LY 341495
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LY 341495 속성
- 끓는 점
- 580.8±40.0 °C(Predicted)
- 밀도
- 1.432
- 저장 조건
- Store at RT
- 용해도
- Limited solubility, soluble in DMSO
- 물리적 상태
- 결정질 고체
- 산도 계수 (pKa)
- 2.02±0.10(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
LY 341495 C화학적 특성, 용도, 생산
용도
LY 341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 μM, respectively). In rat forebrain tissue, LY341495 may bind mGluR3 more avidly than mGluR2. LY341495 can be effectively used in isolated cells, tissues, and in vivo. In mice, it penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.[Cayman Chemical]생물학적 활성
Highly potent and selective group II metabotropic glutamate receptor antagonist (K i /IC 50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu 2 , mGlu 3 , mGlu 8 , mGlu 7a , mGlu 1a , mGlu 5a and mGlu 4a receptors respectively). Readily brain penetrant and active in vivo . Also available as part of the Group II mGlu Receptor Tocriset™ , Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .LY 341495 준비 용품 및 원자재
원자재
준비 용품
LY 341495 공급 업체
글로벌( 94)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9923 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131981 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
Chembest Research Laboratories Limited | 021-20908456 |
sales@BioChemBest.com | China | 6011 | 61 |
Ascent Scientific | 4401179829988 |
customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
China | 1494 | 55 |
LY 341495 관련 검색:
(R)-1-(Cyclopropylethyl)amine
3-Methyl-1-phenethylbutylamine
(S)-1-CYCLOPROPYLETHYLAMINE
DL-2-METHYLGLUTAMIC ACID
(2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE
DL-2-AMINOADIPIC ACID
Cyclopropylacetic acid
L-Cyclopropylglycine
AMINO-CYCLOPROPYL-ACETIC ACID
L-2-Aminoadipic acid
H-ALPHA-ME-LEU-OH
2-AMINO-2-CYCLOPROPYLPROPIONIC ACID
ALPHA-METHYL-L-VALINE HYDROCHLORIDE
D-β-Homophenylalanine, HPLC 98%
(2S,4R)-4-METHYLGLUTAMIC ACID
(S)-2-AMINO-2-ETHYLHEXANOIC ACID
CHEMBRDG-BB 6156098
4-PHENYLISOVALINE