ANTI-BIP C화학적 특성, 용도, 생산
용도
Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
일반 설명
GRP78/BiP is a Ca
2+-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.
Biochem/physiol Actions
GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca2+ ionophores, inhibition of the ER Ca2+ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca2+ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).
ANTI-BIP 준비 용품 및 원자재
원자재
준비 용품
