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4-アミノピリジン

4-アミノピリジン 化学構造式
504-24-5
CAS番号.
504-24-5
化学名:
4-アミノピリジン
别名:
4-アミノピリジン;ピリジン-4-アミン;4-ピリジンアミン;アビトロール100;アビトロール;4アミノピリジン;4-アミノピリジン標準品;4-アミノピリジン(γ-〃);4-ピリジルアミン;4‐アミノピリジン;4‐アミノピリジン (4= Γ);4‐アミノピリジン標準品;ダルファムプリジン;ファンプリジン;ファムプリジン;ファンプリジン (JAN)
英語化学名:
4-Aminopyridine
英語别名:
4APY;4-AP;mi-w-3;AMpyra;EL 970;avitrol;vmi10-3;Neurelan;Prc 1237;VMI 10-3
CBNumber:
CB9853687
化学式:
C5H6N2
分子量:
94.11
MOL File:
504-24-5.mol

4-アミノピリジン 物理性質

融点 :
157 °C
沸点 :
273 °C(lit.)
比重(密度) :
1.26
屈折率 :
1.5560 (estimate)
闪点 :
156°C
貯蔵温度 :
0-6°C
溶解性:
H2O: soluble50mg/mL, clear, colorless
酸解離定数(Pka):
9.114(at 25℃)
外見 :
Crystalline Powder, Solid or Crystals
色:
White to faint grey to light yellow
水溶解度 :
Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck :
14,3933
BRN :
105782
InChIKey:
NUKYPUAOHBNCPY-UHFFFAOYSA-N
CAS データベース:
504-24-5(CAS DataBase Reference)
NISTの化学物質情報:
4-Pyridinamine(504-24-5)
EPAの化学物質情報:
4-Pyridinamine(504-24-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T+,N,T,Xi
Rフレーズ  28-36/37/38-51/53-23/24/25
Sフレーズ  26-36/37/39-45-60-61-37/39-28A-1
RIDADR  UN 2671 6.1/PG 2
WGK Germany  3
RTECS 番号 US1750000
8-21
自然発火温度 640 °C
Hazard Note  Toxic/Irritant
TSCA  Yes
国連危険物分類  6.1
容器等級  II
HSコード  29333999
有毒物質データの 504-24-5(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: 21 mg/kg
化審法 (5)-724
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H300 飲み込むと生命に危険 急性毒性、経口 1, 2 危険 P264, P270, P301+P310, P321, P330,P405, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
H401 水生生物に毒性 水生環境有害性、急性毒性 2 P273, P501
H411 長期的影響により水生生物に毒性 水生環境有害性、慢性毒性 2
注意書き
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P307+P311 暴露した場合:医師に連絡すること。

4-アミノピリジン 価格 もっと(37)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-407N 4-アミノピリジン
4-Aminopyridine
504-24-5 10mg ¥4400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-407NB-250 4-アミノピリジン
4-Aminopyridine
504-24-5 250mg ¥14700 2018-12-26 購入
東京化成工業 A0414 4-アミノピリジン >99.0%(GC)(T)
4-Aminopyridine >99.0%(GC)(T)
504-24-5 100g ¥13400 2018-12-04 購入
東京化成工業 A0414 4-アミノピリジン >99.0%(GC)(T)
4-Aminopyridine >99.0%(GC)(T)
504-24-5 25g ¥4200 2018-12-04 購入
関東化学株式会社(KANTO) 01258-50 4‐アミノピリジン >98.0%(T)
4‐Aminopyridine (4=γ) >98.0%(T)
504-24-5 5g ¥2800 2018-12-13 購入

4-アミノピリジン MSDS


4-Aminopyridine

4-アミノピリジン 化学特性,用途語,生産方法

外観

白色~赤褐色, 結晶~結晶性粉末

溶解性

水に易溶, エタノール, エーテルに可溶。水、エタノール及びアセトンに溶けやすい。

用途

有機合成原料(医薬、農薬)。

用途

鳥よけ、駆除剤の中間体

効能

けいれん誘発薬, カリウムチャネル遮断薬

説明

Dalfampridine (also referred to as 4-AP) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.
From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.

化学的特性

4-Aminopyridine is white to tan or brown crystalline material. Odorless.

化学的特性

WHITE TO SLIGHTLY YELLOW FINE CRYSTALLINE POWDER

化学的特性

4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.

Originator

Rush University Medical Center (United States)

使用

vasodilator

使用

Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.

定義

ChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.

brand name

Neurelan (E′lan);Ampyra.

一般的な説明

White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.

反応プロフィール

4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

健康ハザード

Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.

健康ハザード

4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks

火災危険

Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.

安全性プロファイル

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.

職業ばく露

Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison

輸送方法

UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

純化方法

Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]

不和合性

Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.

廃棄物の処理

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.

4-アミノピリジン 上流と下流の製品情報

原材料

準備製品


4-アミノピリジン 生産企業

Global( 390)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hangzhou Cyanochem Co., Ltd.
+86 17788583750
+86 571 85220831 sales@cyanochem.com CHINA 284 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21707 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135
sales@nbinno.com CHINA 925 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58

504-24-5(4-アミノピリジン)キーワード:


  • 504-24-5
  • 4-amino-pyridin
  • Avitrol 200
  • avitrol200
  • Compound 1861
  • Frampridine
  • mi-w-3
  • 4-AP
  • 4APY
  • 4-pyridinamine
  • 4-PYRIDYLAMINE
  • Amino-4-pyridine
  • AMINOPYRIDINE, 4-
  • AKOS 91150
  • FAMPRIDINE
  • GAMMA-AMINOPYRIDINE
  • GAMMA-PYRIDYLAMINE
  • avitrol
  • AVITROL(R)
  • AURORA KA-676
  • TIMTEC-BB SBB004393
  • γ-Pyridylamine
  • PYRIDIN-4-YLAMINE
  • PYRIDIN-4-AMINE
  • P-AMINO PYRIDINE
  • 4-Aminopyridine;4-AP; Pyridin-4-amine
  • 4-PyridinylaMine
  • AMpyra
  • DalfaMpridine
  • EL 970
  • Neurelan
  • 4-アミノピリジン
  • ピリジン-4-アミン
  • 4-ピリジンアミン
  • アビトロール100
  • アビトロール
  • 4アミノピリジン
  • 4-アミノピリジン標準品
  • 4-アミノピリジン(γ-〃)
  • 4-ピリジルアミン
  • 4‐アミノピリジン
  • 4‐アミノピリジン (4= Γ)
  • 4‐アミノピリジン標準品
  • ダルファムプリジン
  • ファンプリジン
  • ファムプリジン
  • ファンプリジン (JAN)
  • カリウムチャンネル遮断薬
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