ChemicalBook >제품 카탈로그 >제약 중간체>벌크 의약품 중간체>룩소리티닙

룩소리티닙

룩소리티닙 구조식 이미지

카스 번호:: 941678-49-5

한글명:: 룩소리티닙

동의어(한글):: 룩소리티닙

상품명:: Ruxolitinib

동의어(영문):: Jakafi;Roxolitinib;(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(R)-Ruxolitinib;CS-163;Pridazole;Russolinib;Benzalolin;Ruxolitinib;Ruxolitinib, >=98%

CBNumber:: CB02499581

분자식:: C17H18N6

포뮬러 무게:: 306.37

MOL 파일:: 941678-49-5.mol

속성

안전

용도

공급 업체 370

룩소리티닙 속성

녹는점: 84-89°C

밀도: 1.40

저장 조건: -20°

용해도: DMSO(최대 28mg/ml) 또는 에탄올(가온 시 최대 15mg/ml)에 용해됩니다.

물리적 상태: 백색 분말.

산도 계수 (pKa): 11.63±0.50(Predicted)

색상: 하얀색

안정성: 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

InChI: InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s3

InChIKey: HFNKQEVNSGCOJV-UJHUVDBMNA-N

SMILES: [C@@H](C1CCCC1)(N1N=CC(C2N=CN=C3NC=CC=23)=C1)CC#N |&1:0,r|

CAS 데이터베이스: 941678-49-5

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	29335990
유해 물질 데이터	941678-49-5(Hazardous Substances Data)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P202	모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.

NFPA 704

	0
3		0

룩소리티닙 C화학적 특성, 용도, 생산

개요

In November 2011, the U.S. FDA approved ruxolitinib (INCB018424) for the treatment of patients with intermediate or high-risk myelofibrosis. Ruxolitinib is an ATP-competitive inhibitor of JAK1 and JAK2 (IC_50's of 3.3±1.2 nM and 2.8±1.2 nM, respectively) and inhibition occurs regardless of the JAK2V617F mutational status. Ruxolitinib is a moderately potent inhibitor of the related JAK, TYK2 (IC₅₀=19±3.2 nM) but is selective versus JAK3 (IC₅₀=428±243 nM). It was also selective versus a panel of 26 other kinases at concentrations approximately 100-fold the IC₅₀ of JAK1 and JAK2. Inhibition of JAK1 and JAK2 downregulates the JAK-signal transducer and activator of transcription (STAT) pathway, inhibiting myeloproliferation, inducing apoptosis, and reducing numerous cytokine plasma levels.

용도

Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.

Indications

The JAK family includes four isoforms, JAK1, JAK2, JAK3, and tyrosine kinase (TYK2). Ruxolitinib (Jakafi(R), Incyte Corp.) was the first approved JAK inhibitor, which inhibits both JAK1 and JAK2, used for the treatment of different types of myelofibrosis. Tofacitinib (Xeljanz(R), Pfizer) was approved by FDA as a JAK3-selective inhibitor for the treatment of rheumatoid arthritis and is one of the only two FDA-approved kinase inhibitors for non-oncological indications.

정의

ChEBI: A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, includ ng primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.

룩소리티닙 준비 용품 및 원자재

원자재

준비 용품

룩소리티닙 공급 업체

글로벌( 370)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Zhengzhou Anhuida Chemical Co., Ltd	+8615903659408	admin@ahdchem.com	China	298	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	+86-576-88902229;+86-0576-88902229 +8613968687450	yuxin@yuxchem.com	China	122	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Senova Technology Co. Ltd.	+86-0755-86703119 +8618503098836	info@senovatech.com	China	349	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Guangzhou Tengyue Chemical Co., Ltd.	+86-86-18148706580 +8618826483838	evan@tyvovo.com	China	152	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7786	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58

룩소리티닙 관련 검색:

DL-말산 Rucaparib 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Posaconazole Calcium dobesilate S-Ruxolitinib (INCB018424) 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Ruxolitinib phosphate Ponatinib Lenalidomide Abiraterone Gefitinib Ibrutinib Bortezomib Y27632 (hydrochloride) MK-2206 2HCl Dasatinib Trametinib