1,8-ジヒドロキシ-3-メチルアントラキノン 化学特性,用途語,生産方法
外観
うすい黄色～褐色粉末～結晶
説明
Chrysophanol is an anthraquinone that has been found in
R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 μM. Chrysophanol (5, 10, and 50 μM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E
2 (PGE
2; ) and inhibits LPS-induced DNA oxidation in BV-2 microglia.
In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; ). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
化学的特性
yellow crystalline solid or brown powder
使用
Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells 1. It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro 2.
定義
ChEBI: A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.
一般的な説明
Golden yellow plates or brown powder. Melting point 196°C. Slightly soluble in water. Pale yellow aqueous solutions turn red on addition of alkali. Solutions in concentrated sulfuric acid are red.
空気と水の反応
Insoluble in water.
反応プロフィール
Chrysophanic acid is incompatible with strong oxidizing agents.
火災危険
Flash point data for Chrysophanic acid are not available; however, Chrysophanic acid is probably combustible.
純化方法
Crystallise chrysophanic acid from EtOH or *benzene and has m 195.6-196.2o, after sublimation it in a vacuum. The yellow mono-acetate has m 188-190o (from MeOH or Me2CO). It forms Ni2+, Co2+ and Cu2+ complexes. [Beilstein 8 H 470, 8 I 725, 8 II 510, 8 III 3808, 8 IV 3277.]
1,8-ジヒドロキシ-3-メチルアントラキノン 上流と下流の製品情報
原材料
準備製品