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テトラカイン

テトラカイン 化学構造式
94-24-6
CAS番号.
94-24-6
化学名:
テトラカイン
别名:
ポントカイン;ウロムカエスチン;メジカイン;レキソカイン;パントカイン;コントラルギン;ニファノイド;メトバルム;テトラカイン;アメトカイン;フイッシュカイン;ラウドカイン;ムカエストヒム;メトラスプライ;4-(ブチルアミノ)安息香酸2-(ジメチルアミノ)エチル;アネタイン;コーパロン;インテルカイン
英語化学名:
Tetracaine
英語别名:
Dicain;Dikain;Anetain;Dicaine;Dlcalne;Fissucain;Intercain;Medicaine;Niphanoid;Pontocain
CBNumber:
CB9775567
化学式:
C15H24N2O2
分子量:
264.36
MOL File:
94-24-6.mol

テトラカイン 物理性質

融点 :
41.0 to 45.0 °C
沸点 :
407.59°C (rough estimate)
比重(密度) :
1.0200 (rough estimate)
屈折率 :
1.5800 (estimate)
貯蔵温度 :
2-8°C
酸解離定数(Pka):
pKa 8.33±0.03(H2O t = 20.0 I = 0.10 (KCl)) (Uncertain)
水溶解度 :
156mg/L(temperature not stated)
InChIKey:
GKCBAIGFKIBETG-UHFFFAOYSA-N
CAS データベース:
94-24-6(CAS DataBase Reference)
NISTの化学物質情報:
Tetracaine(94-24-6)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,Xi
Rフレーズ  22-40-42/43-43
Sフレーズ  22-36/37
RIDADR  UN 2811
WGK Germany  3
RTECS 番号 DG4725000
国連危険物分類  6.1
容器等級  III
HSコード  29224999
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
注意書き
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。

テトラカイン 価格 もっと(7)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 T2789 テトラカイン >98.0%(GC)(T)
Tetracaine >98.0%(GC)(T)
94-24-6 5g ¥4800 2021-03-23 購入
東京化成工業 T2789 テトラカイン >98.0%(GC)(T)
Tetracaine >98.0%(GC)(T)
94-24-6 25g ¥12800 2021-03-23 購入
Sigma-Aldrich Japan T3812 テトラカイン meets USP testing specifications
Tetracaine meets USP testing specifications
94-24-6 5g ¥18800 2021-03-23 購入
Sigma-Aldrich Japan 1649991 テトラカイン United States Pharmacopeia (USP) Reference Standard
Tetracaine United States Pharmacopeia (USP) Reference Standard
94-24-6 50mg ¥71900 2021-03-23 購入
Sigma-Aldrich Japan T7383 テトラカイン ≥98% (TLC)
Tetracaine ≥98% (TLC)
94-24-6 25g ¥35200 2021-03-23 購入

テトラカイン 化学特性,用途語,生産方法

外観

白色~ほとんど白色粉末~結晶

効能

表面麻酔薬

化学的特性

White or light-yellow, waxy solid. Very slightly soluble in water; soluble in alcohol, ether, benzene, chloroform.

使用

analgesic

使用

Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.

定義

ChEBI: A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.

生物学の機能

Tetracaine hydrochloride (Pontocaine) is an ester of PABA that is an effective topical local anesthetic agent and also is quite commonly used for spinal (subarachnoid) anesthesia. Epinephrine is frequently added to prolong the anesthesia.Tetracaine is considerably more potent and more toxic than procaine and cocaine. It has approximately a 5-minute onset and 2 to 3 hours of action.

一般的な説明

Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.

Biochem/physiol Actions

Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.

Veterinary Drugs and Treatments

Tetracaine is more irritating than proparacaine but is sometimes used in veterinary medicine. It is indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy. Tetracaine is also indicated to produce local anesthesia prior to surgical procedures in humans such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solution enters the eye through the incision.

テトラカイン 上流と下流の製品情報

原材料

準備製品


テトラカイン 生産企業

Global( 328)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
CHANGZHOU FLUORIDE CHEMICAL CO.,LTD
15995021858 15995021858
info@fluoridechem.com CHINA 107 58
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
0531-88113608 info@pharmachemm.com CHINA 200 58
Shijiazhuang Suking Biotechnology Co .,Ltd.
19955145978
19955145978 sales2@sxbiology.com CHINA 297 58
Xingtai Haoxun Import and Export Trade Co., Ltd.
+8617733977883 WhatsApp:+8617733976525
86-0319-5021664 lisa@xthaoxun.com CHINA 270 58
Wuhan Mulei New Material Technology Co. Ltd
+8619831953957
Telegram/wickr: jane8886 jane@whmulei.com;amy@whmulei.com China 993 58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
+8617731987558
xingjiu@xingjiubiotech.com China 1000 58
Hebei Crovell Biotech Co Ltd
+86-19930503285 +86-19930503285
86-0311-66562153 zoey@crovellbio.com China 3157 58
Wuhan Biocar Pharmacy Co., Ltd.
+8613669031409
+8613669031409 jason@biocar.cn China 608 58
Shanghai CRM New Material Technology Co., LTD
+8613020139835
Whatsapp:+8613020139835 Wickr me:lucyzxy lucy@shanghaicrm.com China 299 58

94-24-6(テトラカイン)キーワード:


  • 94-24-6
  • 2-(Dimethylamino)ethyl 4-(butylamino)benzoate
  • 2-(Dimethylamino)ethyl p-(butylamino)benzoate
  • 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove
  • 2-dimethylaminoethylesterkyselinyp-butylaminobenzoove
  • 2-dimethylaminoethylp-butylaminobenzoate
  • 4-(butylamino)-benzoicaci2-(dimethylamino)ethylester
  • amethocaine
  • Anetain
  • Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
  • Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester
  • beta-Dimethylaminoethyl p-butylaminobenzoate
  • Contralgin
  • Diaethylaminoaethanol ester der p-butylaminobenzoesaeure
  • diaethylaminoaethanolesterderp-butylaminobenzoesaeure
  • Dicain
  • Dicaine
  • Dikain
  • Dimethylaminoethyl p-butyl-aminobenzoate
  • dimethylaminoethylp-butyl-aminobenzoate
  • Fissucain
  • Intercain
  • Landocaine
  • Laudocaine
  • Medicaine
  • Medihaler-tetracaine
  • Meethobalm
  • Metraspray
  • Mucaesthin
  • Niphanoid
  • p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester
  • ポントカイン
  • ウロムカエスチン
  • メジカイン
  • レキソカイン
  • パントカイン
  • コントラルギン
  • ニファノイド
  • メトバルム
  • テトラカイン
  • アメトカイン
  • フイッシュカイン
  • ラウドカイン
  • ムカエストヒム
  • メトラスプライ
  • 4-(ブチルアミノ)安息香酸2-(ジメチルアミノ)エチル
  • アネタイン
  • コーパロン
  • インテルカイン
  • 局所麻酔薬
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