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MG-115

MG-115 구조식 이미지
카스 번호:
133407-86-0
상품명:
MG-115
동의어(영문):
MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)
CBNumber:
CB0195607
분자식:
C25H39N3O5
포뮬러 무게:
461.59
MOL 파일:
133407-86-0.mol

MG-115 속성

끓는 점
678.8±55.0 °C(Predicted)
밀도
1.082±0.06 g/cm3(Predicted)
저장 조건
-20°C
용해도
DMSO: soluble
산도 계수 (pKa)
11.14±0.46(Predicted)
물리적 상태
powder
색상
white

안전

WGK 독일 3

MG-115 C화학적 특성, 용도, 생산

개요

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

용도

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

용도

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

일반 설명

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Biochem/physiol Actions

Product does not compete with ATP.

MG-115 준비 용품 및 원자재

원자재

준비 용품


MG-115 공급 업체

글로벌( 69)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 896 58
Nextpeptide Inc
+8613336028439 +86-571-81612335
sales@nextpeptide.com China 19915 58
Alabiochem Tech.Co., Ltd. 13962259467 0512-58900862
0086-512-56765862 sales@alabiochem.com;sales@alabiochem.com China 1005 59
BOC Sciences 16314854226
info@bocsci.com United States 21113 65
Guangzhou Isun Pharmaceutical Co., Ltd 18927568969 020-39119399-
020-39119999 isunpharm@qq.com China 4575 55
ApexBio Technology LLC +1-832-696-8203
+1-832-641-3177 info@apexbt.com United States 477 60
Sigma-Aldrich 800-8193336 021-61415566-
orderCN@merckgroup.com;orderCN@merckgroup.com China 50837 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885 info@efebio.com China 9918 58
Alabiotech Inc. 001-619-354-5251
001-855-855-6087 sales@alabiotech-e.com United States 972 60
Shandong Ono Chemical Co., Ltd. 0539-6362799(To 20)
0539-6362799(To 20) 68188893@qq.com China 10009 58

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