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こはく酸

こはく酸 化学構造式
110-15-6
CAS番号.
110-15-6
化学名:
こはく酸
别名:
こはく酸;アンバー酸;エタン-1,2-ジカルボン酸;ワームウッド酸;アスクシン;ブタン二酸;こはく酸塩;琥珀酸;こはく酸標準品;こはく酸, 99+%
英語化学名:
Succinic acid
英語别名:
SA;Asuccin;A 12084;Wormwood;NSC 25949;Katasuccin;NSC 106449;AMBER ACID;008008-93-3;Sal succini
CBNumber:
CB9852802
化学式:
C4H6O4
分子量:
118.08804
MOL File:
110-15-6.mol

こはく酸 物理性質

融点 :
185 °C
沸点 :
235 °C
比重(密度) :
1.19 g/mL at 25 °C(lit.)
屈折率 :
n20/D 1.4002(lit.)
FEMA :
4719 | SUCCINIC ACID
闪点 :
>230 °F
貯蔵温度 :
Store at RT.
溶解性:
Soluble in ethanol, ethyl ether, acetone and methanol. Insoluble in toluene, benzene, carbon disulfide, carbon tetrachloride and petroleum ether.
酸解離定数(Pka):
4.16(at 25℃)
外見 :
Powder/Solid
色:
White to off-white
PH:
2.7 (10g/l, H2O, 20℃)
水溶解度 :
80 g/L (20 ºC)
Merck :
14,8869
BRN :
1754069
安定性::
Stable. Substances to be avoided include strong bases, strong oxidizing agents. Combustible.
InChIKey:
KDYFGRWQOYBRFD-UHFFFAOYSA-N
CAS データベース:
110-15-6(CAS DataBase Reference)
NISTの化学物質情報:
Butanedioic acid(110-15-6)
EPAの化学物質情報:
Butanedioic acid(110-15-6)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  37/38-41-36/37/38
Sフレーズ  26-36/37/39-37/39-39
RIDADR  UN 3265 8/PG 3
WGK Germany  1
RTECS 番号 WM4900000
自然発火温度 470 °C
TSCA  Yes
HSコード  29171990
有毒物質データの 110-15-6(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 2260 mg/kg
化審法 (2)-846 届出不要化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H303 飲み込むと有害のおそれ 急性毒性、経口 5 P312
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

こはく酸 価格 もっと(64)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA12084 こはく酸, 99+%
Succinic acid, 99+%
110-15-6 500g ¥8410 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01AFAA12084 こはく酸, 99+%
Succinic acid, 99+%
110-15-6 2500g ¥35140 2018-12-26 購入
東京化成工業 S0100 こはく酸 >99.0%(T)
Succinic Acid >99.0%(T)
110-15-6 500g ¥2900 2018-12-04 購入
東京化成工業 S0100 こはく酸 >99.0%(T)
Succinic Acid >99.0%(T)
110-15-6 25g ¥1600 2018-12-04 購入
関東化学株式会社(KANTO) 37363-01 こはく酸 >99.3%(T)
Succinic acid >99.3%(T)
110-15-6 500g ¥2400 2018-12-13 購入

こはく酸 MSDS


1,2-Ethanedicarboxylic acid

こはく酸 化学特性,用途語,生産方法

外観

白色, 結晶~結晶性粉末

定義

本品は、次の化学式で表されるジカルボン酸である。

溶解性

水, エタノールに可溶。熱水に極めて溶けやすく、水、エタノールにやや溶けやすく、ジエチルエーテルにやや溶けにくい。エタノール、メタノール、アセトン、熱水、熱ギ酸に可溶、エーテルに難溶。

用途

合成清酒、味噌、しょう油

化粧品の成分用途

pH調整剤、香料

化学的特性

Succinic acid,C02H(CH2)2C02H, also known as butanedioic acid,butane diacid, and amber acid, is a colorless odorless prisms or white crystalline powder that melts at 185°C (364 of). Soluble in water and alcohol, it is used as a chemical intermediate, Succinic acid is used in lacquers,medicine,dyes,and as a taste modifier.

使用

succinic acid is widely use as organic intermediates for the pharmaceutical, engineering plastics, resins etc.. For the synthesis of sedatives, contraceptives and cancer drugs in the pharmaceutical industry. In the chemical industry for the production of dyes, alkyd resin, glass fiber reinforced plastics, ion exchange resins and pesticides.

使用

Succinic Acid is an acidulant that is commercially prepared by the hydrogenation of maleic or fumaric acid. it is a nonhygroscopic acid but is more soluble in 25°c water than fumaric and adipic acid. it has low acid strength and slow taste build-up; it is not a substitute for normal acidulants. it combines with proteins in modifying the plasticity of bread dough. it functions as an acidulant and flavor enhancer in relishes, beverages, and hot sausages.

定義

A crystalline carboxylic acid, HOOC(CH2)2COOH, that occurs in amber and certain plants. It forms during the fermentation of sugar (sucrose).

定義

ChEBI: An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.

Biotechnological Production

Traditionally, succinic acid is produced by petrochemical synthesis using the precursor maleic acid. However, there are some microorganisms that are able to produce succinic acid (e.g. Actinobacillus succinogenes, Anaerobiospirillum succiniciproducens and Mannheimia succiniciproducens). Maximum product concentrations of 106 g.L-1 with a yield of 1.25 mol of succinic acid per mole of glucose and a productivity of 1.36 g.L-1.h-1 have been achieved by growing A. succinogenes on glucose . A high productivity of 10.40 g.L-1.h-1 has been reached with A. succinogenes growing on a complex medium with glucose in a continuous process with an integrated membrane bioreactor-electrodialysis process. In this process, the product concentration has been 83 g.L-1 . Moreover, metabolic engineering methods were used to develop strains (e.g. C. glutamicum, E. coli, S. cervisiae and Y. lipolytica) with high productivity and titer as well as low byproduct formation. For example, growing C. glutamicum strain DldhA-pCRA717 on a defined medium with glucose, a high productivity of 11.80 g.L-1.h-1 with a yield of 1.37 mol of succinic acid per mole of glucose and a titer of 83 g.L-1 has been reported after 7 h. An extended cultivation resulted in a product concentration of 146 g.L-1 after 46 h.

一般的な説明

White crystals or shiny white odorless crystalline powder. pH of 0.1 molar solution: 2.7. Very acid taste.

空気と水の反応

Slightly water soluble.

反応プロフィール

Succinic acid reacts exothermically to neutralize bases, both organic and inorganic. Can react with active metals to form gaseous hydrogen and a metal salt. Such reactions are slow in the dry, but systems may absorb water from the air to allow corrosion of iron, steel, and aluminum parts and containers. Reacts slowly with cyanide salts to generate gaseous hydrogen cyanide. Reacts with solutions of cyanides to cause the release of gaseous hydrogen cyanide. May generate flammable and/or toxic gases and heat with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. May react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Can be oxidized exothermically by strong oxidizing agents and reduced by strong reducing agents. May initiate polymerization reactions.

火災危険

Flash point data for Succinic acid are not available. Succinic acid is probably combustible.

生物学的応用

Succinic acid and its derivatives are used as flavoring agents for food and beverages. This acid could be used as feedstock for dyes, insecticides, perfumes, lacquers, as well as in the manufacture of clothing, paint, links, and fibers (McKinlay et al. 2007). Succinic acid is widely used in medicine as an antistress, antihypoxic, and immunity-improving agent, in animal diets, and as a stimulator of plant growth. It is also a component of bio-based polymers such as nylons or polyesters (Kamzolova et al. 2012b). Succinate esters are precursors for the known petrochemical products such as 1,4-butanediol, tetrahydrofuran, c-butyrolactone, and various pyrrolidinone derivatives (Bechthold et al. 2008).
Succinic acid production by Y. lipolytica was reported for the first time when it was grown on ethanol under aerobic conditions and nitrogen limitation. Succinic acid amount was 63.4 g/L as the major product of batch fermentation in this process. However, the disadvantage was low yield of succinic acid on ethanol (58 %), and a high cost of production (Kamzolova et al. 2009).
Kamzolova et al. developed a novel process for the production of succinic acid. It includes the synthesis of a-ketoglutaric acid by a thiamine-auxotrophic strain Y. lipolytica VKMY-2412 from n-alkanes, and subsequent oxidation of the acid by hydrogen peroxide to succinic acid. The concentration of succinic acid and its yield were found to be 38.8 g/L and 82.45 % of n-alkane consumed, respectively (Kamzolova et al. 2012b).
Succinic acid production was also studied by genetically modified strains using glucose and glycerol as substrates. Yuzbashev et al. constructed temperaturesensitive mutant strains with mutations in the succinate dehydrogenase encoding gene SDH1 by in vitro mutagenesis-based approach. Then, the mutants were used to optimize the composition of the media for selection of transformants with the deletion in the SDH2 gene. The defects of each succinate dehydrogenase subunit prevented the growth on glucose, but the mutant strains grew on glycerol and produced succinate in the presence of the buffering agent CaCO3. Subsequent selection of the strain with deleted SDH2 gene for increased viability was allowed to obtain a strain that is capable to accumulate succinate at the level of more than 450 g/L with buffering and more than 17 g/L without buffering. Therefore, a reduced succinate dehydrogenase activity can lead to an increased succinate production (Yuzbashev et al. 2010). Y. lipolytica is able to produce succinic acid at low pH values. High amounts of succinate can be achieved by genetic engineering (Otto et al. 2013).

安全性プロファイル

Moderately toxic by subcutaneous route. A severe eye irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

純化方法

Wash it with diethyl ether. Crystallise it from acetone, distilled water, or tert-butanol. Dry it under vacuum over P2O5 or conc H2SO4. Also purify it by conversion to the disodium salt which, after crystallisation from boiling water (charcoal), is treated with mineral acid to regenerate the succinic acid. The acid is then recrystallised and dried in a vacuum. [Beilstein 2 H 606, 2 IV 1908.]

こはく酸 上流と下流の製品情報

原材料

準備製品


こはく酸 生産企業

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110-15-6(こはく酸)キーワード:


  • 110-15-6
  • SUCCINIC ACID, REAGENT (ACS)SUCCINIC ACID, REAGENT (ACS)SUCCINIC ACID, REAGENT (ACS)SUCCINIC ACID, REAGENT (ACS)
  • SUCCINIC ACID GRAN
  • Aspartic Acid Impurity 8
  • Succinic acid Manufacturer
  • Acid of amber
  • Asuccin
  • Bernsteinsaure
  • Butanediacid
  • Ethane-1,2-dicarboxylicacid
  • Ethanedicarboxylic acid
  • Ethylene succinic acid
  • ethylenedicarboxylicacid
  • SUCCINIC ACID REAGENT (ACS)
  • SUCCINICACID,CRYSTAL,REAGENT,ACS
  • SUCCINICACID,ULTRAPURE
  • succinylic acid
  • BERNSTEINSAEURE
  • Bernsteinsure
  • 3-[(4aR,8aR)-2-(cyclopropylmethyl)-1,3,4,5,6,7,8,8a-octahydroisoquinolin-4a-yl]phenol
  • Succinic acid, ACS, 99.0% min
  • SUCCINIC ACID FCC, KOSHER
  • SUCCINIC ACID, N.F. GRADE
  • SUCCINIC ACID, NATURAL
  • SUCCINIC ACID, TECHNICAL GRADE
  • SUCCINIC ACID extrapure AR
  • Succinic Acid, Crystal, Reagent
  • (6R)-6-methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide
  • Succinic acid,Amber acid,Butanedioic acid,Succinate
  • Butanedioic acid
  • succinic acid(amber acid)
  • こはく酸
  • アンバー酸
  • エタン-1,2-ジカルボン酸
  • ワームウッド酸
  • アスクシン
  • ブタン二酸
  • こはく酸塩
  • 琥珀酸
  • こはく酸標準品
  • こはく酸, 99+%
  • 構造分類
  • 官能性 & α,ω-二官能性アルカン
  • α,ω-アルカンジカルボン酸
  • α,ω-二官能性アルカン
  • 代謝産物
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