テトラカイン
テトラカイン 物理性質
- 融点 :
- 41.0 to 45.0 °C
- 沸点 :
- 407.59°C (rough estimate)
- 比重(密度) :
- 1.0200 (rough estimate)
- 屈折率 :
- 1.5800 (estimate)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- soluble in Methanol
- 外見 :
- powder to crystal
- 酸解離定数(Pka):
- pKa 8.33±0.03(H2O
t = 20.0
I = 0.10 (KCl)) (Uncertain)
- 色:
- White to Almost white
- 水溶解度 :
- 156mg/L(温度表記なし)
- InChI:
- InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
- InChIKey:
- GKCBAIGFKIBETG-UHFFFAOYSA-N
- SMILES:
- C(OCCN(C)C)(=O)C1=CC=C(NCCCC)C=C1
- LogP:
- 3.510
- CAS データベース:
- 94-24-6(CAS DataBase Reference)
- NISTの化学物質情報:
- Tetracaine(94-24-6)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
 
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
| H317 |
アレルギー性皮膚反応を起こすおそれ |
感作性、皮膚 |
1 |
警告 |
 |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H351 |
発がんのおそれの疑い |
発がん性 |
2 |
警告 |
|
P201, P202, P281, P308+P313, P405,P501 |
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
|
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
T2789 |
テトラカイン >98.0%(GC)(T)
Tetracaine
>98.0%(GC)(T) |
94-24-6 |
5g |
￥5300 |
2024-03-01 |
購入 |
|
東京化成工業
|
T2789 |
テトラカイン >98.0%(GC)(T)
Tetracaine
>98.0%(GC)(T) |
94-24-6 |
25g |
￥14100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
Y0002117 |
テトラカイン European Pharmacopoeia (EP) Reference Standard
European Pharmacopoeia (EP) Reference Standard |
94-24-6 |
Y0002117 |
￥19400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
PHR3140 |
テトラカイン pharmaceutical secondary standard, certified reference material
pharmaceutical secondary standard, certified reference material |
94-24-6 |
100MG |
￥31500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1649991 |
テトラカイン United States Pharmacopeia (USP) Reference Standard
Tetracaine United States Pharmacopeia (USP) Reference Standard |
94-24-6 |
50mg |
￥59000 |
2024-03-01 |
購入 |
テトラカイン 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
表面麻酔薬
化学的特性
White or light-yellow, waxy solid. Very slightly soluble in water; soluble in
alcohol, ether, benzene, chloroform.
使用
Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.
定義
ChEBI: A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.
生物学の機能
Tetracaine hydrochloride (Pontocaine) is an ester of
PABA that is an effective topical local anesthetic agent and also is quite commonly used for spinal (subarachnoid)
anesthesia. Epinephrine is frequently added to
prolong the anesthesia.Tetracaine is considerably more
potent and more toxic than procaine and cocaine. It
has approximately a 5-minute onset and 2 to 3 hours of
action.
一般的な説明
Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.
テトラカイン 上流と下流の製品情報
原材料
準備製品
テトラカイン 生産企業
Global( 423)Suppliers
| 名前 |
電話番号 |
電子メール |
国籍 |
製品カタログ |
優位度 |
|
Wuhan Haorong Biotechnology Co.,ltd
|
+8618565342920
|
sales@chembj.net |
China |
269 |
58 |
|
Lihe Pharm Technology（Wuhan）Co.,Ltd
|
+8618071517867
|
info@lihepharma.com |
China |
194 |
58 |
|
Hebei Yanxi Chemical Co., Ltd.
|
+8617531190177
|
peter@yan-xi.com |
China |
5993 |
58 |
|
Hebei Mojin Biotechnology Co., Ltd
|
+8613288715578
|
sales@hbmojin.com |
China |
12456 |
58 |
|
Hebei Xinsheng New Material Technology Co., LTD.
|
+86-16632316109
|
xinshengkeji@xsmaterial.com |
China |
1100 |
58 |
|
Wuhan Ruichi Technology Co., Ltd
|
+8613545065237
|
admin@whrchem.com |
China |
164 |
58 |
|
Hebei Guanlang Biotechnology Co,.LTD
|
+8619930503252
|
daisy@crovellbio.com |
China |
5964 |
58 |
|
Firsky International Trade (Wuhan) Co., Ltd
|
+8615387054039
|
admin@firsky-cn.com |
China |
436 |
58 |
|
Anhui Yiao New Material Technology Co., Ltd
|
+86-199-55145978 +8619955145978
|
sales8@anhuiyiao.com |
China |
253 |
58 |
|
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.
|
+8615571922873
|
15571922873@163.com |
China |
106 |
58 |
94-24-6(テトラカイン)キーワード:
- 94-24-6
- 2-(Dimethylamino)ethyl p-(butylamino)benzoate
- 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove
- 2-dimethylaminoethylesterkyselinyp-butylaminobenzoove
- 2-dimethylaminoethylp-butylaminobenzoate
- 4-(butylamino)-benzoicaci2-(dimethylamino)ethylester
- Anetain
- Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
- Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester
- beta-Dimethylaminoethyl p-butylaminobenzoate
- Contralgin
- Diaethylaminoaethanol ester der p-butylaminobenzoesaeure
- diaethylaminoaethanolesterderp-butylaminobenzoesaeure
- Dicain
- Dikain
- Dimethylaminoethyl p-butyl-aminobenzoate
- dimethylaminoethylp-butyl-aminobenzoate
- Fissucain
- Intercain
- Landocaine
- Laudocaine
- Medihaler-tetracaine
- Meethobalm
- Metraspray
- Mucaesthin
- Niphanoid
- p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester
- p-(butylamino)-benzoicaci2-(dimethylamino)ethylester
- p-(butylamino)benzoicacid,2-(dimethylamino)ethylester
- p-butylaminobenzoyl-2-dimethylaminoethanol
- Pontocain
- ポントカイン
- ウロムカエスチン
- メジカイン
- レキソカイン
- パントカイン
- コントラルギン
- ニファノイド
- メトバルム
- テトラカイン
- アメトカイン
- フイッシュカイン
- ラウドカイン
- ムカエストヒム
- メトラスプライ
- 4-(ブチルアミノ)安息香酸2-(ジメチルアミノ)エチル
- アネタイン
- コーパロン
- インテルカイン
- ムカエスチン
- 2-(ジメチルアミノ)エチル 4-(ブチルアミノ)ベンゾアート
- アメトップ
- メジハラー-テトラカイン
- ブチロカイン
- 局所麻酔薬