Nimesulide
|
|
Nimesulide 속성
- 녹는점
- 140-146°C
- 끓는 점
- 442.0±55.0 °C(Predicted)
- 밀도
- 1.451±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 물에 거의 녹지 않으며, 아세톤에 잘 녹고, 무수 에탄올에 약간 녹습니다.
- 산도 계수 (pKa)
- pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
- 색상
- Light orange to Yellow to Green
- 수용성
- 수용성(<50μg/ml), 1:10 DMSO:PBS(pH 7.2)(<200μg/ml), 에탄올(1mg/ml), DMSO (15mg/ml), DMF(15mg/ml), 에 용해됨클로로포름, 에 용해됨디클로로메탄, 아세톤(자유롭게 용해됨) 및 1N NaOH.
- 최대 파장(λmax)
- 391nm(H2O)(lit.)
- Merck
- 14,6548
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- HYWYRSMBCFDLJT-UHFFFAOYSA-N
- CAS 데이터베이스
- 51803-78-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 36-26 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | PB0970000 | ||
| HS 번호 | 2935.90.9500 | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | III | ||
| 독성 | LD50 orally in rats: 324 mg/kg (Swingle, Moore) |
Nimesulide C화학적 특성, 용도, 생산
개요
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.화학적 성질
Yellow Needle-Like Crystals용도
Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.일반 설명
Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.생물학적 활성
Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.Clinical Use
Nimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.참고 문헌
https://en.wikipedia.org/wiki/Nimesulidehttps://www.drugbank.ca/drugs/DB04743
Nimesulide 준비 용품 및 원자재
원자재
Organic base
에틸알코올
디페닐에테르
메탄설포닐 클로라이드
브로모벤젠
디클로로메탄
아세트산(빙초산)
4-Nitro-2-phenoxyaniline
(2-PHENOXY)METHYLSULFONYLANILINE
N-(2-Hydroxy-4-nitrophenyl)-phtalimide
2-아미노-5-니트로페놀
준비 용품
Nimesulide 공급 업체
글로벌( 553)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12457 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 305 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 |
da@zhongda-biotech.com | China | 248 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 |
justine@zhongda-biotech.com | China | 300 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 |
linda@zhongda-biotech.com | China | 204 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 |
sarah@tnjone.com | China | 864 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |