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덱사메타손 나트륨 인산염

덱사메타손 나트륨 인산염
덱사메타손 나트륨 인산염 구조식 이미지
카스 번호:
2392-39-4
한글명:
덱사메타손 나트륨 인산염
동의어(한글):
덱사메타손나트륨인산염;덱사메타손나트륨인산염
상품명:
Dexamethasone 21-phosphate disodium salt
동의어(영문):
Ak-Dex;Baldex;Decdan;dexagro;Dexagel;Dalalone;Dexabene;megacort;soldesam;Colvasone
CBNumber:
CB0153737
분자식:
C22H28FNa2O8P
포뮬러 무게:
516.4
MOL 파일:
2392-39-4.mol

덱사메타손 나트륨 인산염 속성

녹는점
233-235 °C
알파
D +57° (water); D25 +74 ±4° (calcd on water-free and alcohol-free basis, concn of 10 mg/ml): USP XIX, p 124
저장 조건
2-8°C
용해도
H2O: 50 mg/mL, clear, faintly yellow
물리적 상태
White Powder
색상
white to off-white
수소이온지수(pH)
pH(10g/l, 25℃) : 7.5~10.5
수용성
Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
Merck
13,2960
BRN
6473066
InChIKey
PLCQGRYPOISRTQ-FCJDYXGNSA-L
CAS 데이터베이스
2392-39-4(CAS DataBase Reference)
EPA
Dexamethasone disodium phosphate (2392-39-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-40-63
안전지침서 36/37/39
WGK 독일 3
RTECS 번호 TU4056000
F 고인화성물질 3-10
TSCA Yes
HS 번호 2937220000
기존화학 물질 KE-17064
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281 요구되는 개인 보호구를 착용하시오
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.

덱사메타손 나트륨 인산염 C화학적 특성, 용도, 생산

화학적 성질

White or almost white, very hygroscopic powder.

Originator

Decadron Phosphate,MS and D,US,1959

용도

Dexamethasone-21-phosphate disodium salt is used in eye and ear preparations and in systemic preparations.

용도

glucocorticoid, antiinflammatory

용도

Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

정의

ChEBI: An organic sodium salt which is the disodium salt of dexamethasone phosphate.

Manufacturing Process

A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.

상표명

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Therapeutic Function

Glucocorticoid

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: peritonitis, central nervous system, and gastrointestinal changes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F-, PO,, and Na2O.

덱사메타손 나트륨 인산염 준비 용품 및 원자재

원자재

준비 용품


덱사메타손 나트륨 인산염 공급 업체

글로벌( 386)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
APOLLO HEALTHCARE RESOURCES
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Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
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0371-55170693 info@tianfuchem.com China 22607 55
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02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
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86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
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SHANDONG ZHI SHANG CHEMICAL CO.LTD
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+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5943 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

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