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Olopatadine hydrochloride

Olopatadine hydrochloride 구조식 이미지
카스 번호:
140462-76-6
상품명:
Olopatadine hydrochloride
동의어(영문):
Patanol;AL-4943A;Opatanol;Olopatadin HCL;OLAPATADINE HCL;OLOPATADINE HCL;OLOPATDINEHYDROCHLORIDE;Olopatadine Hydrochlorde;OLOPATADINE HYDROCHLORIDE;Olopatadin HCL (DFM Gr)INN
CBNumber:
CB0144403
분자식:
C21H24ClNO3
포뮬러 무게:
373.87316
MOL 파일:
140462-76-6.mol

Olopatadine hydrochloride 속성

녹는점
242-245?C
저장 조건
Refrigerator
용해도
H2O: ≥20mg/mL
물리적 상태
solid
Merck
14,6840
InChIKey
HVRLZEKDTUEKQH-NOILCQHBSA-N
CAS 데이터베이스
140462-76-6(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,N
위험 카페고리 넘버 25-50
안전지침서 45-61
유엔번호(UN No.) UN 2811 6.1 / PGIII
WGK 독일 3
RTECS 번호 HQ4135060
HS 번호 29329990
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H400 수생생물에 매우 유독함 수생 환경유해성 물질 - 급성 구분 1 경고 P273, P391, P501
예방조치문구:
P273 환경으로 배출하지 마시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

Olopatadine hydrochloride C화학적 특성, 용도, 생산

개요

Patanol was launched in the US for use in allergic conjunctivitis. It can be prepared in five steps from the sodium salt of phydroxyphenylacetic acid methyl ester with phthalide. It has a fast onset of action with a long duration of action (due to slow dissociation kinetics) that combines the ability to prevent human conjunctival mast cell mediator release with selective H1-receptor antangonistic activity (greater H3:H1 selectivity than H2:H1 selectivity). In addition, Patanol had no inhibition of 5- lipoxygenase, PAF acetyltransferase and thromboxane synthase while interfering with phospholipase A2. It has a presynaptic inhibition of tachykinin release and inhibits bronchial sensory nerves through activation of small conductance calcium activated potassium channels. It was more potent than ketotifen and terfenadine and was effective at inhibition of PAF, LTC4 induced conjunctivitis and TXB2 production. It does not accumulate in the CNS, has a low affinity for H1-receptors in the brain, and significantly inhibits allergen induce sneezing. Patanol was more effective in conjuctival than in corneal or the trabecuiar meshwork cells.

화학적 성질

White Solid

Originator

Kyowa Hakko (Japan)

용도

Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.

용도

antiallergic, antihistaminic;histamine H1 antagonist

용도

urinary antispasmodic

용도

Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]

상표명

Patanol (Alcon).

Veterinary Drugs and Treatments

Olopatadine HCl is a selective H1 receptor antagonist and inhibitor of histamine release from mast cells. It is marketed for topical use to alleviate symptoms of allergic conjunctivitis in humans and is thought to be safe for use in children three years of age and older. Olopatadine, upon topical application in humans, was shown to have very limited systemic absorption. It was detectable in the milk of nursing rats, after topical application, and like most medications should be avoided in pregnant or nursing animals.

Olopatadine hydrochloride 준비 용품 및 원자재

원자재

준비 용품


Olopatadine hydrochloride 공급 업체

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