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イソブチロニトリル

イソブチロニトリル 化学構造式
78-82-0
CAS番号.
78-82-0
化学名:
イソブチロニトリル
别名:
イソブチロニトリル;2-メチルプロパンニトリル;シアン化イソプロピル;2-メチルプロピオニトリル;イソプロピルシアニド;イソブタンニトリル;ジメチルアセトニトリル;2-メチルプロピオノニトリル;プロパン-2-カルボニトリル
英語化学名:
Isobutyronitrile
英語别名:
iso-C3H7CN;2-Cyanopropane;Isopropylkyanid;Isopropylcyanid;Isobutyronitril;Isopropylnitrile;ISOBUTYRONITRILE;Isobutanenitrile;ISOPROPYL CYANIDE;ISOPROPYL CYNAIDE
CBNumber:
CB9854381
化学式:
C4H7N
分子量:
69.11
MOL File:
78-82-0.mol

イソブチロニトリル 物理性質

融点 :
-72 °C
沸点 :
107-108 °C(lit.)
比重(密度) :
0.770 g/mL at 20 °C(lit.)
蒸気密度:
2.38 (vs air)
蒸気圧:
100 mm Hg ( 54.4 °C)
屈折率 :
n20/D 1.372(lit.)
闪点 :
39 °F
貯蔵温度 :
Flammables area
溶解性:
slightly soluble in water and acetone, very soluble in alcohol and ether
外見 :
Liquid
色:
Clear colorless to light yellow
水溶解度 :
35 g/L (20 ºC)
Merck :
14,5156
BRN :
1340512
安定性::
Stable. Flammable. May form explosive mixtures with air. Incompatible with strong oxidizing agents.
CAS データベース:
78-82-0(CAS DataBase Reference)
NISTの化学物質情報:
Propanenitrile, 2-methyl-(78-82-0)
EPAの化学物質情報:
Propanenitrile, 2-methyl-(78-82-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,T
Rフレーズ  11-23/24/25-36/37/38
Sフレーズ  9-16-24/25-26-36/37/39-45-23
RIDADR  UN 2284 3/PG 2
WGK Germany  2
RTECS 番号 TZ4900000
Hazard Note  Highly Flammable/Toxic
TSCA  Yes
国連危険物分類  3
容器等級  II
HSコード  29269095
有毒物質データの 78-82-0(Hazardous Substances Data)
毒性 LD50 (mg/kg): 25 i.p. in mice; 200 orally in rats (Zeller); LD50 orally in male mice: 0.3652 mmol/kg (Tanii)
化審法 2-1510
絵表示(GHS)
注意喚起語
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H330 吸入すると生命に危険 急性毒性、吸入 1, 2 危険 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
注意書き
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P320 特別な治療が緊急に必要である(このラベ ルの...を見よ)。
P330 口をすすぐこと。
P405 施錠して保管すること。

イソブチロニトリル 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

イソブチロニトリル 化学特性,用途語,生産方法

外観

無色~うすい黄色, 澄明の液体

溶解性

水に微溶 (3.5%, 20℃)。エタノール, エーテルに易溶。

化学的特性

colourless liquid

使用

Solvent.

調製方法

Isobutyronitrile is prepared from isobutyraldehyde by cyanation with ammonia.

一般的な説明

A clear colorless liquid. Flash point 47°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

空気と水の反応

Highly flammable. Slightly soluble in water.

反応プロフィール

Isobutyronitrile is incompatible with the following: Oxidizers, reducing agents, strong acids & bases .

危険性

Toxic by ingestion, inhalation, and skin absorption.

健康ハザード

Poisonous; may be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes. (Non-Specific -- Nitriles) Primarily, they are skin and eye irritants. Large doses cause collapse and stop breathing.

健康ハザード

Isobutyronitrile is considered highly hazardous and full precautions should be taken to prevent skin contact or inhalation of vapor. Inhaled isobutyronitrile is about 2.4 times as toxic as acetonitrile in rats. In order to protect workers, the recommended TWA limit is obtained by dividing that for acetonitrile by the factor 2.4. NIOSH has therefore recommended that employee exposure should not exceed 8 p.p.m. (22 mg/m3) for either compound as a TLV-TWA .
Isobutyronitrile was implicated in several cases of industrial poisoning. Thiess and Hey reported that a worker became unconscious following isobutyronitrile exposure. His immediate symptomatology included convulsive movements of upper limbs, soft and thready pulse, dilated pupils, shallow and gasping breathing and secretion of viscous mucus. After hospital admission, an exacerbation of the condition occurred with tonic-clonic movements of the upper extremities. The patient was cyanotic, the pulse faint and thready. The patient was treated intravenously with noradrenaline (1 mg) followed by amyl nitrite, sodium nitrite, and sodium thiosulphate. The man's cyanotic condition diminished and his pulse strengthened, although his gasping breath and upper limb convulsions continued. He was given intravenous injections of lobeline and phenobarbital. Rapid improvement occurred and the patient recovered gradually, leaving the hospital symptom-free at 14 d after admission. Two milder inhalation exposures of isobutyronitrile were reported by Zeller et al in which an unknown concentration of vapor produced headache, dizziness, and vomiting at 10-60 min after exposure. The intensity of symptoms varied with the concentration and duration of exposure.

火災危険

Vapor may explode if ignited in an enclosed area. Toxic oxides of nitrogen are produced during combustion. Isobutyronitrile is a flammable/combustible material and may be ignited by heat, sparks, or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Hazardous polymerization may not occur.

工業用途

Isobutyronitrile is used in organic synthesis, as a catalyst in the polymerization of ethylene and in the petroleum industry as a gasoline additive.

代謝

Thiocyanate was present in the urine of rats dosed orally with isobutyronitrile.

純化方法

Shake the nitrile with conc HCl (to remove isonitriles), then with water and aqueous NaHCO3. After a preliminary drying with silica gel or Linde type 4A molecular sieves, it is shaken or stirred with CaH2 until hydrogen evolution ceases, then decanted and distilled from P2O5 (not more than 5g/L, to minimize gel formation) or Drierite (b 101-103o/760mm). Finally it is refluxed with, and slowly distilled from CaH2 (5g/L), taking precautions to exclude moisture. [Beilstein 2 H 294, 2 I 129, 2 II 263, 2 III 655, 2 IV 853.]

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78-82-0(イソブチロニトリル)キーワード:


  • 78-82-0
  • Isopropylcyanid
  • Isopropylkyanid
  • Isopropylnitrile
  • Propanenitrile,2-methyl-
  • Propenenitrile,2-methyl-
  • α-Methylpropanenitrile
  • 1-Cyano-1-methylethane
  • α-Methylpropionitrile
  • 2-METHYLPROPANENITRILE
  • 2-METHYLPROPIONITRILE
  • ISOPROPYL CYANIDE
  • ISOPROPYL CYNAIDE
  • ISOBUTYRONITRILE
  • isiobutyronitrile
  • 2-Cyanopropane
  • 2-methyl-propanenitril
  • 2-methyl-propanoicacinitrile
  • alpha-Methylpropanenitrile
  • Dimethylacetonitrile
  • Isobutanenitrile
  • Isobuttersαurenitril
  • isobutyricacidnitrile
  • Isobutyronitril
  • iso-C3H7CN
  • Isobutylronitrile
  • #niso-Butyronitrile
  • ISOBUTYRONITRILE, 99.6%
  • Azobis (2-methylpropionitrile)
  • 2-Methylpropanrnitrile
  • 2-Methylpropanenitrile, 2-Methylpropionitrile, Isopropyl cyanide
  • イソブチロニトリル
  • 2-メチルプロパンニトリル
  • シアン化イソプロピル
  • 2-メチルプロピオニトリル
  • イソプロピルシアニド
  • イソブタンニトリル
  • ジメチルアセトニトリル
  • 2-メチルプロピオノニトリル
  • プロパン-2-カルボニトリル
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