ChemicalBook >제품 카탈로그 >Pyronaridine

Pyronaridine

Pyronaridine 구조식 이미지

카스 번호:: 74847-35-1

상품명:: Pyronaridine

동의어(영문):: Pyronaridine;Malaridine phosphate;4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-...;4-(2-Methoxy-6-chloro-1,10-diazaanthracene-9-ylamino)-2,6-bis(pyrrolizinomethyl)phenol;4-(7-chloro-2-Methoxybenzo[b][1,5]naphthyridin-10-ylaMino)-2,6-bis(pyrrolidin-1-ylMethyl)phenol;4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol;Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-;4-[(7-CHLORO-2-METHOXY-1,5-DIHYDROBENZO[B][1,5]NAPHTHYRIDIN-10-YL)IMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)CYCLOHEXA-2,5-DIEN-1-ONE

CBNumber:: CB01179619

분자식:: C29H32ClN5O2

포뮬러 무게:: 518.05

MOL 파일:: 74847-35-1.mol

속성

안전

용도

공급 업체 46

Pyronaridine 속성

끓는 점: 621.3±55.0 °C(Predicted)

밀도: 1.356±0.06 g/cm3 (20℃ 760 Torr)

굴절률: 1.5650 (estimate)

용해도: DMSO(약간 용해됨), 물(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 8.20±0.50(Predicted)

색상: 연한 노란색에서 주황색까지

안정성: 강한 산화제와 호환되지 않습니다.

CAS 데이터베이스: 74847-35-1

안전

Pyronaridine C화학적 특성, 용도, 생산

화학적 성질

solid

Antimicrobial activity

Pyronaridine is active against the asexual erythrocytic stage of P. falciparum with little or no activity against gametocytes or the hepatic stage. In-vitro blood schizonticide activities are in the range of 0.001–0.03 mg/L, showing a moderate correlation to chloroquine resistance. However, this correlation varies between studies and does not seem to be clinically significant. It is also active against P. vivax, P. ovale and P. malariae. Antagonistic interactions with artemisinins were reported in vitro, but synergy with artesunate has been observed in rodent models.

원료

Decreasing in-vitro sensitivity has been observed in China.

Pharmaceutical Applications

An aza-aminoacridine formulated for oral use. A Mannichbase derivative of mepacrine.

Pharmacokinetics

Peak plasma concentrations are reached after 3–14 h depending upon the formulation; there is also considerable interindividual variation. Elimination half-lives of 63–190 h have been reported, again dependent upon the formulation.

Clinical Use

Treatment of uncomplicated P. falciparum and P. vivax malaria
A fixed-dose combination with artesunate (Pyramax) is being developed for uncomplicated P. falciparum and P. vivax malaria.

부작용

It is well tolerated and no outstanding toxic effects have been reported.

Pyronaridine 준비 용품 및 원자재

원자재

준비 용품

Pyronaridine 공급 업체

글로벌( 46)공급 업체

공급자	전화	이메일	국가	제품 수	이점
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	906	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	2263	58
zhangjiagang vinsce bio-pharm. limited.	86-512-58389969	sales1@swellxin.com	CHINA	111	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58

Pyronaridine 관련 검색:

Potassium Phosphate Monobasic 1,5-NAPHTHYRIDINE Amodiaquin dihydrochloride dihydrate 1,5-NAPHTHYRIDIN-4-AMINE 2-Hydroxy-1,5-naphthyridine Pyranoridine phosphate N-DESETHYL AMODIAQUINE 3-(PYRROLIDIN-1-YLMETHYL)ANILINE M6407 [3-(1-PYRROLIDINYLMETHYL)PHENYL]METHANAMINE 1-{3-[(METHYLAMINO)METHYL]BENZYL}PYRROLIDINE 90+%N-METHYL-3-(PYRROLIDIN-1-YLMETHYL)BENZYLAMINE 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE Pyronaridine Amopyroquine