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비마토프로스트

비마토프로스트
비마토프로스트 구조식 이미지
카스 번호:
155206-00-1
한글명:
비마토프로스트
동의어(한글):
비마토프로스트
상품명:
Bimatoprost
동의어(영문):
Bima;CS-2897;LUMIGAN;BiMapnost;Prostamide;BIMATOPROST;BIMATOPROST(TM);Bimatoprost API;buprostaglandin;cGMP Bimatoprost
CBNumber:
CB0171421
분자식:
C25H37NO4
포뮬러 무게:
415.57
MOL 파일:
155206-00-1.mol

비마토프로스트 속성

녹는점
66-68°C
끓는 점
629.8±55.0 °C(Predicted)
밀도
1.145±0.06 g/cm3(Predicted)
저장 조건
−20°C
산도 계수 (pKa)
14.25±0.20(Predicted)
물리적 상태
solid
InChIKey
AQOKCDNYWBIDND-FTOWTWDKSA-N
CAS 데이터베이스
155206-00-1(CAS DataBase Reference)

안전

WGK 독일 3

비마토프로스트 C화학적 특성, 용도, 생산

개요

Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.

화학적 성질

Crystalline Solid

Originator

Allergan (US)

용도

Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2a.

용도

Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2α.

용도

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha

용도

Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.

용도

17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.[Cayman Chemical]

상표명

Lumigan (Allergan).

일반 설명

Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.

비마토프로스트 준비 용품 및 원자재

원자재

준비 용품


비마토프로스트 공급 업체

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