18-HYDROXY-11-DEOXYCORTICOSTERONE
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18-HYDROXY-11-DEOXYCORTICOSTERONE 속성
- 녹는점
- 171-173 °C
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름(약간 용해됨, 초음파 처리), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- LogP
- 1.571 (est)
안전
| 안전지침서 | 22-24/25 |
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18-HYDROXY-11-DEOXYCORTICOSTERONE C화학적 특성, 용도, 생산
개요
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.용도
11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.Purification Methods
Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]18-HYDROXY-11-DEOXYCORTICOSTERONE 준비 용품 및 원자재
원자재
준비 용품
18-HYDROXY-11-DEOXYCORTICOSTERONE 공급 업체
글로벌( 20)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
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| BOC Sciences | -- |
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| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 |
1046@dideu.com | China | 10008 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 |
info@scrbio.com | China | 9260 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 |
customer_service@efebio.com | China | 8740 | 58 |
| United States Biological | -- |
sales@advtechind.com | United States | 6106 | 58 |