ジメトモルフ 化学特性,用途語,生産方法
外観
白色〜ほとんど白色, 結晶性粉末〜粉末
溶解性
アセトンに溶けやすく、水にほとんど溶けない。
用途
ジメトモルフ試験用標準品。
農薬用途
殺菌剤
説明
Dimethomorph is a morpholine fungicide that inhibits fungal cell wall formation. It inhibits mycelial growth of the oomycete fungi
P. citrophthora,
P. parasitica,
P. capsici, and
P. infestans (EC
50s = 0.14, 0.38, <0.1, and 0.16-0.3 μg/ml, respectively) but is less active against the green algae species
C. vulgaris or
S. obliquus in vitro (EC
50s = 47.46 and 44.87 μg/ml, respectively). It inhibits androgen receptor (AR) activity in a reporter assay in MDA-kb2 human breast cancer cells but not in a yeast antiandrogen screen (IC
20s = 0.263 and 38.5 μM, respectively). It is not toxic to rats (LD
50 = 3,900 mg/kg) or goldfish (
C. auratus; LC
50 = >32 μg/ml).
化学的特性
Off-White Solid
使用
Dimethomorph is a systemic fungicide which exhibits protectant,
curative and antisporulant activities. It is active against fungal diseases
such as leaf blight, downy mildew, damping off and foot-rot caused by
Phytophthora spp. in/on grapes, potatoes and tomatoes.
定義
ChEBI: A mixture of (E)- and (Z)-dimethomorph in an unspecified ratio. It is used as a systemic fungicide used on vines, potatoes, and greenhouse crops; only the Z isomer has fungicidal activity.
农业用途
Fungicide: A systemic fungicide that protects crops from mold.
It also kills mold and prevents their spread; controls late
blight on tomatoes; and is used as a wood preservative to
control downey mildew.
製品名
ACROBAT® WP; FORUM DC®, [manco-
zeb + dimethomorph]; CME 151®; STATURE®
代謝経路
Limited data are available in the open literature. Information presented in
this summary is abstracted from the data evaluation published by the
Pesticide Safety Directorate (PSD, 1994). Dimethomorph is a (1:l) mixture
of the E- and Z-isomers. The Z-isomer has been shown to have all the
intrinsic biological activities. The isomerisation of the E- and Z-isomers
was observed when resolved isomers were exposed to UV light. Dimethomorph
undergoes extensive degradation and metabolism in soil,
plants and animals. The major metabolic pathway is the O-demethylation
of one of the phenolic methoxy moieties to the corresponding phenols
and conjugates. Other metabolic reactions include the oxidation of one of
the CH2 moieties of the morpholine ring and the cleavage/opening of
the morpholine ring (Scheme 1).
ジメトモルフ 上流と下流の製品情報
原材料
準備製品