비마토프로스트
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비마토프로스트 속성
- 녹는점
- 66-68°C
- 끓는 점
- 629.8±55.0 °C(Predicted)
- 밀도
- 1.145±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- 클로로포름(약간 용해됨), 디클로로메탄(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 14.25±0.20(Predicted)
- 색상
- 흰색에서 황백색까지
- BCS Class
- 3
- 안정성
- 감광성
- InChIKey
- AQOKCDNYWBIDND-FTOWTWDKSA-N
- SMILES
- C(NCC)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1
- CAS 데이터베이스
- 155206-00-1(CAS DataBase Reference)
비마토프로스트 C화학적 특성, 용도, 생산
개요
Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF2α analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F2α followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.화학적 성질
Crystalline Solid용도
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha일반 설명
Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.비마토프로스트 준비 용품 및 원자재
원자재
준비 용품
비마토프로스트 공급 업체
글로벌( 569)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Shenzhen Monkono Technology Co.,Ltd | +86-17063441314 |
sansbiotech@outlook.com | China | 677 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 988 | 58 |
Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 |
admin@hbdangtong.com | China | 1005 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 153 | 58 |
비마토프로스트 관련 검색:
2-페닐페놀 트리페닐포스핀 3차-아밀 메틸 에테르
Prostaglandin E2
Epoprostenol
Hydroxy silicone oil
CHLOROPHOSPHONAZO III
Prostaglandin E1
Travoprost
Latanoprost
(5-(ethylamino)-5-oxopentyl)triphenylphosphonium bromide
Phenylacetone
2-Chlorophenyl cyclopentyl ketone
BIMATOPROST(TM) (FREE ACID)
17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA AMIDE
Bimatoprost
BIMATOPROST(TM)-D4 (FREE ACID)
17-P-PGF2ALPHA-NET2