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α-Naphthoflavone

α-Naphthoflavone 구조식 이미지
카스 번호:
604-59-1
상품명:
α-Naphthoflavone
동의어(영문):
BENZOFLAVONE;benzo(h)flavone;-Naphthoflavone;à-naphthoflavone;7,8-BENZOFLAVONE;A-NAPHTHOFLAVONE;1-Naphthoflavone;α-Naphthylflavone;a-Naphthylflavone;NAPHTHOFLAVONE, A-
CBNumber:
CB0184955
분자식:
C19H12O2
포뮬러 무게:
272.3
MOL 파일:
604-59-1.mol

α-Naphthoflavone 속성

녹는점
153-157 °C(lit.)
끓는 점
375.35°C (rough estimate)
밀도
1.1382 (rough estimate)
굴절률
1.5510 (estimate)
저장 조건
2-8°C
물리적 상태
Crystalline Powder or Crystals
색상
yellow
BRN
210862
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
604-59-1(CAS DataBase Reference)

안전

위험품 표기 Xi,Xn,C,F
위험 카페고리 넘버 68-34-11
안전지침서 24/25-36/37-45-36/37/39-26-16
WGK 독일 3
RTECS 번호 QL6250000
F 고인화성물질 8
위험 참고 사항 Irritant
TSCA Yes
HS 번호 29143990

α-Naphthoflavone C화학적 특성, 용도, 생산

화학적 성질

yellow powder

용도

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]

정의

ChEBI: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).

Purification Methods

Recrystallise the flavone from EtOH or aqueous EtOH. [IR: Cramer & Windel Chem Ber 89 354 1956, UV Pillon & Massicot Bull Soc Chim Fr 26 1954, Smith J Chem Soc 542

α-Naphthoflavone 준비 용품 및 원자재

원자재

준비 용품


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