N-BUTYLDEOXYNOJIRIMYCIN
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N-BUTYLDEOXYNOJIRIMYCIN 속성
- 녹는점
- 126-127℃
- 알파
- D25 -15.9° (c = 0.77 in water)
- 끓는 점
- 394.7±42.0 °C(Predicted)
- 밀도
- 1.234
- RTECS 번호
- TN4350150
- 저장 조건
- 2-8°C
- 용해도
- DMSO 44 mg/mL (200.66 mM) Ethanol 22 mg/mL (100.33 mM) Water 44 mg/mL (200.66 mM)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 13.72±0.70(Predicted)
- 색상
- 하얀색
- 수용성
- 10mg/ml의 물에 용해됨
- InChIKey
- UQRORFVVSGFNRO-UTINFBMNSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 3 | ||
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HS 번호 | 2933399990 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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N-BUTYLDEOXYNOJIRIMYCIN C화학적 특성, 용도, 생산
개요
Miglustat is an N-alkylated iminosugar, launched as an oral treatment for mild to moderate type 1 Gaucher’s disease in adult patients for whom enzyme replacement therapy is not a therapeutic option. It is readily synthesized from D-glucose in three steps by first converting to N-butylglucamine via reductive amination with butylamine, followed by a microbial oxidation to an aminofuranose intermediate and subsequent reductive cyclization. Type 1 Gaucher’s disease is a metabolic disorder caused by the lysosomal accumulation of certain glycosphingolipids (GSLs) as a result of deficiency in their degradation. Enlargement of the liver and spleen, low blood platelet and bone lesions are among the key symptoms of this disease. Miglustat acts by inhibiting glucosylceramide synthase, a glucosyl transferase enzyme in the biosynthesis of most GSLs, which results in the lowering of GSLs to a level that can be effectively cleared. Up to 50% reduction in liver and splenocyte GSL levels are achieved in mice by long-term administration of Miglustat (600– 1800 mg/kg/day for 118 days). Miglustat, dosed at 50 and 100 mg in Gaucher patients, exhibits dose proportionate pharmacokinetics (tmax=2.5 h, t1/2=6 to 7 h) and >90% oral bioavailability. Steady-state plasma levels are reached after 4–6 weeks of treatment. Miglustat is not significantly metabolized in humans and the major route of excretion is renal. In clinical trials, efficacy was demonstrated by significant reductions in liver and spleen volumes (12 and 19%, respectively) at 12 months and increase in hemoglobin and platelet count (0.91 g/dL and 13.6×109/l, respectively) at 24 months. Miglustat is generally well tolerated by patients and the most common side effects are diarrhea and weight loss.용도
Treatment of glycolipid storage diseases.정의
ChEBI: A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.일반 설명
N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.생물학적 활성
Orally active α -glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER α -glucosidases I and II. Also has broad spectrum antiviral activity.N-BUTYLDEOXYNOJIRIMYCIN 준비 용품 및 원자재
원자재
준비 용품
N-BUTYLDEOXYNOJIRIMYCIN 공급 업체
글로벌( 131)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
N-BUTYLDEOXYNOJIRIMYCIN 관련 검색:
코코/올레아미도프로필베테인
2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol
Deionized water
1-Deoxynojirimycin
N-Dodecyldeoxynojirimycin
N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN
N-(7-Oxa-9,9,9-trifluorononyl)deoxynojirimycin
N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE
N-(7-Oxadecyl)deoxynojirimycin
CAMIGLIBOSE
N-5-Carboxypentyl-1-deoxynojirimycin
N-(n-Nonyl)deoxynojirimycin
N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN
N-BUTYLDEOXYNOJIRIMYCIN, HYDROCHLORIDE
glycovir
N-BUTYLDEOXYNOJIRIMYCIN