berninamycin A

berninamycin A C화학적 특성, 용도, 생산

용도

Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central to multidrug resistance. Berninamycin A is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

효소 저해제

This fungal antibiotic (FW = 1146.12 g/mol; CAS 58798-97-3; Soluble in DMSO), also known as Antibiotic U27810, from Streptomyces bernensis inhibits protein biosynthesis by binding to a complex formed by ribosomal 23S and the L11 protein, thereby disrupting the function of the ribosome’s A site and inhibiting protein synthesis in Gram-positive bacteria. In this respect, it has the same mode of action as thiostrepton. Streptomyces bernensis and Streptomyces azureus, which produce berninamycin and thiostrepton, respectively, possess similar ribosomal RNA methylases that mediate specific pentose-directed methylation of 23S ribosomal RNA, rendering the modified ribosomes resistant to these antibiotics.

berninamycin A 준비 용품 및 원자재

원자재

준비 용품

berninamycin A 공급 업체

공급자	전화	이메일	국가	제품 수	이점
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55791	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Meng Cheng Technology (Shanghai) Co., LTD	400-820-6829	sales@mitachieve.com	China	8864	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58