Mecamylamine hydrochloride
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Mecamylamine hydrochloride 속성
- 녹는점
- >240°C (dec.)
- 저장 조건
- 2-8°C
- 용해도
- 에탄올: 122mg/mL
- 산도 계수 (pKa)
- pKa 11.2(H2O,t undefined,I=0.1) (Uncertain)
- 물리적 상태
- Solid
- 색상
- White to off-white
- 수용성
- H2O: 100mM
- 안정성
- 흡습성
- 주요 응용
- 의약품(소분자)
- InChI
- InChI=1/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11;/s3
- InChIKey
- PKVZBNCYEICAQP-YENZGJFJNA-N
- SMILES
- C1(C)(NC)C(C)(C)[C@]2([H])CC[C@@]1([H])C2.Cl |&1:7,11,r|
- CAS 데이터베이스
- 826-39-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 36/37/39 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | RB6900000 | ||
| 위험 등급 | 6.1 | ||
| HS 번호 | 2921300000 | ||
| 스토리지 클래스 | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 3 Oral |
Mecamylamine hydrochloride C화학적 특성, 용도, 생산
개요
Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM), previously used to treat hypertension.Displays antidepressant-like effects in mice.Mecamylamine HCl is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCl. Inactive ingredients are calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, cornstarch, and talc.
화학적 성질
Mecamylamine hydrochloride is a white, odorless, or practically odorless, crystalline powder, is highly stable, soluble in water and has a molecular weight of 203.75.용도
Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input. It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons and in MLO-Y4 cells.용도
Currently, mecamylamine is the only ganglioblocker used for general hypertension; however, the need has declined because of the possibility of addiction and the introduction of many other antihypertensive drugs into medical practice.일반 설명
The secondary aminemecamylamine hydrochloride, N,2,3,3-tetramethyl-2-norbornanaminehydrochloride (Inversine), has a powerful ganglionicblocking effect that is almost identical to that ofhexamethonium. It has an advantage over most of the ganglionicblocking agents in being absorbed readily andsmoothly from the GI tract. It is rarely used, however, forthe treatment of moderate-to-severe hypertension becausesevere orthostatic hypotension occurs when the drug blockssympathetic ganglia.생물학적 활성
Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.Synthesis
Mecamylamine, N,2,3,3-tetramethylnorbornan-2-ylamine (14.2.2), is synthesized from 2,3,3-trimethylnorbornen-2, which is reacted in a Ritter reaction conditions with hydrogen cyanide in concentrated sulfuric acid, giving 2,3,3-trimethylnorbornan-2-ylformylamine (14.2.1), the reduction of which by lithium aluminum hydride leads to mecamylamine (14.2.2) [32,33].
신진 대사
Mecamylamine hydrochloride (Inversine) is a secondary amine and can therefore easily penetrate cell membranes. Its absorption from the gastrointestinal tract is more complete than that of the quaternary ammonium compounds. Mecamylamine is well absorbed orally and crosses both the blood-brain and placental barriers; its distribution is not confined to the extracellular space. High concentrations of the drug accumulate in the liver and kidney, and it is excreted unchanged by the kidney. In contrast to most of the highly ionized ganglionic blocking agents, mecamylamine can produce central nervous system effects, including tremors, mental confusion, seizures, mania, and depression.The mechanism by which these central effects are produced is unclear.Mecamylamine is rarely used today as an antihypertensive drug because it blocks both parasympathetic and sympathetic ganglia.Mecamylamine hydrochloride 준비 용품 및 원자재
원자재
준비 용품
Mecamylamine hydrochloride 공급 업체
글로벌( 180)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 |
3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 |
shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 |
1791901229@qq.com | China | 6722 | 52 |
| Aemon Chemical | 0086-755-86198205 |
acinfo@aemonchem.com | China | 1928 | 57 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 9920 | 65 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 |
anhua.mao@aladdin-e.com | China | 29975 | 65 |
| The future of Shanghai Industrial Co., Ltd. | 021-61552785 |
sales@shshiji.com | China | 9531 | 55 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 |
sales@sunlidabio.com | China | 3223 | 55 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 |
2880152141@qq.com | China | 1840 | 55 |