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Losartan Carboxaldehyde

Losartan Carboxaldehyde 구조식 이미지

카스 번호:: 114798-36-6

상품명:: Losartan Carboxaldehyde

동의어(영문):: DUP 167;EXP 3179;Losartan Aldehyde;Losartan EP IMpurity K;Losartan Carboxaldehyde;Losartan Impurity K (EP);Losartan Carboxaldehyde-d3;Losartan Related CoMpound C;Losartan USP Related Compound C;Allisartan Isoproxil impurity II

CBNumber:: CB01176401

분자식:: C22H21ClN6O

포뮬러 무게:: 420.89

MOL 파일:: 114798-36-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 77

Losartan Carboxaldehyde 속성

녹는점: 84-86°C

끓는 점: 666.7±65.0 °C(Predicted)

밀도: 1.34±0.1 g/cm3(Predicted)

저장 조건: Refrigerator, Under Inert Atmosphere

용해도: 클로로포름(약간 용해됨), 에탄올(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 4.16±0.10(Predicted)

색상: 황백색에서 밝은 노란색까지

CAS 데이터베이스: 114798-36-6

안전

HS 번호	2933290000

Losartan Carboxaldehyde C화학적 특성, 용도, 생산

개요

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A₂ and prostaglandin F_2α . Losartan carboxaldehyde can also act as a partial agonist (EC₅₀ = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

화학적 성질

Yellow Solid

용도

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

Losartan Carboxaldehyde 준비 용품 및 원자재

원자재

준비 용품

N-Trityl Losartan Carboxaldehyde

Losartan Carboxaldehyde 공급 업체

글로벌( 77)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12431	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58

Losartan Carboxaldehyde 관련 검색:

Losartan carboxylic acid N2-Losartanyl-losartan (Losartan IMpurity) Losartan IsoMer IMpurity, PotassiuM Salt 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]Methanol N1-Losartanyl-losartan (Losartan IMpurity) Triphenylmethanol 2-Butyl-4-chloro-5-formylimidazole Losartan Impurity D 5-(4'-((2-butyl-4-chloro-5-(isopropoxymethyl)-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE Losartan IMpurity C (Isolosartan) O-Acetyl Losartan Losartan potassium Losartan Losartan Carboxaldehyde AKOS 91711 AKOS 91707