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Difenoxinum

Difenoxinum 구조식 이미지
카스 번호:
28782-42-5
상품명:
Difenoxinum
동의어(영문):
Difenoxine;Difenoxinum;McN-JR-15403-11;Difenoxilic Acid;Difenoxylic Acid;Diphenoxylic Acid;Diphenoxylate Impurity A;UFIVBRCCIRTJTN-UHFFFAOYSA-N;Diphenoxylate EP impurity A;1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid
CBNumber:
CB01178506
분자식:
C28H28N2O2
포뮬러 무게:
0
MOL 파일:
28782-42-5.mol

Difenoxinum 속성

끓는 점
632.7±55.0 °C(Predicted)
밀도
1.175±0.06 g/cm3(Predicted)
산도 계수 (pKa)
3.55±0.20(Predicted)

안전

HS 번호 2933330000

Difenoxinum C화학적 특성, 용도, 생산

Originator

Lyspafena,Cilag Chemie,W. Germany,1980

용도

The active metabolite of Diphenoxylate. Antiperistaltic; antidiarrheal. This is a controlled substance (opiate).

정의

ChEBI: A piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group.

Manufacturing Process

To a stirred solution of 5.52 parts of t-potassiurn butanolate in 60 parts of dimethylsulfoxide are added 1.7 parts of ethyl-1-(3-cyano-3,3- diphenylpropyl)-4-phenylisonipecotate hydrochloride and the whole is stirred on an oil bath (90°C) for 4 hours. The reaction mixture is cooled (30°C) and poured onto 180 parts of water with stirring. After two extractions with benzene, the aqueous phase is acidified with glacial acetic acid to pH 6.5 with stirring. The precipitated product is filtered off, washed with water, dried, dissolved in 50 parts of 0.4 N potassium hydroxide and precipitated again with glacial acetic acid. The crude free base is filtered off and dissolved in a mixture of 2-propanol and chloroform and gaseous hydrogen chloride is introduced into the solution. The whole is filtered and the filtrate is evaporated. The residue is mixed with benzene and the latter is evaporated again. The residue is recrystallized from 2-propanol, yielding 1-(3-cyano-3,3- diphenylpropyl)-4-phenylisonipecotic acid hydrochloride.

상표명

Dioctin;Lyspafen;Lyspofenac;Motofen.

Therapeutic Function

Antiperistaltic

World Health Organization (WHO)

Difenoxin is the principal metabolite of diphenoxylate. See WHO comment for diphenoxylate.

Difenoxinum 준비 용품 및 원자재

원자재

준비 용품


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