  • Sugammadex Impurity 1 (Cyclooctapentylose)
  • GAMMA-CYCLODEXTRIN CELL CULTURE TESTED
  • schardinger
  • GAMMA-CYCLODEXTRIN, MIN 90%
  • Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin
  • γ-CD:Cyclooctaamylose
  • ^y-Cyclodextrin hydrate
  • Gamma Cyclodextrin (200 mg)
  • Cavamax(R) W8
  • Schardinger gamma-Dextrin Cyclooctaamylose
  • Alpha and gaMMa Cyclodextrin
  • g-Cyclodextrin hydrate
  • g-Cyclodextrin standard
  • Methyl g-cyclodextrin
  • gaMMa-Cyclodextrin >=98%
  • Cavasol? W8
  • Cavamax? W8
  • gamma-Cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany, >=90.0% cyclodextrin basis (HPLC)
  • γ-シクロデキストリン
  • γシクロデキストリン
  • Schardinger γ-デキストリン
  • シクロオクタアミロース
  • Γ‐シクロデキストリン
  • Γ-シクロデキストリン、定量用
  • GAMMA シクロデキストリン
  • オリゴサッカライド
  • シクロデキストリン
  • 機能性ホスト化合物
  • 機能性材料
  • 生化学
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