LUFFARIELLOLIDE

LUFFARIELLOLIDE 구조식 이미지
카스 번호:
111149-87-2
상품명:
LUFFARIELLOLIDE
동의어(영문):
LUFFARIELLOLIDE;3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone;2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
CBNumber:
CB0200705
분자식:
C25H38O3
포뮬러 무게:
386.57
MOL 파일:
111149-87-2.mol

LUFFARIELLOLIDE 속성

끓는 점
541.7±50.0 °C(Predicted)
밀도
1.006±0.06 g/cm3(Predicted)
용해도
DMSO: soluble; Ethanol: soluble
산도 계수 (pKa)
9.98±0.40(Predicted)
물리적 상태
연한 노란색 오일.
InChI
InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InChIKey
JPWPYTMXSXYUPG-QZPYEDBESA-N
SMILES
O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O

안전

LUFFARIELLOLIDE C화학적 특성, 용도, 생산

용도

Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).[Cayman Chemical]

LUFFARIELLOLIDE 준비 용품 및 원자재

원자재

준비 용품


LUFFARIELLOLIDE 공급 업체

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Wuhan Topule Biopharmaceutical Co., Ltd
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Aladdin Scientific
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
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Energy Chemical 021-58432009 400-005-6266
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MedBioPharmaceutical Technology Inc 021-69568360 18916172912
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QUALITY CONTROL SOLUTIONS LTD. 0755-66853366 15920483169
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amyjetsci 027-59626688 18771149750
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Wuhan Augda Biotechnology Co., Ltd 15071299552
262933239@qq.com China 6637 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822
czbjpharma@126.com China 18488 58

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