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Z-VAD-FMK

Z-VAD-FMK 구조식 이미지
카스 번호:
187389-52-2
상품명:
Z-VAD-FMK
동의어(영문):
CS-2005;CS-1507;Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I
CBNumber:
CB0203438
분자식:
C22H30FN3O7
포뮬러 무게:
467.49
MOL 파일:
Mol file

Z-VAD-FMK 속성

끓는 점
732.4±60.0 °C(Predicted)
밀도
1.214±0.06 g/cm3 (20 ºC 760 Torr)
인화점
396.7℃
저장 조건
-20°C
용해도
DMSO: 20 mg/mL
물리적 상태
powder
산도 계수 (pKa)
11.05±0.46(Predicted)
색상
white
InChIKey
MIFGOLAMNLSLGH-QOKNQOGYSA-N
CAS 데이터베이스
187389-52-2

안전

안전지침서 22-24/25
WGK 독일 3
HS 번호 29145090

Z-VAD-FMK C화학적 특성, 용도, 생산

용도

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

용도

Z-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.

일반 설명

A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.

생물학적 활성

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Biochem/physiol Actions

Cell permeable: yes

효소 저해제

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

Z-VAD-FMK 준비 용품 및 원자재

원자재

준비 용품


Z-VAD-FMK 공급 업체

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