아미노시클로부탄
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아미노시클로부탄 속성
- 녹는점
- 133-135.5 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))
- 끓는 점
- 81.5 °C752 mm Hg(lit.)
- 밀도
- 0.833 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.437(lit.)
- 인화점
- 24 °F
- 저장 조건
- 2-8°C
- 산도 계수 (pKa)
- 10.80±0.20(Predicted)
- 물리적 상태
- 액체
- 색상
- 무색투명~연황색
- 수용성
- 약간 용해됨
- 감도
- Hygroscopic
- BRN
- 2069297
- InChIKey
- KZZKOVLJUKWSKX-UHFFFAOYSA-N
- CAS 데이터베이스
- 2516-34-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,C,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 11-34-20/21/22-36/37/38 | ||
안전지침서 | 16-26-36/37/39-45-33-7/9 | ||
유엔번호(UN No.) | UN 2733 3/PG 2 | ||
WGK 독일 | 3 | ||
위험 등급 | 3 | ||
포장분류 | II | ||
HS 번호 | 29213000 | ||
기존화학 물질 | KE-09130 |
아미노시클로부탄 C화학적 특성, 용도, 생산
화학적 성질
Clear colorless to light yellow liquid용도
Cyclobutylamine is a substrate employed in a microwave-assisted synthesis of 7-azaindoles from dihalopyridines. Also it is a reactant in the preparation of imidazo[1,2-b]pyridazine derivatives as selective and orally available Mps1 (TTK) kinase inhibitors.제조 방법
The preparation of cyclobutylamine from cyclobutanecarboxylic acid and hydrazoic acid has been reported previously. Cyclobutylamine has also been prepared by the Hofmann-type rearrangement of cyclobutanecarboxamide. More recently it has been prepared in 82–87% overall yield from cyclobutanecarboxamide by oxidative rearrangement with lead tetraacetate or iodosobenzene diacetate.Synthesis of cyclobutylamine
Purification Methods
It has been purified by steam distillation. The aqueous distillate (e.g. 2L) is acidified with 3N HCl (90mL) and evaporated to dryness in a vacuum. The hydrochloride is treated with a few mL of H2O, cooled in ice and a slush of KOH pellets ground in a little H2O is added slowly in portions and keeping the solution very cold. The amine separates as an oil from the strongly alkaline solution. The oil is collected, dried over solid KOH and distilled using a vacuum jacketed Vigreux column (p 11) and protected from CO2 using a soda lime tube. The fraction boiling at 79-83o is collected, dried over solid KOH for 2days and redistilled over a few pellets of KOH (b 80.5-81.5o). Best distil in a dry N2 atmosphere. The purity can be checked by GLC using a polyethylene glycol on Teflon column at 72o, 15 psi, flow rate of 102 mL/min of He. The sample can appear homogeneous but because of tailing it is not possible to tell if H2O is present. The NMR in CCl4 should show no signals less than 1 ppm from TMS. The hydrochloride has a multiplet at ca 1.5-2.6ppm (H 2,2,4,3,3,4,4), a quintet at 3.8 ppm (H 1) and a singlet at 4.75 for NH2 [Roberts & Chambers J Am Chem Soc 73 2509 1951]. The benzenesulfonamide has m 85-86o (from aqueous MeOH) and the benzoyl derivative has m 120.6-121.6o. [Roberts & Mazur J Am Chem Soc 73 2509 1951, Iffland et al. J Am Chem Soc 75 4044 1953, Werner & Casanova Jr Org Synth Coll Vol V 273 1973, Beilstein 12 IV 3.]아미노시클로부탄 준비 용품 및 원자재
원자재
준비 용품
아미노시클로부탄 공급 업체
글로벌( 259)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
BTC Nantong Pharmaceuticals Technology Co.,Ltd | +8618068193575 |
sales4@btcpharm.com | China | 254 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 |
sales06@hbduling.cn | China | 8056 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9355 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2136 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8820 | 58 |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 |
info@edengenechem.com | China | 2169 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
아미노시클로부탄 관련 검색:
시클로헥실아민 아미카신 알부테롤 황산염 테트라부틸암모늄 브로마이드 트리부틸아민 아미노시클로부탄
3-Azetidinecarboxylic acid
N-(n-Butyl)thiophosphoric triamide
DOBUTAMINE
Salbutamol
CYCLOBUTYL-ACETIC ACID
tert-butyl cyclopropanecarboxylate
Cyclopropylboronic acid
Methyl cyclopropane carboxylate
Sulfolane
Cyclobutanecarboxylic acid
Cyclobutanemethanol
Cyclobutanecarbonitrile