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プロピレンオキシド

プロピレンオキシド 化学構造式
75-56-9
CAS番号.
75-56-9
化学名:
プロピレンオキシド
别名:
プロピレンオキシド;2-メチルオキシラン;1,2-エポキシプロパン;酸化プロピレン;メチルオキシラン;プロピレンオキサイド;プロピレンオキシド標準品;1,2-エポキシプロパン (別名 酸化プロピレン);1,2-エポキシプロパン(別名酸化プロピレン);酸化プロピレン (1,2-エポキシプロパン);プロピレンオキシド(酸化プロピレン);1,2-エポキシプロパン(PO);(±)-酸化プロピレン;酸化プロピレン, research grade;1,2-プロピレンオキシド;酸化プロピレン (JAN)
英語化学名:
Propylene oxide
英語别名:
PO;Epihydrin;ai3-07541;ene oxide;NCI-C50099;epoxy-propan;Epoxypropane;PROPYLENOXIDE;methyl-oxiran;caswellno713a
CBNumber:
CB9854235
化学式:
C3H6O
分子量:
58.08
MOL File:
75-56-9.mol

プロピレンオキシド 物理性質

融点 :
-112 °C
沸点 :
34 °C(lit.)
比重(密度) :
0.83 g/mL at 25 °C(lit.)
蒸気密度:
2 (vs air)
蒸気圧:
29.43 psi ( 55 °C)
屈折率 :
n20/D 1.366(lit.)
闪点 :
−35 °F
貯蔵温度 :
2-8°C
溶解性:
425-450g/l
外見 :
Liquid
色:
Clear
臭い (Odor):
Ethereal; characteristic; sweet, alcoholyc; like natural gas.
爆発限界(explosive limit):
1.9-36%(V)
水溶解度 :
40 g/100 mL (20 ºC)
凝固点 :
-112.13℃
Merck :
14,7856
BRN :
79763
Henry's Law Constant:
Not an environmentally important parameter because propylene oxide reacts rapidly with water
暴露限界値:
TLV-TWA 50 mg/m3 (20 ppm) (ACGIH), 240 mg/m3 (100 ppm) (OSHA); IDLH 2000 ppm.
安定性::
Stable. Incompatible with acids, bases, oxidizing agents, copper, copper alloys, brass, bronze, iron, metal chlorides, peroxides and a wide variety of other materials. Reacts with compounds containing labile hydrogen. Extremely flammable - note low boiling point, low flash point and very wide explosion limits. Moisture sensitive.
CAS データベース:
75-56-9(CAS DataBase Reference)
NISTの化学物質情報:
Propylene oxide(75-56-9)
IARC:
2B (Vol. Sup 7, 60) 1994
EPAの化学物質情報:
Propylene oxide (75-56-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F+,T
Rフレーズ  45-46-12-20/21/22-36/37/38
Sフレーズ  53-45
RIDADR  UN 1280 3/PG 1
WGK Germany  3
RTECS 番号 TZ2975000
自然発火温度 430 °C
TSCA  Yes
HSコード  2910 20 00
国連危険物分類  3
容器等級  I
有毒物質データの 75-56-9(Hazardous Substances Data)
毒性 LD50 orally in rats: 1.14 g/kg (Smyth)
消防法 危険物第4類特殊引火物
化審法 (2)-219
安衛法 特化則 特定化学物質(特定第2類) 変異原性物質
PRTR法 第一種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H224 極めて引火性の高い液体および蒸気 引火性液体 1 危険
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H340 遺伝性疾患のおそれ 生殖細胞変異原性 1A, 1B 危険
H350 発がんのおそれ 発がん性 1A, 1B 危険
注意書き
P201 使用前に取扱説明書を入手すること。
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P370+P378 火災の場合:消火に...を使用すること。
P403+P235 換気の良い場所で保管すること。涼しいところに 置くこと。
P405 施錠して保管すること。

プロピレンオキシド 価格 もっと(35)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01POS00236
Propylene Oxide, EM Grade
75-56-9 1pint ¥12800 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01SEV33715 酸化プロピレン
Propylene oxide
75-56-9 500mL ¥2950 2020-09-21 購入
東京化成工業 E0016 プロピレンオキシド >99.0%(GC)
Propylene Oxide >99.0%(GC)
75-56-9 25mL ¥1700 2021-03-23 購入
東京化成工業 E0016 プロピレンオキシド >99.0%(GC)
Propylene Oxide >99.0%(GC)
75-56-9 500mL ¥2900 2021-03-23 購入
関東化学株式会社(KANTO) 22016-1A プロピレンオキシド(酸化プロピレン)
(±)‐Propylene oxide
75-56-9 1L ¥6000 2021-03-23 購入

プロピレンオキシド 化学特性,用途語,生産方法

外観

無色澄明の液体

溶解性

エタノール及びアセトンに極めて溶けやすく、水に溶ける。

解説

1,2-epoxypropane.C3H6O(58.08).酸化プロピレン,メチルオキシラン(methyloxirane)ともいう."実験室的には,2-クロロプロパノールをアルカリで処理すると得られる.工業的には,従来よりプロペンと次亜塩素酸との反応で得られるプロピレンクロロヒドリンの脱塩化水素によって製造されている.近年では,プロペンを各種ヒドロペルオキシドにより酸化する方法(ハルコン法)が開発されている.ハルコン法でエチルベンゼンヒドロペルオキシドを用いると,プロピレンオキシドとメチルベンジルアルコールが生成し,後者を酸触媒を用いて脱水するとスチレンが併産される.ほかにtert-ブチルペルオキシドを用い,イソブテンを併産する方法がある.最近,チタノシリケートを触媒に用い,液相で過酸化水素によりプロペンを酸化する直接酸化法が工業化されている.光学異性体をもつ.エーテル臭を有する引火性の無色の液体.融点-112 ℃,沸点33.9 ℃.d2525 0.826.n25D 1.363.水および有機溶剤に可溶.溶解力がとくにすぐれており,合成および天然の樹脂,各種有機物質の低沸点溶剤に用いられる.また,プロパンジオールをはじめ,界面活性剤,合成樹脂,溶剤などの合成原料となる.有毒.[CAS 75-56-9]
森北出版「化学辞典(第2版)

用途

中間体、殺菌剤

用途

プロピレングリコール、プロピレングリコールエーテルの原料 (ULLMANNS(E) (6TH, 2003)) ポリウレタン用ポリエーテル、潤滑油、界面活性剤、油水分離剤 (HSDB (2010))

効能

製剤補助

農薬用途

燻蒸剤

説明

Propylene oxide is an allergic and irritant agent, used as a solvent and raw material in the chemical industry as starting material and intermediate for a broad spectrum of polymers.

化学的特性

Propylene oxide is soluble in water and miscible with most organic solvents. It is found to be an excellent low-boiling solvent for cellulose acetate, nitrocellulose, adhesive compositions and vinyl chloride-acetate resins. It is also a solvent for hydrocarbons, gums and shellac. Some of its uses are as a solvent and stabilizer in DDT aerosol-type insecticides, and as a fumigant and food preservative. Since it is an acid acceptor, it is also used as a stabilizer for vinyl chloride resins and other chlorinated systems.

物理的性質

Propylene oxide is a colorless liquid with an agreeable, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were 24 mg/m3 (10 ppmv) and 84 μg/m3 (35 ppmv), respectively (Hellman and Small, 1974).

使用

Propylene oxide is used as a fumigant forfoodstuffs; as a stabilizer for fuels, heat-ing oils, and chlorinated hydrocarbons; asa fuel–air explosive in munitions; and toenhance the decay resistance of wood andparticleboard (Mallari et al. 1989). Recentstudies indicate that the fumigant potentialof propylene oxide enhances at a low pres-sure of 100 mm Hg which could render it asan alternative to methyl bromide for rapiddisinfection of commodities (Isikber et al.2004).

使用

It can be used as a dehydrating agent for the preparation of slides in electron microscopy. Occupational dermatitis was also reported while using a skin disinfectant swab.

使用

Chemical intermediate in preparation of polyethers to form polyurethanes; in preparation of urethane polyols and propylene and dipropylene glycols; in preparation of lubricants, surfactants, oil demulsifiers. As solvent; fumigant; soil sterilant.

定義

ChEBI: An epoxide that is oxirane substituted by a methyl group at position 2.

調製方法

Propylene oxide is synthesized commercially from propylene through the intermediate propylene chlorohydrin. It also can be made by peroxidation of propylene using alkylhydroperoxides, but this method produces coproducts as well, often styrene or cumene. Propylene oxide is also synthesized via oxidation of propylene with hydrogen peroxide, which produceswater as the only coproduct.

一般的な説明

A clear colorless volatile liquid with an ethereal odor. Flash point -35°F. Boiling point 95°F. Density 6.9 lb./gal. Flammable over a wide range of vapor-air concentrations. If contaminated, may polymerize with evolution of heat and possible rupture of container. Vapors irritate eyes, skin, and respiratory system. Prolonged contact with skin may result in delayed burns. Vapors heavier than air. Used as a fumigant, in making detergents and lubricants, and to make other chemicals.

空気と水の反応

Highly flammable. Soluble in water.

反応プロフィール

1,3-Propylene oxide react with oxidizing agents and strong acids . Reacts with Grignard reagents and organolithium compounds. An explosion occurred when Propylene oxide was added to an epoxy resin. Propylene oxide was concluded that polymerization was catalyzed by an amine accelerator in the resin [Bretherick, 5th Ed., 1995]. Underwent polymerization when mixed with sodium hydroxide causing ignition and explosion of a drum of the crude product. [Combust Sci. Technol., 1983].

危険性

Highly flammable, dangerous fire risk, explosive limits in air 2–22%. An irritant. TLV: 20 ppm; animal carcinogen.

健康ハザード

Exposure to propylene oxide vapors cancause moderate to severe irritation of the eyes, mucous membranes, and skin. Inhala-tion can also produce weakness and drowsi-ness. Symptoms of acute exposure in testanimals were lachrymation, salivation, gasp-ing, and labored breathing and dischargefrom nose. Harris et al. (1989) in a studyon Fischer-344 female rats found no adverseeffect below a 300-ppm exposure level.However, at the chronic inhalation levelof 500 ppm the gain in the maternal bodyweight and food consumption were reducedsignificantly. In a similar chronic inhalationstudy on Wistar rats, Kuper et al. (1988)observed a decrease in the body weight anddegenerative and hyperplastic change in thenasal mucosa when rats were exposed to300 ppm of propylene oxide. The investiga-tors have reported an increase in the inci-dence of malignant tumors in the mammaryglands and other sites in female rats.
Contact with its dilute aqueous solutionscan produce edema, blistering, and burns onthe skin. It is mutagenic in the Ames test anda suspected animal carcinogen. Its carcino-genicity in humans is not established. Omuraet al. (1994) reported dose-dependent testicu-lar toxicity of this compound in rats inducedfrom repeated intraperitoneal injections. Itsodor threshold is 200 ppm.

火災危険

Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. Vapors form explosive mixture with air. If polymerization takes place in container, there may be a violent rupture of container. Explosion hazard is severe when exposed to flame. Violently reacts with acetylide- forming metals such as copper or copper alloys, ammonium hydroxide; chlorosulfonic acid; hydrochloric acid; hydrofluoric acid; nitric acid; oleum and sulfuric acid. Hazardous polymerization may occur. Avoid active catalytic surfaces such as anhydrous chlorides of iron, tin, and aluminum; peroxides of iron and aluminum; and alkali metal hydroxides, high temperatures; alkalies; aqueous acids; amines and acidic alcohols.

化学反応性

Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Polymerization can occur when this product is exposed to high temperatures or is contaminated with alkalies, aqueous acids, amines, and acidic alcohols; Inhibitor of Polymerization: Not pertinent.

工業用途

Propylene oxide finds its largest use as chemical intermediates. It reacts readily with dilute amounts of mineral acids (e.g., hydrochloric acid) to form the chlorohydrin addition product. This reactivity with acid makes this epoxy solvent valuable acid acceptor-type stabilizers for several chlorinated solvents. Trace amounts of hydrogen chloride from chlorinated solvent degradation are immediately neutralized by reaction with the propylene oxide stabilizer. Reaction of propylene oxide with an alcohol or phenol in the presence of an acid catalyst yields the monoether of propylene glycol.

接触アレルゲン

Propylene oxide is an allergic and irritant agent, used as a solvent and raw material in the chemical industry, as the starting material and intermediate for a broad spectrum of polymers. It can be used as a dehydrating agent for the preparation of slides in electron microscopy. Occupational dermatitis was also reported following the use of a skin disinfectant swab.

安全性プロファイル

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and skin contact. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A severe skin and eye irritant. Flammable liquid. A very dangerous fire and explosion hazard when exposed to heat or flame. Explosive reaction with epoxy resin and sodium hydroxide. Forms explosive mixtures with oxygen. Reacts with ethylene oxide + polyhydric alcohol to form the thermally unstable polyether alcohol. Incompatible with NH4OH, chlorosulfonic acid, HCl, HF, HNO3, oleum, H2SO4. Dangerous; can react vigorously with oxidizing materials. Keep away from heat and open flame. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.

職業ばく露

Propylene oxide is used as an interme- diate in the production of polyether polyols and propylene glycol; as a fumigant; in the production of adducts as ure- thane foam ingredients; in detergent manufacture; as a component in brake fluids.

Carcinogenicity

Propylene oxide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

環境運命予測

Biological. Bridié et al. (1979) reported BOD and COD values of 0.17 and 1.77 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a 5 d period. When a sewage seed was used in a separate screening test, a BOD value of 0.20 g/g was obtained. The ThOD for propylene oxide is 2.21 g/g.
Photolytic. Anticipated products from the reaction of propylene oxide with ozone or OH radicals in the atmosphere are formaldehyde, pyruvic acid, CH3C(O)OCHO, and HC(O)OCHO (Cupitt, 1980). An experimentally determined reaction rate constant of 5.2 x 10-13 cm3/molecule?sec was reported for the gas phase reaction of propylene oxide with OH radicals (Güsten et al., 1981).
Chemical/Physical. The reported hydrolysis half-life for the conversion of propylene oxide to 1,2-propanediol in water at 25 °C and pH 7 is 14.6 d (Mabey and Mill, 1978). The second-order hydrolysis rate constant of propylene oxide in 3.98 mM perchloric acid and 36.3 °C is 0.124/M?sec (Kirkovsky et al., 1998).
May polymerize at high temperatures or on contact with alkalies, aqueous acids, amines, and acid alcohols (NIOSH, 1997).
At an influent concentration of 1.0 g/L, treatment with GAC resulted in an effluent concentration of 739 mg/L. The adsorbability of the GAC used was 52 mg/g carbon (Guisti et al., 1974).

貯蔵

Propylene oxide is stored in a flammableliquid cabinet isolated from combustible andoxidizable materials. It is shipped in glassbottles and metal containers under a nitrogenatmosphere.

輸送方法

UN1280 Propylene oxide, Hazard Class: 3; Labels: 3-Flammable liquid

純化方法

Dry the oxide with Na2SO4 or CaH2 and fractionally distil it through a packed column (glass helices), after refluxing with Na, CaH2, or KOH pellets. [Beilstein 17 I 4, 17 II 131, 17 III/IV 17, 17/1 V 17.] The R(+)enantiomer [15448-47-2] and the S(-)enantiomer [16088-62-3] have b 33-34o/atm and [] 20 ±14.6o (neat). [Beilstein 17/1 V 17.]

Toxicity evaluation

The toxic effects of propylene oxide are related to its ability to react directly, without metabolic activation, with cellular macromolecules, nucleophilic sites, and nonprotein sulfhydryls. Therefore, it reacts with various components of cells, including DNA, RNA, and proteins.

不和合性

Vapors may form explosive mixture with air. Reacts with strong oxidizers, anhydrous metal chlor- ides; chlorine, iron, strong acids; caustics and peroxides. Polymerization may occur due to high temperatures or con- tamination with alkalis, aqueous acids; amines, metal chlor- ides; and acidic alcohols. Attacks some plastics, coatings and rubber.

廃棄物の処理

Concentrated waste contain- ing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides- perforation of a container of the waste from a safe distance followed by open burning

プロピレンオキシド 上流と下流の製品情報

原材料

準備製品


プロピレンオキシド 生産企業

Global( 301)Suppliers
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75-56-9(プロピレンオキシド)キーワード:


  • 75-56-9
  • Propylene oxide, extra pure, 99.5%
  • Propylene oxide, pure, 99%
  • PROPYLENEOXIDE,REAGENT
  • 1,2-Epoxypropane(Propylene oxide)
  • PROPYLENOXIDE
  • propylene oxide 1,2-epoxypropane methyloxirane
  • (±)-Methyloxirane, 1,2-Epoxypropane
  • Propylene oxide, 99%, pure
  • Propylene oxide, 99.5%, extra pure
  • Propylene oxide, extra pure
  • PROPYLENE OXIDE REAGENT PLUS 99% &
  • PROPYLENE OXIDE, 500MG, NEAT
  • PROPYLENE OXIDE REAGENTPLUS(TM) 99%
  • PROPYLENE OXIDE, REAGENTPLUS, 99%
  • 1,2-EPOXYPROPANE 99+%
  • PropyleneOxide-TechnicalGrade
  • PropyleneOxide,Certified
  • Epihydrin
  • epoxy-propan
  • Epoxypropane
  • Ethylene oxide, methyl-
  • Methylethylene oxide
  • methyl-ethyleneoxid
  • methylethyleneoxide
  • methyloxacyclopropane
  • methyl-oxiran
  • NCI-C50099
  • Oxirane, methyl-
  • oxirane,methyl
  • oxirane,methyl-
  • プロピレンオキシド
  • 2-メチルオキシラン
  • 1,2-エポキシプロパン
  • 酸化プロピレン
  • メチルオキシラン
  • プロピレンオキサイド
  • プロピレンオキシド標準品
  • 1,2-エポキシプロパン (別名 酸化プロピレン)
  • 1,2-エポキシプロパン(別名酸化プロピレン)
  • 酸化プロピレン (1,2-エポキシプロパン)
  • プロピレンオキシド(酸化プロピレン)
  • 1,2-エポキシプロパン(PO)
  • (±)-酸化プロピレン
  • 酸化プロピレン, research grade
  • 1,2-プロピレンオキシド
  • 酸化プロピレン (JAN)
  • 構造分類
  • 三員環化合物
  • オキシラン
  • 殺虫剤
  • 燻蒸剤
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